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Delineation of cancerous regions in gigapixel whole slide images (WSIs) is a crucial diagnostic procedure in digital pathology. This process is time-consuming because of the large search space in the gigapixel WSIs, causing chances of…

Image and Video Processing · Electrical Eng. & Systems 2020-07-21 Hsien-Tzu Cheng , Chun-Fu Yeh , Po-Chen Kuo , Andy Wei , Keng-Chi Liu , Mong-Chi Ko , Kuan-Hua Chao , Yu-Ching Peng , Tyng-Luh Liu

The difficulty of processing gigapixel whole slide images (WSIs) in clinical microscopy has been a long-standing barrier to implementing computer aided diagnostic systems. Since modern computing resources are unable to perform computations…

Computer Vision and Pattern Recognition · Computer Science 2020-08-13 Sam Maksoud , Kun Zhao , Peter Hobson , Anthony Jennings , Brian Lovell

Whole Slide Image (WSI) analysis, with its ability to reveal detailed tissue structures in magnified views, plays a crucial role in cancer diagnosis and prognosis. Due to their giga-sized nature, WSIs require substantial storage and…

Computer Vision and Pattern Recognition · Computer Science 2025-08-05 Doanh Cao Bui , Jin Tae Kwak

Histology slide digitization is becoming essential for telepathology (remote consultation), knowledge sharing (education), and using the state-of-the-art artificial intelligence algorithms (augmented/automated end-to-end clinical…

Image and Video Processing · Electrical Eng. & Systems 2024-05-15 Talat Zehra , Joseph Marino , Wendy Wang , Grigoriy Frantsuzov , Saad Nadeem

Automated whole slide image (WSI) tagging has become a growing demand due to the increasing volume and diversity of WSIs collected nowadays in histopathology. Various methods have been studied to classify WSIs with single tags but none of…

Computer Vision and Pattern Recognition · Computer Science 2019-07-05 Weijian Li , Viet-Duy Nguyen , Haofu Liao , Matt Wilder , Ke Cheng , Jiebo Luo

Wi-Fi sensing is a transformative approach that enables a large of applications through CSI analysis. The challenge lies in the high computational and communication costs with the increasing granularity of CSI data. In this letter, we…

Signal Processing · Electrical Eng. & Systems 2024-05-08 Jichen Bian

Whole slide images (WSIs) are high-resolution, gigapixel sized images that pose significant computational challenges for traditional machine learning models due to their size and heterogeneity.In this paper, we present a scalable and…

Computer Vision and Pattern Recognition · Computer Science 2025-01-22 Ravi Kant Gupta , Shounak Das , Ardhendu Sekhar , Amit Sethi

Whole-slide image (WSI) analysis remains challenging due to the gigapixel scale and sparsely distributed diagnostic regions. Multiple Instance Learning (MIL) mitigates this by modeling the WSI as bags of patches for slide-level prediction.…

Computer Vision and Pattern Recognition · Computer Science 2025-08-05 Yujian Liu , Yuechuan Lin , Dongxu Shen , Haoran Li , Yutong Wang , Xiaoli Liu , Shidang Xu

In pre-clinical pathology, there is a paradox between the abundance of raw data (whole slide images from many organs of many individual animals) and the lack of pixel-level slide annotations done by pathologists. Due to time constraints and…

Computer Vision and Pattern Recognition · Computer Science 2023-02-06 Marco Bertolini , Van-Khoa Le , Jake Pencharz , Andreas Poehlmann , Djork-Arné Clevert , Santiago Villalba , Floriane Montanari

Multiple instance learning (MIL) has been widely used for representing whole-slide pathology images. However, spatial, semantic, and decision entanglements among instances limit its representation and interpretability. To address these…

Computer Vision and Pattern Recognition · Computer Science 2025-11-05 Chentao Li , Behzad Bozorgtabar , Yifang Ping , Pan Huang , Jing Qin

Deep learning has shown strong potential in cancer classification from whole-slide images (WSIs), but the need for extensive expert annotations often limits its success. Annotation-free approaches, such as multiple instance learning (MIL)…

Computer Vision and Pattern Recognition · Computer Science 2026-03-12 Willmer Rafell Quinones Robles , Sakonporn Noree , Jongwoo Kim , Young Sin Ko , Bryan Wong , Mun Yong Yi

Given the special situation of modeling gigapixel images, multiple instance learning (MIL) has become one of the most important frameworks for Whole Slide Image (WSI) classification. In current practice, most MIL networks often face two…

Computer Vision and Pattern Recognition · Computer Science 2024-01-11 Pei Liu , Luping Ji , Xinyu Zhang , Feng Ye

The advancement of digital pathology, particularly through computational analysis of whole slide images (WSI), is poised to significantly enhance diagnostic precision and efficiency. However, the large size and complexity of WSIs make it…

Computer Vision and Pattern Recognition · Computer Science 2024-11-14 Ravi Kant Gupta , Dadi Dharani , Shambhavi Shanker , Amit Sethi

Multiple Instance Learning (MIL) has emerged as a promising paradigm for Whole Slide Image (WSI) diagnosis, offering effective learning with limited annotations. However, existing MIL frameworks overlook diagnostic priorities and fail to…

Computer Vision and Pattern Recognition · Computer Science 2026-03-17 Sungrae Hong , Jiwon Jeong , Jisu Shin , Donghee Han , Sol Lee , Kyungeun Kim , Mun Yong Yi

Multiple Instance Learning (MIL) methods have succeeded remarkably in histopathology whole slide image (WSI) analysis. However, most MIL models only offer attention-based explanations that do not faithfully capture the model's decision…

Computer Vision and Pattern Recognition · Computer Science 2025-07-17 Susu Sun , Dominique van Midden , Geert Litjens , Christian F. Baumgartner

Representation learning from Gigapixel Whole Slide Images (WSI) poses a significant challenge in computational pathology due to the complicated nature of tissue structures and the scarcity of labeled data. Multi-instance learning methods…

Image and Video Processing · Electrical Eng. & Systems 2024-05-28 Ali Nasiri-Sarvi , Vincent Quoc-Huy Trinh , Hassan Rivaz , Mahdi S. Hosseini

Purpose: In this work, we present a collaboration to create a validation dataset of pathologist annotations for algorithms that process whole slide images (WSIs). We focus on data collection and evaluation of algorithm performance in the…

We propose a new method for cancer subtype classification from histopathological images, which can automatically detect tumor-specific features in a given whole slide image (WSI). The cancer subtype should be classified by referring to a…

Computer Vision and Pattern Recognition · Computer Science 2020-04-03 Noriaki Hashimoto , Daisuke Fukushima , Ryoichi Koga , Yusuke Takagi , Kaho Ko , Kei Kohno , Masato Nakaguro , Shigeo Nakamura , Hidekata Hontani , Ichiro Takeuchi

While Large Language Models (LLMs) are emerging as a promising direction in computational pathology, the substantial computational cost of giga-pixel Whole Slide Images (WSIs) necessitates the use of Multi-Instance Learning (MIL) to enable…

Computer Vision and Pattern Recognition · Computer Science 2025-11-12 Zhenfeng Zhuang , Fangyu Zhou , Liansheng Wang

Multiple Instance Learning (MIL) has advanced WSI analysis but struggles with the complexity and heterogeneity of WSIs. Existing MIL methods face challenges in aggregating diverse patch information into robust WSI representations. While…

Computer Vision and Pattern Recognition · Computer Science 2025-07-28 Beidi Zhao , SangMook Kim , Hao Chen , Chen Zhou , Zu-hua Gao , Gang Wang , Xiaoxiao Li