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Large Language Models (LLMs) have shown impressive performance on existing medical question-answering benchmarks. This high performance makes it increasingly difficult to meaningfully evaluate and differentiate advanced methods. We present…

Computation and Language · Computer Science 2025-03-21 Xiangru Tang , Daniel Shao , Jiwoong Sohn , Jiapeng Chen , Jiayi Zhang , Jinyu Xiang , Fang Wu , Yilun Zhao , Chenglin Wu , Wenqi Shi , Arman Cohan , Mark Gerstein

The rapid progress of Large Language Models (LLMs) has given rise to a new category of autonomous AI systems, referred to as Deep Research (DR) agents. These agents are designed to tackle complex, multi-turn informational research tasks by…

Artificial Intelligence · Computer Science 2025-09-04 Yuxuan Huang , Yihang Chen , Haozheng Zhang , Kang Li , Huichi Zhou , Meng Fang , Linyi Yang , Xiaoguang Li , Lifeng Shang , Songcen Xu , Jianye Hao , Kun Shao , Jun Wang

Designing de novo proteins beyond those found in nature holds significant promise for advancements in both scientific and engineering applications. Current methodologies for protein design often rely on AI-based models, such as surrogate…

Soft Condensed Matter · Physics 2024-02-08 A. Ghafarollahi , M. J. Buehler

The era of intelligent agents is upon us, driven by revolutionary advancements in large language models. Large Language Model (LLM) agents, with goal-driven behaviors and dynamic adaptation capabilities, potentially represent a critical…

Large language models (LLMs) and LLM-based agents are increasingly deployed as assistants in planning and decision making, yet most existing systems are implicitly optimized for a single-principal interaction paradigm, in which the model is…

Computation and Language · Computer Science 2026-04-29 Shu Yang , Shenzhe Zhu , Hao Zhu , José Ramón Enríquez , Di Wang , Alex Pentland , Michiel A. Bakker , Jiaxin Pei

Modern Large Language Models (LLMs) exhibit impressive zero-shot and few-shot generalization capabilities across complex natural language tasks, enabling their widespread use as virtual assistants for diverse applications such as…

Computation and Language · Computer Science 2025-06-19 Arjun Vaithilingam Sudhakar

Large Language Models (LLMs) can elicit unintended and even harmful content when misaligned with human values, posing severe risks to users and society. To mitigate these risks, current evaluation benchmarks predominantly employ…

Artificial Intelligence · Computer Science 2024-11-08 Jingnan Zheng , Han Wang , An Zhang , Tai D. Nguyen , Jun Sun , Tat-Seng Chua

The pace of scientific research, vital for improving human life, is complex, slow, and needs specialized expertise. Meanwhile, novel, impactful research often stems from both a deep understanding of prior work, and a cross-pollination of…

Computation and Language · Computer Science 2025-02-11 Jinheon Baek , Sujay Kumar Jauhar , Silviu Cucerzan , Sung Ju Hwang

Large language models (LLMs) have demonstrated strong reasoning, planning, and communication abilities, enabling them to operate as autonomous agents in open environments. While single-agent systems remain limited in adaptability and…

Multiagent Systems · Computer Science 2026-01-22 Jianing Hao , Han Ding , Yuanjian Xu , Tianze Sun , Ran Chen , Wanbo Zhang , Guang Zhang , Siguang Li

Multi-agent systems built on large language models have shown strong performance on complex reasoning tasks, yet most work focuses on agent roles and orchestration while treating inter-agent communication as a fixed interface. Latent…

Artificial Intelligence · Computer Science 2026-04-24 Ye Yu , Heming Liu , Haibo Jin , Xiaopeng Yuan , Peng Kuang , Haohan Wang

Mental disorders represent a critical global health challenge, and social media is increasingly viewed as a vital resource for real-time digital phenotyping and intervention. To leverage this data, large language models (LLMs) have been…

Computation and Language · Computer Science 2025-12-23 Zhuohan Ge , Darian Li , Yubo Wang , Nicole Hu , Xinyi Zhu , Haoyang Li , Xin Zhang , Mingtao Zhang , Shihao Qi , Yuming Xu , Han Shi , Chen Jason Zhang , Qing Li

When automating plan generation for a real-world sequential decision problem, the goal is often not to replace the human planner, but to facilitate an iterative reasoning and elicitation process, where the human's role is to guide the AI…

Artificial Intelligence · Computer Science 2026-04-10 Guilhem Fouilhé , Rebecca Eifler , Antonin Poché , Sylvie Thiébaux , Nicholas Asher

Drug-drug interaction event (DDIE) prediction is crucial for preventing adverse reactions and ensuring optimal therapeutic outcomes. However, existing methods often face challenges with imbalanced datasets, complex interaction mechanisms,…

Machine Learning · Computer Science 2026-03-16 Pengfei Liu , Jun Tao , Zhixiang Ren

Enhancing fuel efficiency in public transportation requires the integration of complex multimodal data into interpretable, decision-relevant insights. However, traditional analytics and visualization methods often yield fragmented outputs…

Artificial Intelligence · Computer Science 2025-11-18 Zhipeng Ma , Ali Rida Bahja , Andreas Burgdorf , André Pomp , Tobias Meisen , Bo Nørregaard Jørgensen , Zheng Grace Ma

The pursuit of human-level artificial intelligence (AI) has significantly advanced the development of autonomous agents and Large Language Models (LLMs). LLMs are now widely utilized as decision-making agents for their ability to interpret…

Human social interactions depend on the ability to infer others' unspoken intentions, emotions, and beliefs-a cognitive skill grounded in the psychological concept of Theory of Mind (ToM). While large language models (LLMs) excel in…

Computation and Language · Computer Science 2025-10-15 Xuanming Zhang , Yuxuan Chen , Samuel Yeh , Sharon Li

Large Language Models (LLMs) have become a popular interface for human-AI interaction, supporting information seeking and task assistance through natural, multi-turn dialogue. To respond to users within multi-turn dialogues, the…

Computation and Language · Computer Science 2026-04-16 Fengran Mo , Yifan Gao , Sha Li , Hansi Zeng , Xin Liu , Zhaoxuan Tan , Xian Li , Jianshu Chen , Dakuo Wang , Meng Jiang

Large Language Models (LLMs) have enabled multi-agent systems to perform autonomous code generation for complex tasks. Despite the recent growth in research and industrial applications in this area, there is little work on synthesizing…

Software Engineering · Computer Science 2026-04-21 Zeeshan Rasheeda , Muhammad Waseema , Kai-Kristian Kemella , Mika Saari , Pekka Abrahamsson

Modern large language models (LLMs) like ChatGPT have shown remarkable performance on general language tasks but still struggle on complex reasoning tasks, which drives the research on cognitive behaviors of LLMs to explore human-like…

Computation and Language · Computer Science 2024-10-10 Tian Liang , Zhiwei He , Wenxiang Jiao , Xing Wang , Yan Wang , Rui Wang , Yujiu Yang , Shuming Shi , Zhaopeng Tu

The intricate nature of modern surgical care necessitates intelligent systems that can synthesize extensive patient records, support collaborative decision-making, and provide transparent, auditable reasoning across the entire perioperative…

Computation and Language · Computer Science 2026-05-29 Dongsheng Shi , Yue Li , Xin Yi , Yongyi Cui , Huawei Feng , Linlin Wang