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This paper investigates the capabilities of large language models (LLMs) in formulating and solving decision-making problems using mathematical programming. We first conduct a systematic review and meta-analysis of recent literature to…

Artificial Intelligence · Computer Science 2025-08-26 Mohammad J. Abdel-Rahman , Yasmeen Alslman , Dania Refai , Amro Saleh , Malik A. Abu Loha , Mohammad Yahya Hamed

Designing de novo proteins beyond those found in nature holds significant promise for advancements in both scientific and engineering applications. Current methodologies for protein design often rely on AI-based models, such as surrogate…

Soft Condensed Matter · Physics 2024-02-08 A. Ghafarollahi , M. J. Buehler

Large language models (LLMs) require enormous computing power to pretrain on massive datasets. When limited datasets are available, smaller-sized LLMs are better choice to pretrain (on user-specified datasets) by following the scaling laws…

Machine Learning · Computer Science 2026-03-23 Praveen Rao

Access to large amounts of diverse design solutions can support designers during the early stage of the design process. In this paper, we explore the efficacy of large language models (LLM) in producing diverse design solutions,…

Human-Computer Interaction · Computer Science 2024-05-07 Kevin Ma , Daniele Grandi , Christopher McComb , Kosa Goucher-Lambert

Phenotype-driven gene prioritization is a critical process in the diagnosis of rare genetic disorders for identifying and ranking potential disease-causing genes based on observed physical traits or phenotypes. While traditional approaches…

Quantitative Methods · Quantitative Biology 2024-04-04 Junyoung Kim , Jingye Yang , Kai Wang , Chunhua Weng , Cong Liu

General purpose Large Language Models (LLM) such as the Generative Pretrained Transformer (GPT) and Large Language Model Meta AI (LLaMA) have attracted much attention in recent years. There is strong evidence that these models can perform…

Computation and Language · Computer Science 2024-04-25 Hossein Salami , Brandye Smith-Goettler , Vijay Yadav

Pharmaceutical three-dimensional (3D) printing is an advanced fabrication technology with the potential to enable truly personalised dosage forms. Recent studies have integrated artificial intelligence (AI) to accelerate formulation and…

Artificial Intelligence · Computer Science 2026-05-19 Adeshola Okubena , Yusuf Ali Mohammed , Moe Elbadawi

Can we leverage LLMs to model the process of discovering novel language model (LM) architectures? Inspired by real research, we propose a multi-agent LLM approach that simulates the conventional stages of research, from ideation and…

Artificial Intelligence · Computer Science 2025-06-26 Junyan Cheng , Peter Clark , Kyle Richardson

Large Language Models (LLMs) stand at the forefront of a number of Natural Language Processing (NLP) tasks. Despite the widespread adoption of LLMs in NLP, much of their potential in broader fields remains largely unexplored, and…

Machine Learning · Computer Science 2024-03-11 Zhiqiang Zhong , Kuangyu Zhou , Davide Mottin

Recent advances in protein language models (PLMs) have demonstrated remarkable capabilities in understanding protein sequences. However, the extent to which different model architectures capture antibody-specific biological properties…

Machine Learning · Computer Science 2025-12-11 Mengren , Liu , Yixiang Zhang , Yiming , Zhang

Large language models (LLMs) have demonstrated remarkable abilities in representation learning for program synthesis and understanding tasks. The quality of the learned representations appears to be dictated by the neural scaling laws as a…

Machine Learning · Computer Science 2023-07-13 Erik Nijkamp , Hiroaki Hayashi , Caiming Xiong , Silvio Savarese , Yingbo Zhou

Large Language Models (LLMs) have emerged as powerful tools in the field of Natural Language Processing (NLP) and have recently gained significant attention in the domain of Recommendation Systems (RS). These models, trained on massive…

Information Retrieval · Computer Science 2024-06-19 Likang Wu , Zhi Zheng , Zhaopeng Qiu , Hao Wang , Hongchao Gu , Tingjia Shen , Chuan Qin , Chen Zhu , Hengshu Zhu , Qi Liu , Hui Xiong , Enhong Chen

Large language models (LLMs) have shown potential as tools for scientific discovery. This has engendered growing interest in their use in humanistic disciplines, such as historical linguistics and literary studies. These fields often…

Computation and Language · Computer Science 2026-03-31 Elisabeth Fittschen , Sabrina Li , Tom Lippincott , Leshem Choshen , Craig Messner

Pre-trained large language models (PLMs) underlie most new developments in natural language processing. They have shifted the field from application-specific model pipelines to a single model that is adapted to a wide range of tasks.…

Computation and Language · Computer Science 2023-06-30 Joshua Maynez , Priyanka Agrawal , Sebastian Gehrmann

Large language models (LLMs) have shown remarkable performance on many different Natural Language Processing (NLP) tasks. Prompt engineering plays a key role in adding more to the already existing abilities of LLMs to achieve significant…

Computation and Language · Computer Science 2024-07-25 Shubham Vatsal , Harsh Dubey

Artificial intelligence (AI) is widely deployed to solve problems related to marketing attribution and budget optimization. However, AI models can be quite complex, and it can be difficult to understand model workings and insights without…

Computation and Language · Computer Science 2024-04-23 Yilin Gao , Sai Kumar Arava , Yancheng Li , James W. Snyder

This paper investigates the utilization of Large Language Models (LLMs) for solving complex linguistic puzzles, a domain requiring advanced reasoning and adept translation capabilities akin to human cognitive processes. We explore specific…

Computation and Language · Computer Science 2025-02-04 Zheng-Lin Lin , Yu-Fei Shih , Shu-Kai Hsieh

Large Language Models (LLMs) demonstrate capabilities in code generation, potentially boosting developer productivity. However, their adoption remains limited by high computational costs, among other factors. Small Language Models (SLMs)…

Software Engineering · Computer Science 2025-09-23 Débora Souza , Rohit Gheyi , Lucas Albuquerque , Gustavo Soares , Márcio Ribeiro

Large Language Models (LLMs) have made remarkable advancements in the field of natural language processing. However, their increasing size poses challenges in terms of computational cost. On the other hand, Small Language Models (SLMs) are…

Computation and Language · Computer Science 2023-08-03 Zhen Guo , Peiqi Wang , Yanwei Wang , Shangdi Yu

Recently published work on rephrasing natural text data for pre-training LLMs has shown promising results when combining the original dataset with the synthetically rephrased data. We build upon previous work by replicating existing results…