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The essential ingredient for studying the phenomena of emergence is the ability to generate and manipulate emergent systems that span large scales. Cellular automata are the model class particularly known for their effective scalability but…

Neural and Evolutionary Computing · Computer Science 2023-06-13 Sina Khajehabdollahi , Emmanouil Giannakakis , Victor Buendia , Georg Martius , Anna Levina

Many biological systems collectively construct complex, adaptive, and functional architectures, where function emerges from bottom-up building processes rather than top-down planning or centralized control. However, general strategies for…

Soft Condensed Matter · Physics 2026-04-15 Andrew Slezak , Varda F. Hagh

Since its introduction in 1952, Turing's (pre-)pattern theory ("the chemical basis of morphogenesis") has been widely applied to a number of areas in developmental biology. The related pattern formation models normally comprise a system of…

Cell Behavior · Quantitative Biology 2020-10-28 Fiona R Macfarlane , Mark AJ Chaplain , Tommaso Lorenzi

Despite simplicity, the synchronous cellular automaton [D.A. Young, Math. Biosci. 72, 51 (1984)] enables reconstructing basic features of patterns of skin. Our extended model allows studying the formatting of patterns and their temporal…

Cell Behavior · Quantitative Biology 2018-07-12 R. Piasecki , W. Olchawa , K. Smaga

We propose a three dimensional mechanical model of embryonic tissue dynamics. Mechanically coupled adherent cells are represented as particles interconnected with elastic beams which can exert non-central forces and torques. Tissue…

Biological Physics · Physics 2015-06-22 Andras Czirok , Dona Greta Isai

Modular Active Cell Robots (MACROs) are a design paradigm for modular robotic hardware that uses only two components, namely actuators and passive compliant joints. Under the MACRO approach, a large number of actuators and joints are…

Robotics · Computer Science 2022-03-15 Gaurav Singh , Ahsan Nawroj , Aaron M Dollar

Robots using cellular-like redundant binary actuators could outmatch electric-gearmotor robotic systems in terms of reliability, force-to-weight ratio and cost. This paper presents a robust fault tolerant control scheme that is designed to…

Robotics · Computer Science 2024-07-26 Alexandre Girard , Jean-Sébastien Plante

Robotic systems operating in unstructured environments require the ability to switch between compliant and rigid states to perform diverse tasks such as adaptive grasping, high-force manipulation, shape holding, and navigation in…

Robotics · Computer Science 2025-09-10 Jianshu Zhou , Wei Chen , Junda Huang , Boyuan Liang , Yunhui Liu , Masayoshi Tomizuka

Active systems across scales, ranging from molecular machines to human crowds, are usually modeled as assemblies of self-propelled particles driven by internally generated forces. However, these models often assume memoryless dynamics and…

Statistical Mechanics · Physics 2025-12-10 Marc Besse , Raphaël Voituriez

The reaction-diffusion models have been extensively applied to explain the mechanism of pattern formations in early embryogenesis based on geometrically confined microtissues consisting of human pluripotent stem cells. Recently, mechanical…

Biological Physics · Physics 2022-11-22 Tiankai Zhao , Hongyan Yuan

This paper proposes a control theoretic framework to model and analyze the self-organized pattern formation of molecular concentrations in biomolecular communication networks, emerging applications in synthetic biology. In biomolecular…

Molecular Networks · Quantitative Biology 2019-01-08 Yutaka Hori , Hiroki Miyazako , Soichiro Kumagai , Shinji Hara

Understanding how living organisms spontaneously develop complex functional structures inspires innovative approaches in engineering design. Here, we introduce a decentralized generative model based on morphogenesis to autonomously grow…

Applied Physics · Physics 2025-09-15 Thomas Fromentèze , Philippe Michaud , Ali Hassny , Vincent Pateloup

Synaptic plasticity dynamically shapes the connectivity of neural systems and is key to learning processes in the brain. To what extent the mechanisms of plasticity can be exploited to drive a neural network and make it perform some kind of…

Neurons and Cognition · Quantitative Biology 2024-12-03 Francesco Borra , Simona Cocco , Rémi Monasson

We introduce a model for describing the dynamics of large numbers of interacting cells. The fundamental dynamical variables in the model are sub-cellular elements, which interact with each other through phenomenological intra- and…

Quantitative Methods · Quantitative Biology 2007-05-23 T. J. Newman

Unlike most human-engineered systems, many biological systems rely on emergent behaviors from low-level interactions, enabling greater diversity and superior adaptation to complex, dynamic environments. This study explores emergent…

Robotics · Computer Science 2024-09-24 Trevor Smith , Yu Gu

The polarisation of cells and tissues is fundamental for tissue morphogenesis during biological development and regeneration. A deeper understanding of biological polarity pattern formation can be gained from the consideration of pattern…

Cell Behavior · Quantitative Biology 2017-10-23 Karl B. Hoffmann , Anja Voss-Böhme , Jochen C. Rink , Lutz Brusch

Motor-proteins are responsible for transport inside cells. Harnessing their activity is key towards developing new nano-technologies, or functional biomaterials. Cytoskeleton-like networks, recently tailored in vitro, result from the…

Soft Condensed Matter · Physics 2016-06-21 Pau Guillamat , Jordi Ignés-Mullol , Francesc Sagués

Biological cells are the prototypical example of active matter. Cells sense and respond to mechanical, chemical and electrical environmental stimuli with a range of behaviors, including dynamic changes in morphology and mechanical…

Computational Engineering, Finance, and Science · Computer Science 2017-02-28 Endre Somogyi , James A. Glazier

Topology optimization is a powerful tool utilized in various fields for structural design. However, its application has primarily been restricted to static or passively moving objects, mainly focusing on hard materials with limited…

Computational Engineering, Finance, and Science · Computer Science 2023-06-30 Changyoung Yuhn , Yuki Sato , Hiroki Kobayashi , Atsushi Kawamoto , Tsuyoshi Nomura

Equipping robotic systems with the capacity to generate $\textit{ex novo}$ hardware during operation extends control of physical adaptability. Unlike modular systems that rely on discrete component integration pre- or post-deployment, we…

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