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In this study, we propose HOPER (HOlistic ProtEin Representation), a novel multimodal learning framework designed to enhance protein function prediction (PFP) in low-data settings. The challenge of predicting protein functions is compounded…

Biomolecules · Quantitative Biology 2024-12-18 Serbülent Ünsal , Sinem Özdemir , Bünyamin Kasap , M. Erşan Kalaycı , Kemal Turhan , Tunca Doğan , Aybar C. Acar

Histomorphology is crucial in cancer diagnosis. However, existing whole slide image (WSI) classification methods struggle to effectively incorporate histomorphology information, limiting their ability to capture key pathological features.…

Computer Vision and Pattern Recognition · Computer Science 2025-12-01 Baizhi Wang , Rui Yan , Wenxin Ma , Xu Zhang , Yuhao Wang , Xiaolong Li , Yunjie Gu , Zihang Jiang , S. Kevin Zhou

Ophthalmic images may contain identical-looking pathologies that can cause failure in automated techniques to distinguish different retinal degenerative diseases. Additionally, reliance on large annotated datasets and lack of knowledge…

Image and Video Processing · Electrical Eng. & Systems 2022-08-02 Sharif Amit Kamran , Khondker Fariha Hossain , Alireza Tavakkoli , Stewart Lee Zuckerbrod , Salah A. Baker

Multi-modal learning is a fast growing area in artificial intelligence. It tries to help machines understand complex things by combining information from different sources, like images, text, and audio. By using the strengths of each…

Machine Learning · Computer Science 2025-12-22 Qihang Jin , Enze Ge , Yuhang Xie , Hongying Luo , Junhao Song , Ziqian Bi , Chia Xin Liang , Jibin Guan , Joe Yeong , Xinyuan Song , Junfeng Hao

Class-Incremental Learning (CIL) aims to continually learn new categories without forgetting previously acquired knowledge. Vision-language models such as CLIP offer strong transferable representations via multi-modal supervision, making…

Computer Vision and Pattern Recognition · Computer Science 2025-11-17 Lan Li , Tao Hu , Da-Wei Zhou , Han-Jia Ye , De-Chuan Zhan

Improving the fairness of federated learning (FL) benefits healthy and sustainable collaboration, especially for medical applications. However, existing fair FL methods ignore the specific characteristics of medical FL applications, i.e.,…

Machine Learning · Computer Science 2024-10-29 Yunlu Yan , Lei Zhu , Yuexiang Li , Xinxing Xu , Rick Siow Mong Goh , Yong Liu , Salman Khan , Chun-Mei Feng

Multimodal representation learning has shown promising improvements on various vision-language tasks. Most existing methods excel at building global-level alignment between vision and language while lacking effective fine-grained image-text…

Computer Vision and Pattern Recognition · Computer Science 2023-06-16 Zijia Zhao , Longteng Guo , Xingjian He , Shuai Shao , Zehuan Yuan , Jing Liu

Healthcare applications are inherently multimodal, benefiting greatly from the integration of diverse data sources. However, the modalities available in clinical settings can vary across different locations and patients. A key area that…

Computer Vision and Pattern Recognition · Computer Science 2025-09-04 Mohammed Amer , Mohamed A. Suliman , Tu Bui , Nuria Garcia , Serban Georgescu

Clinicians usually combine information from multiple sources to achieve the most accurate diagnosis, and this has sparked increasing interest in leveraging multimodal deep learning for diagnosis. However, in real clinical scenarios, due to…

Computer Vision and Pattern Recognition · Computer Science 2025-08-05 Kai Han , Chongwen Lyu , Lele Ma , Chengxuan Qian , Siqi Ma , Zheng Pang , Jun Chen , Zhe Liu

Cancer has relational information residing at varying scales, modalities, and resolutions of the acquired data, such as radiology, pathology, genomics, proteomics, and clinical records. Integrating diverse data types can improve the…

Machine Learning · Computer Science 2024-07-29 Asim Waqas , Aakash Tripathi , Ravi P. Ramachandran , Paul Stewart , Ghulam Rasool

Constructing a multi-modal automatic classification model based on three types of renal biopsy images can assist pathologists in glomerular multi-disease identification. However, the substantial scale difference between transmission…

Computer Vision and Pattern Recognition · Computer Science 2025-12-18 Kaixing Long , Danyi Weng , Yun Mi , Zhentai Zhang , Yanmeng Lu , Jian Geng , Zhitao Zhou , Liming Zhong , Qianjin Feng , Wei Yang , Lei Cao

Histopathological imaging is vital for cancer research and clinical practice, with multiplexed Immunofluorescence (MxIF) and Hematoxylin and Eosin (H&E) providing complementary insights. However, aligning different stains at the cell level…

Image and Video Processing · Electrical Eng. & Systems 2024-10-02 Jun Jiang , Raymond Moore , Brenna Novotny , Leo Liu , Zachary Fogarty , Ray Guo , Markovic Svetomir , Chen Wang

Decoding neural visual representations from electroencephalogram (EEG)-based brain activity is crucial for advancing brain-machine interfaces (BMI) and has transformative potential for neural sensory rehabilitation. While multimodal…

Computer Vision and Pattern Recognition · Computer Science 2025-03-25 Yueyang Li , Zijian Kang , Shengyu Gong , Wenhao Dong , Weiming Zeng , Hongjie Yan , Wai Ting Siok , Nizhuan Wang

Cytology slides are essential tools in diagnosing and staging cancer, but their analysis is time-consuming and costly. Foundation models have shown great potential to assist in these tasks. In this paper, we explore how existing foundation…

Image and Video Processing · Electrical Eng. & Systems 2024-11-25 Manon Dausort , Tiffanie Godelaine , Maxime Zanella , Karim El Khoury , Isabelle Salmon , Benoît Macq

Cytology is essential for cancer diagnostics and screening due to its minimally invasive nature. However, the development of robust deep learning models for digital cytology is challenging due to the heterogeneity in staining and…

Computer Vision and Pattern Recognition · Computer Science 2025-04-21 Vedrana Ivezić , Ashwath Radhachandran , Ekaterina Redekop , Shreeram Athreya , Dongwoo Lee , Vivek Sant , Corey Arnold , William Speier

Deep learning underlies most modern approaches and tools in computer vision, including biomedical imaging. However, for interactive semantic segmentation (often called pixel classification in this context) and interactive object-level…

Computer Vision and Pattern Recognition · Computer Science 2026-03-23 Carolin Teuber , Anwai Archit , Tobias Boothe , Peter Ditte , Jochen Rink , Constantin Pape

Cancers are characterized by remarkable heterogeneity and diverse prognosis. Accurate cancer classification is essential for patient stratification and clinical decision-making. Although digital pathology has been advancing cancer diagnosis…

Computer Vision and Pattern Recognition · Computer Science 2025-02-13 Xiaofei Wang , Hanyu Liu , Yupei Zhang , Boyang Zhao , Hao Duan , Wanming Hu , Yonggao Mou , Stephen Price , Chao Li

The core of video-based visible-infrared person re-identification (VVI-ReID) lies in learning sequence-level modal-invariant representations across different modalities. Recent research tends to use modality-shared language prompts…

Computer Vision and Pattern Recognition · Computer Science 2026-01-21 Xiaomei Yang , Xizhan Gao , Antai Liu , Kang Wei , Fa Zhu , Guang Feng , Xiaofeng Qu , Sijie Niu

Accurate segmentation of laryngo-pharyngeal tumors is crucial for precise diagnosis and effective treatment planning. However, traditional single-modality imaging methods often fall short of capturing the complex anatomical and pathological…

Image and Video Processing · Electrical Eng. & Systems 2025-08-26 Junhao Wu , Yun Li , Junhao Li , Jingliang Bian , Xiaomao Fan , Wenbin Lei , Ruxin Wang

Multimodal Large Language Models (MLLMs) have demonstrated remarkable potential in medical image analysis. However, their application in gastrointestinal endoscopy is currently hindered by two critical limitations: the misalignment between…

Computer Vision and Pattern Recognition · Computer Science 2026-04-10 Huan Zheng , Yucheng Zhou , Tianyi Yan , Dubing Chen , Hongbo Lu , Wenlong Liao , Tao He , Pai Peng , Jianbing Shen