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Understanding biological processes, drug development, and biotechnological advancements requires a detailed analysis of protein structures and functions, a task that is inherently complex and time-consuming in traditional protein research.…

Artificial Intelligence · Computer Science 2025-04-21 Yijia Xiao , Edward Sun , Yiqiao Jin , Qifan Wang , Wei Wang

Large Language Models (LLMs) with strong abilities in natural language processing tasks have emerged and have been applied in various kinds of areas such as science, finance and software engineering. However, the capability of LLMs to…

Computation and Language · Computer Science 2023-12-29 Taicheng Guo , Kehan Guo , Bozhao Nan , Zhenwen Liang , Zhichun Guo , Nitesh V. Chawla , Olaf Wiest , Xiangliang Zhang

In the field of materials science, comprehending material properties is often hindered by the complexity of datasets originating from various sources. This study introduces the Automated Model Training (AMT) Graphical User Interface (GUI),…

Materials Science · Physics 2024-08-06 Mohamed Bilal Shakeel , Samir Brahim Belhaouari , Fedwa El Mellouhi

In our study, we evaluated large language model (LLM) performance on pharmacy licensure-style question-answering tasks and developed an external knowledge integration method to improve accuracy. We benchmarked ten LLMs with varying…

Traditional biomedical artificial intelligence (AI) models, designed for specific tasks or modalities, often exhibit limited flexibility in real-world deployment and struggle to utilize holistic information. Generalist AI holds the…

While inorganic retrosynthesis planning is essential in the field of chemical science, the application of machine learning in this area has been notably less explored compared to organic retrosynthesis planning. In this paper, we propose…

Machine Learning · Computer Science 2025-10-14 Heewoong Noh , Namkyeong Lee , Gyoung S. Na , Chanyoung Park

Artificial Intelligence (AI) has the potential to fundamentally change the educational landscape. So far, much of the physics education research relating to AI has focused on lecture-based assessment and the ability of ChatGPT to answer…

Physics Education · Physics 2024-01-02 Andrew Low , Z. Yasemin Kalender

Organic synthesis stands as a cornerstone of the chemical industry. The development of robust machine learning models to support tasks associated with organic reactions is of significant interest. However, current methods rely on…

Machine Learning · Computer Science 2025-01-06 Kaipeng Zeng , Xianbin Liu , Yu Zhang , Xiaokang Yang , Yaohui Jin , Yanyan Xu

Natural language processing models have emerged that can generate usable software and automate a number of programming tasks with high fidelity. These tools have yet to have an impact on the chemistry community. Yet, our initial testing…

Statistical Mechanics · Physics 2023-01-11 Glen M. Hocky , Andrew D. White

The pre-trained foundation models (PFMs) have become essential for facilitating large-scale multimodal learning. Researchers have effectively employed the ``pre-train, prompt, and predict'' paradigm through prompt learning to induce…

Computation and Language · Computer Science 2025-12-24 Xiang Chen , Yixin Ou , Quan Feng , Lei Li , Piji Li , Haibo Ye , Sheng-Jun Huang , Shuofei Qiao , Shumin Deng , Huajun Chen , Ningyu Zhang

Materials synthesis is vital for innovations such as energy storage, catalysis, electronics, and biomedical devices. Yet, the process relies heavily on empirical, trial-and-error methods guided by expert intuition. Our work aims to support…

The reverse engineering of a complex mixture, regardless of its nature, has become significant today. Being able to quickly assess the potential toxicity of new commercial products in relation to the environment presents a genuine…

Artificial Intelligence · Computer Science 2023-11-01 Pedro Marote , Marie Martin , Anne Bonhomme , Pierre Lantéri , Yohann Clément

Large Language Models (LLMs) have revo lutionized natural language processing Natural Language Processing (NLP), with Chat Generative Pre-trained Transformer (ChatGPT) standing out as a notable exampledue to its advanced capabilities and…

Computation and Language · Computer Science 2025-03-25 Azim Akhtarshenas , Afshin Dini , Navid Ayoobi

To fully expedite AI-powered chemical research, high-quality chemical databases are the foundation. Automatic extraction of chemical information from the literature is essential for constructing reaction databases, but it is currently…

Artificial Intelligence · Computer Science 2026-03-09 Yufan Chen , Ching Ting Leung , Bowen Yu , Jianwei Sun , Yong Huang , Linyan Li , Hao Chen , Hanyu Gao

Recent advances in generative AI have accelerated the discovery of novel chemicals and materials. However, scaling these discoveries to industrial production remains a major bottleneck due to the synthesis gap -- the need to develop…

Machine Learning · Computer Science 2025-08-19 Sakhinana Sagar Srinivas , Shivam Gupta , Venkataramana Runkana

We present a new framework integrating the AI model GPT-4 into the iterative process of reticular chemistry experimentation, leveraging a cooperative workflow of interaction between AI and a human researcher. This GPT-4 Reticular Chemist is…

Artificial Intelligence · Computer Science 2023-11-01 Zhiling Zheng , Zichao Rong , Nakul Rampal , Christian Borgs , Jennifer T. Chayes , Omar M. Yaghi

The advancement of machine learning and the availability of large-scale reaction datasets have accelerated the development of data-driven models for computer-aided synthesis planning (CASP) in the past decade. Here, we detail the newest…

The growing integration of AI tools in software development, particularly Large Language Models (LLMs) such as ChatGPT, has revolutionized how developers approach coding tasks. However, achieving high-quality code often requires iterative…

Software Engineering · Computer Science 2025-06-03 Sophia DiCuffa , Amanda Zambrana , Priyanshi Yadav , Sashidhar Madiraju , Khushi Suman , Eman Abdullah AlOmar

Machine learning has promised to change the landscape of laboratory chemistry, with impressive results in molecular property prediction and reaction retro-synthesis. However, chemical datasets are often inaccessible to the machine learning…

When considering large sets of molecules, it is helpful to place them in the context of a "chemical space" - a multidimensional space defined by a set of descriptors that can be used to visualize and analyze compound grouping as well as…

Biomolecules · Quantitative Biology 2022-02-01 Monee Y. McGrady , Sean M. Colby , Jamie R Nuñez , Ryan S. Renslow , Thomas O. Metz
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