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Diagnostic prediction and clinical reasoning are critical tasks in healthcare applications. While Large Language Models (LLMs) have shown strong capabilities in commonsense reasoning, they still struggle with diagnostic reasoning due to…

Computation and Language · Computer Science 2026-04-28 Yimin Deng , Zhenxi Lin , Yejing Wang , Guoshuai Zhao , Pengyue Jia , Zichuan Fu , Derong Xu , Yefeng Zheng , Xiangyu Zhao , Li Zhu , Xian Wu , Xueming Qian

Upholding data privacy especially in medical research has become tantamount to facing difficulties in accessing individual-level patient data. Estimating mixed effects binary logistic regression models involving data from multiple data…

Methodology · Statistics 2025-10-06 Marie Analiz April Limpoco , Christel Faes , Niel Hens

Adaptive machine learning (ML) aims to allow ML models to adapt to ever-changing environments with potential concept drift after model deployment. Traditionally, adaptive ML requires a new dataset to be manually labeled to tailor deployed…

Machine Learning · Computer Science 2024-04-10 Yutian Ren , Aaron Haohua Yen , G. P. Li

Relevant recommendation is a special recommendation scenario which provides relevant items when users express interests on one target item (e.g., click, like and purchase). Besides considering the relevance between recommendations and…

Information Retrieval · Computer Science 2022-06-13 Zihan Lin , Hui Wang , Jingshu Mao , Wayne Xin Zhao , Cheng Wang , Peng Jiang , Ji-Rong Wen

Computation of Mutual Information (MI) helps understand the amount of information shared between a pair of random variables. Automated feature selection techniques based on MI ranking are regularly used to extract information from sensitive…

Cryptography and Security · Computer Science 2020-09-24 Ankit Srivastava , Samira Pouyanfar , Joshua Allen , Ken Johnston , Qida Ma

In medical domain, data features often contain missing values. This can create serious bias in the predictive modeling. Typical standard data mining methods often produce poor performance measures. In this paper, we propose a new method to…

Machine Learning · Statistics 2015-03-24 Talayeh Razzaghi , Oleg Roderick , Ilya Safro , Nick Marko

We consider high-dimensional regression over subgroups of observations. Our work is motivated by biomedical problems, where disease subtypes, for example, may differ with respect to underlying regression models, but sample sizes at the…

The interpretability of deep learning is crucial for evaluating the reliability of medical imaging models and reducing the risks of inaccurate patient recommendations. This study addresses the "human out of the loop" and "trustworthiness"…

Computer Vision and Pattern Recognition · Computer Science 2024-07-01 Haozhe Luo , Aurélie Pahud de Mortanges , Oana Inel , Abraham Bernstein , Mauricio Reyes

Estimating treatment effects from observational data is of central interest across numerous application domains. Individual treatment effect offers the most granular measure of treatment effect on an individual level, and is the most useful…

Machine Learning · Statistics 2024-08-06 Hengrui Cai , Huaqing Jin , Lexin Li

Multimodal learning leverages complementary information derived from different modalities, thereby enhancing performance in medical image segmentation. However, prevailing multimodal learning methods heavily rely on extensive well-annotated…

Computer Vision and Pattern Recognition · Computer Science 2024-09-05 Xiaogen Zhou , Yiyou Sun , Min Deng , Winnie Chiu Wing Chu , Qi Dou

Item Response Theory (IRT) models are widely used to estimate respondents' latent abilities and calibrate item difficulty. Traditional IRT estimation typically requires centralizing all raw responses, raising privacy and governance…

Machine Learning · Computer Science 2026-04-07 Biying Zhou , Nanyu Luo , Feng Ji

Multimodal data modeling has emerged as a powerful approach in clinical research, enabling the integration of diverse data types such as imaging, genomics, wearable sensors, and electronic health records. Despite its potential to improve…

Modern high-throughput biomedical devices routinely produce data on a large scale, and the analysis of high-dimensional datasets has become commonplace in biomedical studies. However, given thousands or tens of thousands of measured…

Methodology · Statistics 2022-02-28 Vladimir Vutov , Thorsten Dickhaus

A novel functional additive model is proposed which is uniquely modified and constrained to model nonlinear interactions between a treatment indicator and a potentially large number of functional and/or scalar pretreatment covariates. The…

Methodology · Statistics 2021-01-26 Hyung Park , Eva Petkova , Thaddeus Tarpey , R. Todd Ogden

Alignment evaluation in machine learning has largely become evaluation of models. Influential benchmarks score model outputs under fixed inputs, such as truthfulness, instruction following, or pairwise preference, and these scores are often…

Artificial Intelligence · Computer Science 2026-05-07 Varad Vishwarupe , Nigel Shadbolt , Marina Jirotka , Ivan Flechais

Recent technological developments have enabled us to collect complex and high-dimensional data in many scientific fields, such as population health, meteorology, econometrics, geology, and psychology. It is common to encounter such datasets…

Methodology · Statistics 2020-03-16 Ufuk Beyaztas , Han Lin Shang

Purpose: Federated training is often hindered by heterogeneous datasets due to divergent data storage options, inconsistent naming schemes, varied annotation procedures, and disparities in label quality. This is particularly evident in the…

Content-based medical image retrieval is an important diagnostic tool that improves the explainability of computer-aided diagnosis systems and provides decision making support to healthcare professionals. Medical imaging data, such as…

Computer Vision and Pattern Recognition · Computer Science 2022-11-23 Yunyan Xing , Benjamin J. Meyer , Mehrtash Harandi , Tom Drummond , Zongyuan Ge

We investigate performance disparities in deep classifiers. We find that the ability of classifiers to separate individuals into subgroups varies substantially across medical imaging modalities and protected characteristics; crucially, we…

Computer Vision and Pattern Recognition · Computer Science 2023-07-07 Charles Jones , Mélanie Roschewitz , Ben Glocker

Differential diagnosis of mental disorders remains a fundamental challenge in real-world clinical practice, where multiple conditions often exhibit overlapping symptoms. However, most existing public datasets are developed under…