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Annotating cancerous regions in whole-slide images (WSIs) of pathology samples plays a critical role in clinical diagnosis, biomedical research, and machine learning algorithms development. However, generating exhaustive and accurate…

Computer Vision and Pattern Recognition · Computer Science 2022-06-09 Zhenzhen Wang , Carla Saoud , Sintawat Wangsiricharoen , Aaron W. James , Aleksander S. Popel , Jeremias Sulam

Whole Slide Image (WSI) classification has very significant applications in clinical pathology, e.g., tumor identification and cancer diagnosis. Currently, most research attention is focused on Multiple Instance Learning (MIL) using static…

Computer Vision and Pattern Recognition · Computer Science 2025-04-17 Jiaxiang Gou , Luping Ji , Pei Liu , Mao Ye

Label noise in multi-label learning (MLL) poses significant challenges for model training, particularly in partial multi-label learning (PML) where candidate labels contain both relevant and irrelevant labels. While clustering offers a…

Machine Learning · Computer Science 2026-04-13 Yu Chen , Weijun Lv , Yue Huang , Xuhuan Zhu , Fang Li

Instance segmentation is a fundamental research in computer vision, especially in autonomous driving. However, manual mask annotation for instance segmentation is quite time-consuming and costly. To address this problem, some prior works…

Computer Vision and Pattern Recognition · Computer Science 2023-12-19 Guangfeng Jiang , Jun Liu , Yuzhi Wu , Wenlong Liao , Tao He , Pai Peng

In digital pathology, Whole Slide Image (WSI) analysis is usually formulated as a Multiple Instance Learning (MIL) problem. Although transformer-based architectures have been used for WSI classification, these methods require modifications…

Computer Vision and Pattern Recognition · Computer Science 2023-10-03 Juan I. Pisula , Katarzyna Bozek

Weakly supervised learning aims at coping with scarce labeled data. Previous weakly supervised studies typically assume that there is only one kind of weak supervision in data. In many applications, however, raw data usually contains more…

Machine Learning · Computer Science 2020-01-27 Lan-Zhe Guo , Feng Kuang , Zhang-Xun Liu , Yu-Feng Li , Nan Ma , Xiao-Hu Qie

Lifelong learning on Whole Slide Images (WSIs) aims to train or fine-tune a unified model sequentially on cancer-related tasks, reducing the resources and effort required for data transfer and processing, especially given the gigabyte-scale…

Computer Vision and Pattern Recognition · Computer Science 2025-11-18 Doanh C. Bui , Ba Hung Ngo , Hoai Luan Pham , Khang Nguyen , Maï K. Nguyen , Yasuhiko Nakashima

In this paper, we investigate the challenges of complementary-label learning (CLL), a specialized form of weakly-supervised learning (WSL) where models are trained with labels indicating classes to which instances do not belong, rather than…

Machine Learning · Computer Science 2026-02-03 Tan-Ha Mai , Hsuan-Tien Lin

Semi-Supervised Learning (SSL) can leverage abundant unlabeled data to boost model performance. However, the class-imbalanced data distribution in real-world scenarios poses great challenges to SSL, resulting in performance degradation.…

Computer Vision and Pattern Recognition · Computer Science 2025-01-13 Yin Wang , Zixuan Wang , Hao Lu , Zhen Qin , Hailiang Zhao , Guanjie Cheng , Ge Su , Li Kuang , Mengchu Zhou , Shuiguang Deng

Multiple instance learning (MIL) significantly reduced annotation costs via bag-level weak labels for large-scale images, such as histopathological whole slide images (WSIs). However, its adaptability to continual tasks with minimal…

Computer Vision and Pattern Recognition · Computer Science 2025-07-09 Byung Hyun Lee , Wongi Jeong , Woojae Han , Kyoungbun Lee , Se Young Chun

Digital pathology based on whole slide images (WSIs) plays a key role in cancer diagnosis and clinical practice. Due to the high resolution of the WSI and the unavailability of patch-level annotations, WSI classification is usually…

Computer Vision and Pattern Recognition · Computer Science 2023-05-02 Litao Yang , Deval Mehta , Sidong Liu , Dwarikanath Mahapatra , Antonio Di Ieva , Zongyuan Ge

In the application of Multiple Instance Learning (MIL) methods for Whole Slide Image (WSI) classification, attention mechanisms often focus on a subset of discriminative instances, which are closely linked to overfitting. To mitigate…

Computer Vision and Pattern Recognition · Computer Science 2024-07-08 Yunlong Zhang , Honglin Li , Yuxuan Sun , Sunyi Zheng , Chenglu Zhu , Lin Yang

The field of Weakly Supervised Learning (WSL) has recently seen a surge of popularity, with numerous papers addressing different types of "supervision deficiencies", namely: poor quality, non adaptability, and insufficient quantity of…

Machine Learning · Computer Science 2021-09-28 Pierre Nodet , Vincent Lemaire , Alexis Bondu , Antoine Cornuéjols

We consider machine-learning-based thyroid-malignancy prediction from cytopathology whole-slide images (WSI). Multiple instance learning (MIL) approaches, typically used for the analysis of WSIs, divide the image (bag) into patches…

Multiple instance learning (MIL) is a key algorithm for classification of whole slide images (WSI). Histology WSIs can have billions of pixels, which create enormous computational and annotation challenges. Typically, such images are…

Image and Video Processing · Electrical Eng. & Systems 2021-11-03 Andriy Myronenko , Ziyue Xu , Dong Yang , Holger Roth , Daguang Xu

Weak supervision (WS) is a rich set of techniques that produce pseudolabels by aggregating easily obtained but potentially noisy label estimates from a variety of sources. WS is theoretically well understood for binary classification, where…

Machine Learning · Computer Science 2022-11-28 Harit Vishwakarma , Nicholas Roberts , Frederic Sala

Multiple Instance Learning (MIL) has been widely applied in histopathology to classify Whole Slide Images (WSIs) with slide-level diagnoses. While the ground truth is established by expert pathologists, the slides can be difficult to…

Computer Vision and Pattern Recognition · Computer Science 2026-03-11 Marie Arrivat , Rémy Peyret , Elsa Angelini , Pietro Gori

Multiple instance learning (MIL) has been widely used for representing whole-slide pathology images. However, spatial, semantic, and decision entanglements among instances limit its representation and interpretability. To address these…

Computer Vision and Pattern Recognition · Computer Science 2025-11-05 Chentao Li , Behzad Bozorgtabar , Yifang Ping , Pan Huang , Jing Qin

Whole-slide images (WSIs) are critical for cancer diagnosis due to their ultra-high resolution and rich semantic content. However, their massive size and the limited availability of fine-grained annotations pose substantial challenges for…

Computer Vision and Pattern Recognition · Computer Science 2025-06-30 Daoxi Cao , Hangbei Cheng , Yijin Li , Ruolin Zhou , Xuehan Zhang , Xinyi Li , Binwei Li , Xuancheng Gu , Jianan Zhang , Xueyu Liu , Yongfei Wu

As advanced image manipulation techniques emerge, detecting the manipulation becomes increasingly important. Despite the success of recent learning-based approaches for image manipulation detection, they typically require expensive…

Computer Vision and Pattern Recognition · Computer Science 2023-09-06 Yuanhao Zhai , Tianyu Luan , David Doermann , Junsong Yuan
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