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Single-cell trajectory analysis aims to reconstruct the biological developmental processes of cells as they evolve over time, leveraging temporal correlations in gene expression. During cellular development, gene expression patterns…

Applications · Statistics 2026-03-30 Junhao Zhu , Kevin Zhang , Zhaolei Zhang , Dehan Kong

This paper studies the unsupervised change point detection problem in time series of networks using the Separable Temporal Exponential-family Random Graph Model (STERGM). Inherently, dynamic network patterns are complex due to dyadic and…

Methodology · Statistics 2025-09-01 Yik Lun Kei , Hangjian Li , Yanzhen Chen , Oscar Hernan Madrid Padilla

Single-cell RNA sequencing (scRNA-seq), especially temporally resolved datasets, enables genome-wide profiling of gene expression dynamics at single-cell resolution across discrete time points. However, current technologies provide only…

Genomics · Quantitative Biology 2025-11-19 Yue Ling , Peiqi Zhang , Zhenyi Zhang , Peijie Zhou

We propose a methodology to sample from time-integrated stochastic bridges, namely random variables defined as $\int_{t_1}^{t_2} f(Y(t))dt$ conditioned on $Y(t_1)\!=\!a$ and $Y(t_2)\!=\!b$, with $a,b\in R$. The Stochastic Collocation Monte…

Computational Finance · Quantitative Finance 2021-11-30 Leonardo Perotti , Lech A. Grzelak

We consider the problem of simulating diffusion bridges, which are diffusion processes that are conditioned to initialize and terminate at two given states. The simulation of diffusion bridges has applications in diverse scientific fields…

Computation · Statistics 2025-06-19 Jeremy Heng , Valentin De Bortoli , Arnaud Doucet , James Thornton

Complex nonlinear dynamics are ubiquitous in many fields. Moreover, we rarely have access to all of the relevant state variables governing the dynamics. Delay embedding allows us, in principle, to account for unobserved state variables.…

Machine Learning · Computer Science 2022-04-27 Uttam Bhat , Stephan B. Munch

Generative models are invaluable in many fields of science because of their ability to capture high-dimensional and complicated distributions, such as photo-realistic images, protein structures, and connectomes. How do we evaluate the…

We develop an approach to learn an interpretable semi-parametric model of a latent continuous-time stochastic dynamical system, assuming noisy high-dimensional outputs sampled at uneven times. The dynamics are described by a nonlinear…

Machine Learning · Statistics 2019-02-13 Lea Duncker , Gergo Bohner , Julien Boussard , Maneesh Sahani

Tree-like structures, such as blood vessels, often express complexity at very fine scales, requiring high-resolution grids to adequately describe their shape. Such sparse morphology can alternately be represented by locations of centreline…

Computer Vision and Pattern Recognition · Computer Science 2018-11-09 Kerry Halupka , Rahil Garnavi , Stephen Moore

The discovery of reusable sub-routines simplifies decision-making and planning in complex reinforcement learning problems. Previous approaches propose to learn such temporal abstractions in a purely unsupervised fashion through observing…

Machine Learning · Computer Science 2022-11-23 Anand Gopalakrishnan , Kazuki Irie , Jürgen Schmidhuber , Sjoerd van Steenkiste

The Dirichlet Belief Network~(DirBN) has been recently proposed as a promising approach in learning interpretable deep latent representations for objects. In this work, we leverage its interpretable modelling architecture and propose a deep…

Machine Learning · Computer Science 2020-04-30 Yaqiong Li , Xuhui Fan , Ling Chen , Bin Li , Zheng Yu , Scott A. Sisson

We consider an evolving system for which a sequence of observations is being made, with each observation revealing additional information about current and past states of the system. We suppose each observation is made without error, but…

Computation · Statistics 2021-03-10 Valentina Di Marco , Jonathan Keith

Single-cell gene expression measurements encode variability spanning molecular noise, cell-to-cell heterogeneity, and technical artifacts. Mechanistic stochastic models provide powerful approaches to disentangle these sources, yet inferring…

Quantitative Methods · Quantitative Biology 2025-09-19 Christopher E. Miles

Imagine a smart camera trap selectively clicking pictures to understand animal movement patterns within a particular habitat. These "snapshots", or pieces of data captured from a data stream at adaptively chosen times, provide a glimpse of…

Machine Learning · Computer Science 2024-12-10 Pramith Devulapalli , Steve Hanneke

A number of recent self-supervised learning methods have shown impressive performance on image classification and other tasks. A somewhat bewildering variety of techniques have been used, not always with a clear understanding of the reasons…

Computer Vision and Pattern Recognition · Computer Science 2022-07-11 Suhong Moon , Domas Buracas , Seunghyun Park , Jinkyu Kim , John Canny

We introduce Schroedinger Eigenmaps, a new semi-supervised manifold learning and recovery technique. This method is based on an implementation of graph Schroedinger operators with appropriately constructed barrier potentials as carriers of…

Computational Engineering, Finance, and Science · Computer Science 2017-09-04 Wojciech Czaja , Martin Ehler

We present Schr\"odinger Bridge Mamba (SBM), a novel model for efficient speech enhancement by integrating the Schr\"odinger Bridge (SB) training paradigm and the Mamba architecture. Experiments of joint denoising and dereverberation tasks…

Sound · Computer Science 2026-03-06 Jing Yang , Sirui Wang , Chao Wu , Lei Guo , Fan Fan

Self-supervised learning achieves superior performance in many domains by extracting useful representations from the unlabeled data. However, most of traditional self-supervised methods mainly focus on exploring the inter-sample structure…

Machine Learning · Computer Science 2020-11-30 Haoyi Fan , Fengbin Zhang , Yue Gao

This paper explores a new research problem of unsupervised transfer learning across multiple spatiotemporal prediction tasks. Unlike most existing transfer learning methods that focus on fixing the discrepancy between supervised tasks, we…

Machine Learning · Computer Science 2020-09-25 Zhiyu Yao , Yunbo Wang , Mingsheng Long , Jianmin Wang

Markov jump processes and continuous time Bayesian networks are important classes of continuous time dynamical systems. In this paper, we tackle the problem of inferring unobserved paths in these models by introducing a fast auxiliary…

Methodology · Statistics 2012-02-20 Vinayak Rao , Yee Whye Teh