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We present a time dependent variational method to learn the mechanisms of equilibrium reactive processes and efficiently evaluate their rates within a transition path ensemble. This approach builds off variational path sampling methodology…

Chemical Physics · Physics 2023-07-10 Aditya N. Singh , David T. Limmer

In this paper, we study weakly dynamic undirected graphs, that can be used to represent some logistic networks. The goal is to deliver all the delivery points in the network. The network exists in a mostly stable environment, except for a…

Data Structures and Algorithms · Computer Science 2019-04-11 Moustafa Nakechbandi , Jean-Yves Colin , Hervé Mathieu

Global dynamics in nonlinear stochastic systems is often difficult to analyze rigorously. Yet, many excellent numerical methods exist to approximate these systems. In this work, we propose a method to bridge the gap between computation and…

Dynamical Systems · Mathematics 2019-01-07 Maxime Breden , Christian Kuehn

In this work, we seek to simulate rare transitions between metastable states using score-based generative models. An efficient method for generating high-quality transition paths is valuable for the study of molecular systems since data is…

Computational Physics · Physics 2023-09-20 Luke Triplett , Jianfeng Lu

We propose two novel techniques --- stacking bottleneck features and minimum generation error training criterion --- to improve the performance of deep neural network (DNN)-based speech synthesis. The techniques address the related issues…

Sound · Computer Science 2016-11-17 Zhizheng Wu , Simon King

Simulating transition dynamics between metastable states is a fundamental challenge in dynamical systems and stochastic processes with wide real-world applications in understanding protein folding, chemical reactions and neural activities.…

Machine Learning · Computer Science 2024-10-22 Haibo Wang , Yuxuan Qiu , Yanze Wang , Rob Brekelmans , Yuanqi Du

We describe a robust and efficient chain-of-states method for computing Minimum Energy Paths~(MEPs) associated to barrier-crossing events in poly-atomic systems. The path is parametrized in terms of a continuous variable $t \in [0,1]$ that…

Chemical Physics · Physics 2015-10-26 E. R. Hernandez , C. P. Herrero , J. M. Soler

In this paper, we present a novel learning framework for finding shortest paths in graphs utilizing Generative Flow Networks (GFlowNets). First, we examine theoretical properties of GFlowNets in non-acyclic environments in relation to…

Machine Learning · Computer Science 2026-03-03 Nikita Morozov , Ian Maksimov , Daniil Tiapkin , Sergey Samsonov

Many chemical reactions can be formulated in terms of particle diffusion in a complex energy landscape. Transition path theory (TPT) is a theoretical framework for describing the direct (reaction) pathways from reactant to product states…

Statistical Mechanics · Physics 2023-10-03 Paul C Bressloff

We present a novel optimization strategy for training neural networks which we call "BitNet". The parameters of neural networks are usually unconstrained and have a dynamic range dispersed over all real values. Our key idea is to limit the…

Machine Learning · Computer Science 2018-11-20 Aswin Raghavan , Mohamed Amer , Sek Chai , Graham Taylor

Binary neural networks (BNNs) have been widely adopted to reduce the computational cost and memory storage on edge-computing devices by using one-bit representation for activations and weights. However, as neural networks become…

Computer Vision and Pattern Recognition · Computer Science 2023-08-29 Quang Hieu Vo , Linh-Tam Tran , Sung-Ho Bae , Lok-Won Kim , Choong Seon Hong

We present SplineNets, a practical and novel approach for using conditioning in convolutional neural networks (CNNs). SplineNets are continuous generalizations of neural decision graphs, and they can dramatically reduce runtime complexity…

Machine Learning · Computer Science 2018-11-01 Cem Keskin , Shahram Izadi

Flow matching trains a neural velocity field by regression against a target velocity associated with a prescribed probability path connecting a simple initial distribution to the data distribution. A central design choice is the path…

Machine Learning · Computer Science 2026-05-21 Shukai Du , Junzhe Zhang , Yiming Li

Understanding the dynamics of complex molecular processes is often linked to the study of infrequent transitions between long-lived stable states. The standard approach to the sampling of such rare events is to generate an ensemble of…

Computational Physics · Physics 2023-05-22 Sebastian Falkner , Alessandro Coretti , Salvatore Romano , Phillip Geissler , Christoph Dellago

The emergence of transition phenomena between metastable states induced by noise plays a fundamental role in a broad range of nonlinear systems. The computation of the most probable paths is a key issue to understand the mechanism of…

Dynamical Systems · Mathematics 2021-01-27 Yang Li , Jinqiao Duan , Xianbin Liu

The minimum energy path (MEP) describes the mechanism of reaction, and the energy barrier along the path can be used to calculate the reaction rate in thermal systems. The nudged elastic band (NEB) method is one of the most commonly used…

Numerical Analysis · Mathematics 2025-03-24 Xuanyu Liu , Huajie Chen , Christoph Ortner

The probability of trajectories of weakly diffusive processes to remain in the tubular neighbourhood of a smooth path is given by the Freidlin-Wentzell-Graham theory of large deviations. The most probable path between two states (the…

Statistical Mechanics · Physics 2020-08-12 Lukas Kikuchi , Rajesh Singh , Mike E. Cates , Ronojoy Adhikari

The modern theory of rare events is grounded in near equilibrium ideas, however many systems of modern interest are sufficiently far from equilibrium that traditional approaches do not apply. Using the recently developed variational path…

Chemical Physics · Physics 2025-02-14 Aditya N. Singh , David T. Limmer

Rare transitions in stochastic processes can often be rigorously described via an underlying large deviation principle. Recent breakthroughs in the classification of reversible stochastic processes as gradient flows have led to a connection…

Statistical Mechanics · Physics 2019-05-22 Tobias Grafke

The multi-modality and stochastic characteristics of human behavior make motion prediction a highly challenging task, which is critical for autonomous driving. While deep learning approaches have demonstrated their great potential in this…

Computer Vision and Pattern Recognition · Computer Science 2024-03-04 Xiaqiang Tang , Weigao Sun , Siyuan Hu , Yiyang Sun , Yafeng Guo