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Protein language models (PLMs) have emerged as powerful tools to detect complex patterns of protein sequences. However, the capability of PLMs to fully capture information on protein sequences might be limited by focusing on single…

Machine Learning · Computer Science 2025-05-27 Hazem Alsamkary , Mohamed Elshaffei , Mohamed Elkerdawy , Ahmed Elnaggar

Pre-training has shown success in different areas of machine learning, such as Computer Vision, Natural Language Processing (NLP), and medical imaging. However, it has not been fully explored for clinical data analysis. An immense amount of…

Machine Learning · Computer Science 2023-07-18 Chantal Pellegrini , Nassir Navab , Anees Kazi

Less than 1% of protein sequences are structurally and functionally annotated. Natural Language Processing (NLP) community has recently embraced self-supervised learning as a powerful approach to learn representations from unlabeled text,…

Biomolecules · Quantitative Biology 2020-12-08 Modestas Filipavicius , Matteo Manica , Joris Cadow , Maria Rodriguez Martinez

Genomic selection (GS), as a critical crop breeding strategy, plays a key role in enhancing food production and addressing the global hunger crisis. The predominant approaches in GS currently revolve around employing statistical methods for…

Machine Learning · Computer Science 2024-06-25 Renqi Chen , Wenwei Han , Haohao Zhang , Haoyang Su , Zhefan Wang , Xiaolei Liu , Hao Jiang , Wanli Ouyang , Nanqing Dong

In the intersection of molecular science and deep learning, tasks like virtual screening have driven the need for a high-throughput molecular representation generator on large chemical databases. However, as SMILES strings are the most…

Computational Engineering, Finance, and Science · Computer Science 2021-12-28 Wenhao Zhu , Ziyao Li , Lingsheng Cai , Guojie Song

Diffusion (Large) Language Models (dLLMs) now match the downstream performance of their autoregressive counterparts on many tasks, while holding the promise of being more efficient during inference. One critical design aspect of dLLMs is…

Cross-lingual transfer learning is an important property of multilingual large language models (LLMs). But how do LLMs represent relationships between languages? Every language model has an input layer that maps tokens to vectors. This…

Computation and Language · Computer Science 2023-12-19 Andrea W Wen-Yi , David Mimno

While large language models (LLMs) have been successfully applied to various tasks, they still face challenges with hallucinations. Augmenting LLMs with domain-specific tools such as database utilities can facilitate easier and more precise…

Computation and Language · Computer Science 2024-04-10 Qiao Jin , Yifan Yang , Qingyu Chen , Zhiyong Lu

Protein Language Models (PLMs) have emerged as performant and scalable tools for predicting the functional impact and clinical significance of protein-coding variants, but they still lag experimental accuracy. Here, we present a novel…

This paper presents a novel hybrid tokenization strategy that enhances the performance of DNA Language Models (DLMs) by combining 6-mer tokenization with Byte Pair Encoding (BPE-600). Traditional k-mer tokenization is effective at capturing…

Computation and Language · Computer Science 2025-07-25 Ganesh Sapkota , Md Hasibur Rahman

Language Models like ELMo and BERT have provided robust representations of natural language, which serve as the language understanding component for a diverse range of downstream tasks.Curriculum learning is a method that employs a…

Computation and Language · Computer Science 2021-08-05 Daniel Campos

Large language models (LLMs) have revolutionized lots of fields of research. Although it is well-known that fine-tuning is essential for enhancing the capabilities of LLMs, existing research suggests that there is potential redundancy in…

Artificial Intelligence · Computer Science 2025-02-14 Haoling Li , Xin Zhang , Xiao Liu , Yeyun Gong , Yifan Wang , Qi Chen , Peng Cheng

Software Engineering (SE) Pre-trained Language Models (PLMs), such as CodeBERT, are pre-trained on large code corpora, and their learned knowledge has shown success in transferring into downstream tasks (e.g., code clone detection) through…

Software Engineering · Computer Science 2024-02-07 Iman Saberi , Fatemeh Fard , Fuxiang Chen

Bidirectional Encoder Representations from Transformers (BERT) has shown marvelous improvements across various NLP tasks, and consecutive variants have been proposed to further improve the performance of the pre-trained language models. In…

Computation and Language · Computer Science 2020-12-14 Yiming Cui , Wanxiang Che , Ting Liu , Bing Qin , Shijin Wang , Guoping Hu

There is a growing interest in utilizing large-scale language models (LLMs) to advance next-generation Recommender Systems (RecSys), driven by their outstanding language understanding and in-context learning capabilities. In this scenario,…

Information Retrieval · Computer Science 2025-08-18 Haohao Qu , Wenqi Fan , Zihuai Zhao , Qing Li

Large language models (LLMs) are having transformative impacts across a wide range of scientific fields, particularly in the biomedical sciences. Just as the goal of Natural Language Processing is to understand sequences of words, a major…

Genomics · Quantitative Biology 2024-09-24 Gonzalo Benegas , Chengzhong Ye , Carlos Albors , Jianan Canal Li , Yun S. Song

Training wide and deep neural networks (DNNs) require large amounts of storage resources such as memory because the intermediate activation data must be saved in the memory during forward propagation and then restored for backward…

Artificial Intelligence · Computer Science 2021-11-19 Sian Jin , Chengming Zhang , Xintong Jiang , Yunhe Feng , Hui Guan , Guanpeng Li , Shuaiwen Leon Song , Dingwen Tao

Large Language Models (LLMs) demonstrate remarkable generalizability across diverse tasks, yet genomic foundation models (GFMs) still require separate finetuning for each downstream application, creating significant overhead as model sizes…

Genomics · Quantitative Biology 2025-02-07 Zehui Li , Vallijah Subasri , Yifei Shen , Dongsheng Li , Yiren Zhao , Guy-Bart Stan , Caihua Shan

The emergence of large language models (LLMs) has significantly transformed natural language processing (NLP), enabling more generalized models to perform various tasks with minimal training. However, traditional sentiment analysis methods,…

Computation and Language · Computer Science 2026-01-13 Keito Inoshita , Xiaokang Zhou , Akira Kawai

Pre-trained models are widely used in the tasks of natural language processing nowadays. However, in the specific field of text simplification, the research on improving pre-trained models is still blank. In this work, we propose a…

Computation and Language · Computer Science 2022-04-19 Renliang Sun , Xiaojun Wan
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