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Recent studies on deep neural networks show that flat minima of the loss landscape correlate with improved generalization. Sharpness-aware minimization (SAM) efficiently finds flat regions by updating the parameters according to the…

Machine Learning · Computer Science 2025-02-13 Albert Kjøller Jacobsen , Georgios Arvanitidis

The introduction of the Segment Anything Model (SAM) has paved the way for numerous semantic segmentation applications. For several tasks, quantifying the uncertainty of SAM is of particular interest. However, the ambiguous nature of the…

Computer Vision and Pattern Recognition · Computer Science 2025-07-30 Timo Kaiser , Thomas Norrenbrock , Bodo Rosenhahn

It is difficult to accurately label ambiguous and complex shaped targets manually by binary masks. The weakness of binary mask under-expression is highlighted in medical image segmentation, where blurring is prevalent. In the case of…

Computer Vision and Pattern Recognition · Computer Science 2022-01-04 Lin Wang , Lie Ju , Xin Wang , Wanji He , Donghao Zhang , Yelin Huang , Zhiwen Yang , Xuan Yao , Xin Zhao , Xiufen Ye , Zongyuan Ge

When applying a Deep Learning model to medical images, it is crucial to estimate the model uncertainty. Voxel-wise uncertainty is a useful visual marker for human experts and could be used to improve the model's voxel-wise output, such as…

Image and Video Processing · Electrical Eng. & Systems 2022-11-02 Anton Vasiliuk , Daria Frolova , Mikhail Belyaev , Boris Shirokikh

Automatic medical image segmentation is a fundamental step in computer-aided diagnosis, yet fully supervised approaches demand extensive pixel-level annotations that are costly and time-consuming. To alleviate this burden, we propose a…

Computer Vision and Pattern Recognition · Computer Science 2025-10-20 Lei Shi , Gang Li , Junxing Zhang

Medical image segmentation is an important analysis task in clinical practice and research. Deep learning has massively advanced the field, but current approaches are mostly based on models trained for a specific task. Training such models…

Image and Video Processing · Electrical Eng. & Systems 2025-12-18 Anwai Archit , Luca Freckmann , Constantin Pape

Statistical shape modeling (SSM) has recently taken advantage of advances in deep learning to alleviate the need for a time-consuming and expert-driven workflow of anatomy segmentation, shape registration, and the optimization of…

Computer Vision and Pattern Recognition · Computer Science 2020-07-14 Jadie Adams , Riddhish Bhalodia , Shireen Elhabian

Active learning (AL) has found wide applications in medical image segmentation, aiming to alleviate the annotation workload and enhance performance. Conventional uncertainty-based AL methods, such as entropy and Bayesian, often rely on an…

Computer Vision and Pattern Recognition · Computer Science 2024-01-30 Siteng Ma , Haochang Wu , Aonghus Lawlor , Ruihai Dong

Foundation models such as the recently introduced Segment Anything Model (SAM) have achieved remarkable results in image segmentation tasks. However, these models typically require user interaction through handcrafted prompts such as…

Computer Vision and Pattern Recognition · Computer Science 2024-10-01 Mélanie Gaillochet , Christian Desrosiers , Hervé Lombaert

The Segment Anything Model (SAM) is a recently developed large model for general-purpose segmentation for computer vision tasks. SAM was trained using 11 million images with over 1 billion masks and can produce segmentation results for a…

Computer Vision and Pattern Recognition · Computer Science 2023-06-22 Yizhe Zhang , Tao Zhou , Shuo Wang , Peixian Liang , Danny Z. Chen

Uncertainty in medical image segmentation is inherently non-uniform, with boundary regions exhibiting substantially higher ambiguity than interior areas. Conventional training treats all pixels equally, leading to unstable optimization…

Computer Vision and Pattern Recognition · Computer Science 2026-02-25 Jinming Zhang , Youpeng Yang , Xi Yang , Haosen Shi , Yuyao Yan , Qiufeng Wang , Guangliang Cheng , Kaizhu Huang

In clinical applications, the utility of segmentation models is often based on the accuracy of derived downstream metrics such as organ size, rather than by the pixel-level accuracy of the segmentation masks themselves. Thus, uncertainty…

Image and Video Processing · Electrical Eng. & Systems 2026-03-03 Matt Y. Cheung , Ashok Veeraraghavan , Guha Balakrishnan

Large foundation models, known for their strong zero-shot generalization capabilities, can be applied to a wide range of downstream tasks. However, developing foundation models for medical image segmentation poses a significant challenge…

Computer Vision and Pattern Recognition · Computer Science 2025-06-24 Sihan Yang , Jiadong Feng , Xuande Mi , Haixia Bi , Hai Zhang , Jian Sun

Although segmenting natural images has shown impressive performance, these techniques cannot be directly applied to medical image segmentation. Medical image segmentation is particularly complicated by inherent uncertainties. For instance,…

Image and Video Processing · Electrical Eng. & Systems 2024-08-06 Jiayuan Zhu , Junde Wu

Segmentation of medical images constitutes an essential component of medical image analysis, providing the foundation for precise diagnosis and efficient therapeutic interventions in clinical practices. Despite substantial progress, most…

Computer Vision and Pattern Recognition · Computer Science 2025-11-18 Muzammal Shafique , Nasir Rahim , Jamil Ahmad , Mohammad Siadat , Khalid Malik , Ghaus Malik

Accurate brain image segmentation, particularly for distinguishing various tissues from magnetic resonance imaging (MRI) images, plays a pivotal role in finding the neurological dis ease and medical image computing. In deep learning…

Computer Vision and Pattern Recognition · Computer Science 2026-04-21 Hanuman Verma , Akshansh Gupta , Pranabesh Maji , Saurav Mandal , Vijay Kumar Pandey

Deep learning has played a major role in the interpretation of dermoscopic images for detecting skin defects and abnormalities. However, current deep learning solutions for dermatological lesion analysis are typically limited in providing…

Computer Vision and Pattern Recognition · Computer Science 2021-07-20 Gun-Hee Lee , Han-Bin Ko , Seong-Whan Lee

The self-configuring nnU-Net has achieved leading performance in a large range of medical image segmentation challenges. It is widely considered as the model of choice and a strong baseline for medical image segmentation. However, despite…

Computer Vision and Pattern Recognition · Computer Science 2024-05-02 Yidong Zhao , Changchun Yang , Artur Schweidtmann , Qian Tao

Segment Anything Model (SAM), a prompt-driven foundation model for natural image segmentation, has demonstrated impressive zero-shot performance. However, SAM does not work when directly applied to medical image segmentation, since SAM…

Computer Vision and Pattern Recognition · Computer Science 2025-03-25 Bin Xie , Hao Tang , Bin Duan , Dawen Cai , Yan Yan , Gady Agam

The Segment Anything Model (SAM) has achieved remarkable successes in the realm of natural image segmentation, but its deployment in the medical imaging sphere has encountered challenges. Specifically, the model struggles with medical…

Computer Vision and Pattern Recognition · Computer Science 2024-08-02 Shreyank N Gowda , David A. Clifton