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Continuous chain-of-thought has been shown to be effective in saving reasoning tokens for large language models. By reasoning with continuous latent thought tokens, continuous CoT is able to perform implicit reasoning in a compact manner.…

Computation and Language · Computer Science 2026-02-27 Haoyi Wu , Zhihao Teng , Kewei Tu

Protein language models (pLMs) have recently gained significant attention for their ability to uncover relationships between sequence, structure, and function from evolutionary statistics, thereby accelerating therapeutic drug discovery.…

Machine Learning · Computer Science 2026-03-04 Darshan Patil , Pranshu Malviya , Mathieu Reymond , Quentin Fournier , Sarath Chandar

Tokenization strategies shape how models process electronic health records, yet fair comparisons of their effectiveness remain limited. We present a systematic evaluation of tokenization approaches for clinical time series modeling using…

Machine Learning · Computer Science 2025-12-08 Rafi Al Attrach , Rajna Fani , David Restrepo , Yugang Jia , Peter Schüffler

Process data, temporally ordered categorical observations, are of recent interest due to its increasing abundance and the desire to extract useful information. A process is a collection of time-stamped events of different types, recording…

Methodology · Statistics 2025-01-08 Guanhua Fang , Zhiliang Ying

In this study, we generate and maintain a database of 10 million virtual lipids through METiS's in-house de novo lipid generation algorithms and lipid virtual screening techniques. These virtual lipids serve as a corpus for pre-training,…

Computation and Language · Computer Science 2025-05-06 Tianhao Yu , Cai Yao , Zhuorui Sun , Feng Shi , Lin Zhang , Kangjie Lyu , Xuan Bai , Andong Liu , Xicheng Zhang , Jiali Zou , Wenshou Wang , Chris Lai , Kai Wang

Representing continuous time is a critical and under-explored challenge in modeling temporal event sequences with large language models (LLMs). Various strategies like byte-level representations or calendar tokens have been proposed.…

Computation and Language · Computer Science 2026-05-12 Zefang Liu , Nam H. Nguyen , Yinzhu Quan , Shi-Xiong Zhang

Complex numerical time series analysis often demands multi-step reasoning capabilities beyond current models' reach. Tasks like medical diagnosis and weather forecasting require sequential reasoning processes - including counterfactual…

Machine Learning · Computer Science 2026-03-17 Felix Parker , Nimeesha Chan , Chi Zhang , Kimia Ghobadi

Recent advances in End-to-End (E2E) Spoken Language Understanding (SLU) have been primarily due to effective pretraining of speech representations. One such pretraining paradigm is the distillation of semantic knowledge from…

Computation and Language · Computer Science 2022-07-04 Vishal Sunder , Eric Fosler-Lussier , Samuel Thomas , Hong-Kwang J. Kuo , Brian Kingsbury

Peptide sequencing-the process of identifying amino acid sequences from mass spectrometry data-is a fundamental task in proteomics. Non-Autoregressive Transformers (NATs) have proven highly effective for this task, outperforming traditional…

Biomolecules · Quantitative Biology 2025-06-17 Xiang Zhang , Jiaqi Wei , Zijie Qiu , Sheng Xu , Nanqing Dong , Zhiqiang Gao , Siqi Sun

Neural network models using predictive coding are interesting from the viewpoint of computational modelling of human language acquisition, where the objective is to understand how linguistic units could be learned from speech without any…

Computation and Language · Computer Science 2020-07-09 María Andrea Cruz Blandón , Okko Räsänen

Time series generation is a crucial research topic in the area of decision-making systems, which can be particularly important in domains like autonomous driving, healthcare, and, notably, robotics. Recent approaches focus on learning in…

Machine Learning · Computer Science 2024-09-16 Jian Qian , Bingyu Xie , Biao Wan , Minhao Li , Miao Sun , Patrick Yin Chiang

Change Point Detection (CPD) methods identify the times associated with changes in the trends and properties of time series data in order to describe the underlying behaviour of the system. For instance, detecting the changes and anomalies…

Machine Learning · Computer Science 2021-03-08 Shohreh Deldari , Daniel V. Smith , Hao Xue , Flora D. Salim

In research areas with scarce data, representation learning plays a significant role. This work aims to enhance representation learning for clinical time series by deriving universal embeddings for clinical features, such as heart rate and…

Machine Learning · Computer Science 2024-02-07 Yurong Hu , Manuel Burger , Gunnar Rätsch , Rita Kuznetsova

Self-supervised learning has garnered increasing attention in time series analysis for benefiting various downstream tasks and reducing reliance on labeled data. Despite its effectiveness, existing methods often struggle to comprehensively…

Machine Learning · Computer Science 2025-06-12 Daoyu Wang , Mingyue Cheng , Zhiding Liu , Qi Liu

We introduce the Temporal Contrastive Transformer (TCT), a representation learning framework designed to capture contextual temporal dynamics in sequences of financial transactions. The model is trained using a self-supervised contrastive…

Machine Learning · Computer Science 2026-05-22 Danny Butvinik , Yonit Marcus , Nitzan Tal , Gabrielle Azoulay

We consider the problem of data-driven predictive control for an unknown discrete-time linear time-periodic (LTP) system of known period. Our proposed strategy generalizes both Data-enabled Predictive Control (DeePC) and Subspace Predictive…

Systems and Control · Electrical Eng. & Systems 2022-09-13 Ruiqi Li , John W. Simpson-Porco , Stephen L. Smith

Lipreading is the task of decoding text from the movement of a speaker's mouth. Traditional approaches separated the problem into two stages: designing or learning visual features, and prediction. More recent deep lipreading approaches are…

Machine Learning · Computer Science 2016-12-19 Yannis M. Assael , Brendan Shillingford , Shimon Whiteson , Nando de Freitas

Large language models are increasingly used in social sciences, but their training data can introduce lookahead bias and training leakage. A good chronologically consistent language model requires efficient use of training data to maintain…

General Finance · Quantitative Finance 2025-07-08 Songrun He , Linying Lv , Asaf Manela , Jimmy Wu

The field of Natural Language Processing (NLP) is currently undergoing a revolutionary transformation driven by the power of pre-trained Large Language Models (LLMs) based on groundbreaking Transformer architectures. As the frequency and…

The diverse nature of protein prediction tasks has traditionally necessitated specialized models, hindering the development of broadly applicable and computationally efficient Protein Language Models (PLMs). In this work, we introduce…