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We present a hybrid classical-quantum framework based on the Frank-Wolfe algorithm, Q-FW, for solving quadratic, linearly-constrained, binary optimization problems on quantum annealers (QA). The computational premise of quantum computers…

Computer Vision and Pattern Recognition · Computer Science 2022-03-25 Alp Yurtsever , Tolga Birdal , Vladislav Golyanik

We propose a modified MSA algorithm on quantum annealers with applications in areas of bioinformatics and genetic sequencing. To understand the human genome, researchers compare extensive sets of these genetic sequences -- or their protein…

Quantum Physics · Physics 2024-03-28 Melody Lee

We propose a novel method for reducing the number of variables in quadratic unconstrained binary optimization problems, using a quantum annealer (or any sampler) to fix the value of a large portion of the variables to values that have a…

Quantum Physics · Physics 2017-09-26 Hamed Karimi , Gili Rosenberg

Cancer classification based on gene expression increases early diagnosis and recovery, but high-dimensional genes with a small number of samples are a major challenge. This work introduces a new hybrid quantum kernel support vector machine…

Machine Learning · Computer Science 2022-02-25 Essam H. Houssein , Zainab Abohashima , Mohamed Elhoseny , Waleed M. Mohamed

Quantum kernels hold great promise for offering computational advantages over classical learners, with the effectiveness of these kernels closely tied to the design of the quantum feature map. However, the challenge of designing effective…

Quantum Physics · Physics 2024-01-23 Cong Lei , Yuxuan Du , Peng Mi , Jun Yu , Tongliang Liu

Quadratic unconstrained binary optimization (QUBO) has become the standard format for optimization using quantum computers, i.e., for both the quantum approximate optimization algorithm (QAOA) and quantum annealing (QA). We present a…

Quantum Physics · Physics 2022-04-26 Thomas Gabor , Marian Lingsch Rosenfeld , Sebastian Feld , Claudia Linnhoff-Popien

The recent emergence of novel computational devices, such as quantum computers, coherent Ising machines, and digital annealers presents new opportunities for hardware-accelerated hybrid optimization algorithms. Unfortunately, demonstrations…

Optimization and Control · Mathematics 2020-10-21 Yuchen Pang , Carleton Coffrin , Andrey Y. Lokhov , Marc Vuffray

The presence of a bias field, encoding some information about the target state, can enhance the performance of quantum optimization methods. Here we investigate the effect of such a bias field on the outcome of quantum annealing sampling,…

Quantum Physics · Physics 2022-10-19 Tobias Graß

We assess the prospects for algorithms within the general framework of quantum annealing (QA) to achieve a quantum speedup relative to classical state of the art methods in combinatorial optimization and related sampling tasks. We argue for…

Quantum Physics · Physics 2021-06-22 E. J. Crosson , D. A. Lidar

The Quantum Approximate Optimization Algorithm (QAOA) requires considered optimization problems to be translated into a compatible format. A popular transformation step in this pipeline involves the quadratization of higher-order binary…

Quantum Physics · Physics 2025-11-26 Damian Rovara , Lukas Burgholzer , Robert Wille

In recent years, the advances in single-cell RNA-seq techniques have enabled us to perform large-scale transcriptomic profiling at single-cell resolution in a high-throughput manner. Unsupervised learning such as data clustering has become…

Genomics · Quantitative Biology 2020-01-07 Shixiong Zhang , Xiangtao Li , Qiuzhen Lin , Ka-Chun Wong

Quantum Annealing (QA) is one of the most promising frameworks for quantum optimization. Here, we focus on the problem of minimizing complex classical cost functions associated with prototypical discrete neural networks, specifically the…

Quantum Physics · Physics 2023-05-17 Guglielmo Lami , Pietro Torta , Giuseppe E. Santoro , Mario Collura

Single-cell RNA sequencing (scRNA-seq) has revolutionized our ability to analyze gene expression at the cellular level. By providing data on gene expression for each individual cell, scRNA-seq generates large datasets with thousands of…

Computational Complexity · Computer Science 2025-02-11 Md Romizul Islam , Swakkhar Shatabda

Quantum annealing has great promise in leveraging quantum mechanics to solve combinatorial optimisation problems. However, to realize this promise to it's fullest extent we must appropriately leverage the underlying physics. In this spirit,…

Quantum Physics · Physics 2020-12-10 Nicholas Chancellor

Brief description on the state of the art of some local optimization methods: Quantum annealing Quantum annealing (also known as alloy, crystallization or tempering) is analogous to simulated annealing but in substitution of thermal…

Data Structures and Algorithms · Computer Science 2014-04-10 Alfonso de la Fuente Ruiz

The ability to accurately classify disease subtypes is of vital importance, especially in oncology where this capability could have a life saving impact. Here we report a classification between two subtypes of non-small cell lung cancer,…

Machine Learning · Statistics 2018-10-30 Siddhant Jain , Jalal Ziauddin , Paul Leonchyk , Joseph Geraci

Quantum annealing is a powerful tool for solving and approximating combinatorial optimization problems such as graph partitioning, community detection, centrality, routing problems, and more. In this paper we explore the use of quantum…

Quantum Physics · Physics 2025-07-17 Joel E. Pion , Susan M. Mniszewski

Assessing cyber risk in complex IT infrastructures poses significant challenges due to the dynamic, interconnected nature of digital systems. Traditional methods often fall short, relying on static and largely qualitative models that do not…

Quantum Physics · Physics 2026-04-22 Remo Marini , Riccardo Arpe

Single-cell RNA sequencing (scRNA-seq) provides a high throughput, quantitative and unbiased framework for scientists in many research fields to identify and characterize cell types within heterogeneous cell populations from various…

Quantitative Methods · Quantitative Biology 2022-09-28 Yeganeh Madadi , Aboozar Monavarfeshani , Hao Chen , W. Daniel Stamer , Robert W. Williams , Siamak Yousefi

The quest for real-time dynamic optimization solutions in the process industry represents a formidable computational challenge, particularly within the realm of applications like model-predictive control, where rapid and reliable…

Optimization and Control · Mathematics 2024-04-29 Dennis Michael Nenno , Adrian Caspari