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Deep graph learning has advanced Alzheimer's (AD) disease classification from MRI, but most models remain correlational, confounding demographic and genetic factors with disease specific features. We present Causal-GCN, an interventional…

Machine Learning · Computer Science 2025-11-20 Pranay Kumar Peddi , Dhrubajyoti Ghosh

Alzheimer's disease detection requires expensive neuroimaging or invasive procedures, limiting accessibility. This study explores whether deep learning can enable non-invasive Alzheimer's disease detection through handwriting analysis.…

Image and Video Processing · Electrical Eng. & Systems 2025-08-19 Emanuele Nardone , Tiziana D'Alessandro , Francesco Fontanella , Claudio De Stefano

Alzheimer's disease (AD) is known as one of the major causes of dementia and is characterized by slow progression over several years, with no treatments or available medicines. In this regard, there have been efforts to identify the risk of…

Computer Vision and Pattern Recognition · Computer Science 2020-08-28 Wonsik Jung , Eunji Jun , Heung-Il Suk

Alzheimer's Disease (AD) is a complex neurodegenerative disorder marked by memory loss, executive dysfunction, and personality changes. Early diagnosis is challenging due to subtle symptoms and varied presentations, often leading to…

Computer Vision and Pattern Recognition · Computer Science 2025-01-06 Yifei Chen , Shenghao Zhu , Zhaojie Fang , Chang Liu , Binfeng Zou , Yuhe Wang , Shuo Chang , Fan Jia , Feiwei Qin , Jin Fan , Yong Peng , Changmiao Wang

Quantification of anatomical shape changes currently relies on scalar global indexes which are largely insensitive to regional or asymmetric modifications. Accurate assessment of pathology-driven anatomical remodeling is a crucial step for…

Medical imaging spans diverse tasks and modalities which play a pivotal role in disease diagnosis, treatment planning, and monitoring. This study presents a novel exploration, being the first to systematically evaluate segmentation,…

Image and Video Processing · Electrical Eng. & Systems 2025-02-27 Anyimadu Daniel Tweneboah , Suleiman Taofik Ahmed , Hossain Mohammad Imran

Alzheimer's disease is the most common dementia leading to an irreversible neurodegenerative process. To date, subject revealed advanced brain structural alterations when the diagnosis is established. Therefore, an earlier diagnosis of this…

Computer Vision and Pattern Recognition · Computer Science 2018-07-10 Kilian Hett , Vinh-Thong Ta , Jose Vicente Manjon , Pierrick Coupé

The current state-of-the-art deep neural networks (DNNs) for Alzheimer's Disease diagnosis use different biomarker combinations to classify patients, but do not allow extracting knowledge about the interactions of biomarkers. However, to…

Machine Learning · Computer Science 2021-09-28 Raphael Ronge , Kwangsik Nho , Christian Wachinger , Sebastian Pölsterl

Heterogeneity of brain diseases is a challenge for precision diagnosis/prognosis. We describe and validate Smile-GAN (SeMI-supervised cLustEring-Generative Adversarial Network), a novel semi-supervised deep-clustering method, which dissects…

Multiple studies have demonstrated that obtaining standardized fetal brain biometry from mid-trimester ultrasonography (USG) examination is key for the reliable assessment of fetal neurodevelopment and the screening of central nervous…

Research studies have shown no qualms about using data driven deep learning models for downstream tasks in medical image analysis, e.g., anatomy segmentation and lesion detection, disease diagnosis and prognosis, and treatment planning.…

Image and Video Processing · Electrical Eng. & Systems 2022-04-06 Jiahao Huang , Yingying Fang , Yang Nan , Huanjun Wu , Yinzhe Wu , Zhifan Gao , Yang Li , Zidong Wang , Pietro Lio , Daniel Rueckert , Yonina C. Eldar , Guang Yang

Background: Alzheimers disease is a progressive neurodegenerative disorder and the main cause of dementia in aging. Hippocampus is prone to changes in the early stages of Alzheimers disease. Detection and observation of the hippocampus…

Image and Video Processing · Electrical Eng. & Systems 2021-06-17 Hossein Yousefi-Banaem , Saber Malekzadeh

In this paper, we describe our method for classification of brain magnetic resonance (MR) images into different abnormalities and healthy classes based on the deep neural network. We propose our method to detect high and low-grade glioma,…

Computer Vision and Pattern Recognition · Computer Science 2017-08-18 Mina Rezaei , Haojin Yang , Christoph Meinel

Despite the impressive advances achieved using deep learning for functional brain activity analysis, the heterogeneity of functional patterns and the scarcity of imaging data still pose challenges in tasks such as identifying neurological…

Image and Video Processing · Electrical Eng. & Systems 2025-05-30 Wenhui Cui , Haleh Akrami , Anand A. Joshi , Richard M. Leahy

We propose a hierarchically structured variational inference model for accurately disentangling observable evidence of disease (e.g. brain lesions or atrophy) from subject-specific anatomy in brain MRIs. With flexible, partially…

Computer Vision and Pattern Recognition · Computer Science 2022-11-17 Anjun Hu , Jean-Pierre R. Falet , Brennan S. Nichyporuk , Changjian Shui , Douglas L. Arnold , Sotirios A. Tsaftaris , Tal Arbel

Structural MRI and PET imaging play an important role in the diagnosis of Alzheimer's disease (AD), showing the morphological changes and glucose metabolism changes in the brain respectively. The manifestations in the brain image of some…

Image and Video Processing · Electrical Eng. & Systems 2023-08-11 Yanteng Zhang , Qizhi Teng , Xiaohai He , Tong Niu , Lipei Zhang , Yan Liu , Chao Ren

Although deep learning (DL) models have shown great success in many medical image analysis tasks, deployment of the resulting models into real clinical contexts requires: (1) that they exhibit robustness and fairness across different…

Computer Vision and Pattern Recognition · Computer Science 2023-03-07 Raghav Mehta , Changjian Shui , Tal Arbel

Alzheimer's disease (AD), a degenerative brain condition, can benefit from early prediction to slow its progression. As the disease progresses, patients typically undergo brain atrophy. Current prediction methods for Alzheimers disease…

Computer Vision and Pattern Recognition · Computer Science 2025-11-27 Xin Honga , Jie Lin , Minghui Wang

Deep learning models have shown strong performance in diagnosing Alzheimer's disease (AD) using neuroimaging data, particularly 18F-FDG PET scans, with training datasets largely composed of North American cohorts such as those in the…

Computer Vision and Pattern Recognition · Computer Science 2025-11-04 Hugo Massaroli , Hernan Chaves , Pilar Anania , Mauricio Farez , Emmanuel Iarussi , Viviana Siless

How will my face look when I get older? Or, for a more challenging question: How will my brain look when I get older? To answer this question one must devise (and learn from data) a multivariate auto-regressive function which given an image…

Image and Video Processing · Electrical Eng. & Systems 2021-10-01 Tian Xia , Agisilaos Chartsias , Chengjia Wang , Sotirios A. Tsaftaris
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