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Related papers: Active Liquid-Liquid Phase-Separation in a Confini…

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Droplet formation has emerged as an essential concept for the spatiotemporal organisation of biomolecules in cells. However, classical descriptions of droplet dynamics based on passive liquid-liquid phase separation cannot capture the…

Biological Physics · Physics 2025-11-14 David Zwicker , Oliver W. Paulin , Cathelijne ter Burg

Liquid liquid phase separation (LLPS) mediated by pi-cation bonds between tyrosine and arginine residues are of biological importance. To understand the interactions between proteins in the condensed phase in close analogy to complex…

Biological Physics · Physics 2020-08-19 Aditya N. Singh , Arun Yethiraj

Multicanonical ensemble sampling simulations have been performed to calculate the phase diagram of a Lennard-Jones fluid embedded in a fractal random matrix generated through diffusion limited cluster aggregation. The study of the system at…

Statistical Mechanics · Physics 2015-06-25 V. De Grandis , P. Gallo , M. Rovere

The energy landscape dictates pathways and outcomes in supramolecular selfassembly, yet harnessing it from the nano to the macro scales remains a major challenge. Here, we demonstrate liquid liquid phase separation (LLPS) as a powerful tool…

Water's unique anomalies are vital in various applications and biological processes, yet the molecular mechanisms behind these anomalies remain debated, particularly in the metastable liquid phase under supercooling and stretching…

Statistical Mechanics · Physics 2024-05-17 Luis Enrique Coronas , Giancarlo Franzese

In this paper, we bring together our efforts in identifying and understanding nonequilibrium phase segregation driven by active processes in the living cell, with special focus on the segregation of cell membrane components driven by active…

Soft Condensed Matter · Physics 2022-05-04 Ajay Bansal , Amit Das , Madan Rao

Classical nucleation theory (CNT), linking rare nucleation events to the free energy landscape of a growing nucleus, is central to understanding phase-change kinetics in passive fluids. Nucleation in non-equilibrium systems is much harder…

Soft Condensed Matter · Physics 2023-03-15 M. E. Cates , C. Nardini

In thermodynamic equilibrium, the fluctuation-dissipation theorem links thermal fluctuations and dissipation. Biological systems, however, are driven out of equilibrium by internal processes that produce additional, active fluctuations.…

Soft Condensed Matter · Physics 2026-01-29 Ashot Matevosyan , Frank Jülicher , Ricard Alert

Phase separation in confined environments is a fundamental process underlying geological flows, porous filtration, emulsions, and intracellular organization. Yet, how confinement and activity jointly govern coarsening kinetics and…

Soft Condensed Matter · Physics 2025-12-11 Preethi M , Parameshwaran A , Bhaskar Sen Gupta

We present a comprehensive study about the relationship between the way Detailed Balance is broken in non-equilibrium systems and the resulting violations of the Fluctuation-Dissipation Theorem. Starting from stochastic dynamics with both…

Statistical Mechanics · Physics 2020-07-16 Sara Dal Cengio , Demian Levis , Ignacio Pagonabarraga

Liquid-liquid phase separation is important across biology, physics, and materials science. Although usually studied at equilibrium, active components - such as motor proteins, enzymes, and synthetic microswimmers - are increasingly…

Soft Condensed Matter · Physics 2026-01-06 Kan Chang , Yulin Li , Ming Yuan , Masaki Sano , Zhihong You , H. P. Zhang

Liquid-liquid phase separation of aqueous two-phase system (ATPS) is fundamental across physical and biological sciences. While well understood for passive systems, how this process is regulated by active agents such as motile bacteria…

Soft Condensed Matter · Physics 2025-11-25 Dixi Yang , Anheng Wang , Chunming Wang , Hajime Tanaka , Jiaxing Yuan

In this paper we present a review on our recent experimental investigations into the phase behavior of the deeply cooled water confined in a nanoporous silica material, MCM-41, with elastic neutron scattering technique. Under such strong…

Soft Condensed Matter · Physics 2016-12-13 Zhe Wang , Kanae Ito , Sow-Hsin Chen

Liquid-gas phase coexistence in a boundary-driven diffusive system is studied by analyzing fluctuating hydrodynamics of a density field defined on a one-dimensional lattice with a space interval $\Lambda$. When an interface width $\ell$ is…

Statistical Mechanics · Physics 2024-11-28 Shin-ichi Sasa , Naoko Nakagawa

The physical chemistry of liquid-liquid phase separation (LLPS) of polymer solutions bears directly on the assembly of biologically functional droplet-like bodies from proteins and nucleic acids. These biomolecular condensates include…

Biomolecules · Quantitative Biology 2020-01-31 Yi-Hsuan Lin , Jacob P. Brady , Hue Sun Chan , Kingshuk Ghosh

Motility-induced phase separation (MIPS), the phenomenon in which purely repulsive active particles undergo a liquid-gas phase separation, is among the simplest and most widely studied examples of a nonequilibrium phase transition. Here, we…

Soft Condensed Matter · Physics 2021-05-11 Ahmad K. Omar , Katherine Klymko , Trevor GrandPre , Phillip L. Geissler

Flow transport in confined spaces is ubiquitous in technological processes, ranging from separation and purification of pharmaceutical ingredients by microporous membranes and drug delivery in biomedical treatment to chemical and biomass…

Soft Condensed Matter · Physics 2021-01-01 Xuehua Zhang , Jae Bem You , Gilmar F. Arends , Jiasheng Qian , Yibo Chen , Detlef Lohse , John M. Shaw

In ABP systems, phase separation is accompanied by the emergence of vapor bubbles within liquid domains. Using large-scale particle-based simulations, we study the stochastic dynamics of these bubbles and find that most nucleate, grow, and…

Soft Condensed Matter · Physics 2025-01-22 Mingqi Yan , Erwin Frey , Marcus Müller , Stefan Klumpp

Confinement can have a dramatic effect on the behavior of all sorts of particulate systems and it therefore is an important phenomenon in many different areas of physics and technology. Here, we investigate the role played by the softness…

The interplay between phase separation and wetting of multicomponent mixtures is ubiquitous in nature and technology and recently gained significant attention across scientific disciplines, due to the discovery of biomolecular condensates.…

Soft Condensed Matter · Physics 2022-10-14 Youchuang Chao , Olinka Ramirez-Soto , Christian Bahr , Stefan Karpitschka