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Digital pathology and microscopy image analysis are widely employed in the segmentation of digitally scanned IHC slides, primarily to identify cancer and pinpoint regions of interest (ROI) indicative of tumor presence. However, current ROI…

Computer Vision and Pattern Recognition · Computer Science 2024-06-11 Akash Modi , Sumit Kumar Jha , Purnendu Mishra , Rajiv Kumar , Kiran Aatre , Gursewak Singh , Shubham Mathur

Presenting whole slide images (WSIs) as graph will enable a more efficient and accurate learning framework for cancer diagnosis. Due to the fact that a single WSI consists of billions of pixels and there is a lack of vast annotated datasets…

Image and Video Processing · Electrical Eng. & Systems 2023-06-09 Milan Aryal , Nasim Yahyasoltani

The deep neural network is a research hotspot for histopathological image analysis, which can improve the efficiency and accuracy of diagnosis for pathologists or be used for disease screening. The whole slide pathological image can reach…

Image and Video Processing · Electrical Eng. & Systems 2022-05-09 Tingting Zheng , Weixing chen , Shuqin Li , Hao Quan , Qun Bai , Tianhang Nan , Song Zheng , Xinghua Gao , Yue Zhao , Xiaoyu Cui

We propose a new method for cancer subtype classification from histopathological images, which can automatically detect tumor-specific features in a given whole slide image (WSI). The cancer subtype should be classified by referring to a…

Computer Vision and Pattern Recognition · Computer Science 2020-04-03 Noriaki Hashimoto , Daisuke Fukushima , Ryoichi Koga , Yusuke Takagi , Kaho Ko , Kei Kohno , Masato Nakaguro , Shigeo Nakamura , Hidekata Hontani , Ichiro Takeuchi

Histopathological cancer diagnostics has become more complex, and the increasing number of biopsies is a challenge for most pathology laboratories. Thus, development of automatic methods for evaluation of histopathological cancer sections…

Image and Video Processing · Electrical Eng. & Systems 2021-12-08 André Pedersen , Erik Smistad , Tor V. Rise , Vibeke G. Dale , Henrik S. Pettersen , Tor-Arne S. Nordmo , David Bouget , Ingerid Reinertsen , Marit Valla

Advancement in digital pathology and artificial intelligence has enabled deep learning-based computer vision techniques for automated disease diagnosis and prognosis. However, WSIs present unique computational and algorithmic challenges.…

Computer Vision and Pattern Recognition · Computer Science 2021-06-15 Yash Sharma , Lubaina Ehsan , Sana Syed , Donald E. Brown

Whole slide imaging (WSI) refers to the digitization of a tissue specimen which enables pathologists to explore high-resolution images on a monitor rather than through a microscope. The formation of tissue folds occur during tissue…

Image and Video Processing · Electrical Eng. & Systems 2019-03-19 Morteza Babaie , H. R. Tizhoosh

Maximum mean discrepancies (MMDs) like the kernel Stein discrepancy (KSD) have grown central to a wide range of applications, including hypothesis testing, sampler selection, distribution approximation, and variational inference. In each…

Machine Learning · Statistics 2025-03-26 Alessandro Barp , Carl-Johann Simon-Gabriel , Mark Girolami , Lester Mackey

Comparing conditional distributions is a fundamental challenge in statistics and machine learning, with applications across a wide range of domains. While proposed methods for measuring discrepancies using kernel embeddings of distributions…

Machine Learning · Statistics 2026-05-05 Peter Moskvichev , Siu Lun Chau , Dino Sejdinovic

The digitization of histology slides has revolutionized pathology, providing massive datasets for cancer diagnosis and research. Self-supervised and vision-language models have been shown to effectively mine large pathology datasets to…

Whole slide image (WSI) analysis in digital pathology presents unique challenges due to the gigapixel resolution of WSIs and the scarcity of dense supervision signals. While Multiple Instance Learning (MIL) is a natural fit for slide-level…

Computer Vision and Pattern Recognition · Computer Science 2025-08-21 Sofiène Boutaj , Marin Scalbert , Pierre Marza , Florent Couzinie-Devy , Maria Vakalopoulou , Stergios Christodoulidis

Deep convolutional neural networks (CNNs) are the current state-of-the-art for digital analysis of histopathological images. The large size of whole-slide microscopy images (WSIs) requires advanced memory handling to read, display and…

Machine Learning · Computer Science 2020-11-13 André Pedersen , Marit Valla , Anna M. Bofin , Javier Pérez de Frutos , Ingerid Reinertsen , Erik Smistad

Multiple Instance Learning (MIL) for whole slide image (WSI) analysis in computational pathology often neglects instance-level learning as supervision is typically provided only at the bag level, hindering the integrated consideration of…

Computer Vision and Pattern Recognition · Computer Science 2025-09-26 Shuyang Wu , Yifu Qiu , Ines P. Nearchou , Sandrine Prost , Jonathan A. Fallowfield , Hideki Ueno , Hitoshi Tsuda , David J. Harrison , Hakan Bilen , Timothy J. Kendall

We present a pioneering investigation into the application of deep learning techniques to analyze histopathological images for addressing the substantial challenge of automated prognostic prediction. Prognostic prediction poses a unique…

Recent breakthroughs in object detection and image classification using Convolutional Neural Networks (CNNs) are revolutionizing the state of the art in medical imaging, and microscopy in particular presents abundant opportunities for…

Image and Video Processing · Electrical Eng. & Systems 2020-07-07 Rui Aguiar , Jon Braatz

Histology imaging is an essential diagnosis method to finalize the grade and stage of cancer of different tissues, especially for breast cancer diagnosis. Specialists often disagree on the final diagnosis on biopsy tissue due to the complex…

Computer Vision and Pattern Recognition · Computer Science 2019-09-17 Yongxiang Huang , Albert Chi-shing Chung

Classification of gigapixel Whole Slide Images (WSIs) is an important prediction task in the emerging area of computational pathology. There has been a surge of research in deep learning models for WSI classification with clinical…

Computer Vision and Pattern Recognition · Computer Science 2023-05-04 Sajid Javed , Arif Mahmood , Talha Qaiser , Naoufel Werghi , Nasir Rajpoot

Melanoma diagnosed and treated in its early stages can increase the survival rate. A projected increase in skin cancer incidents and a dearth of dermatopathologists have emphasized the need for computational pathology (CPATH) systems. CPATH…

Image and Video Processing · Electrical Eng. & Systems 2023-11-07 Neel Kanwal , Roger Amundsen , Helga Hardardottir , Luca Tomasetti , Erling Sandoy Undersrud , Emiel A. M. Janssen , Kjersti Engan

Whole-slide image (WSI) classification in computational pathology is commonly formulated as slide-level Multiple Instance Learning (MIL) with a single global bag representation. However, slide-level MIL is fundamentally underconstrained:…

Computer Vision and Pattern Recognition · Computer Science 2026-04-15 Syed Fahim Ahmed , Gnanesh Rasineni , Florian Koehler , Abu Zahid Bin Aziz , Mei Wang , Attila Gyulassy , Brian Summa , J. Quincy Brown , Valerio Pascucci , Shireen Y. Elhabian

Whole slide images are the foundation of digital pathology for the diagnosis and treatment of carcinomas. Writing pathology reports is laborious and error-prone for inexperienced pathologists. To reduce the workload and improve clinical…

Computer Vision and Pattern Recognition · Computer Science 2024-06-28 Pingyi Chen , Honglin Li , Chenglu Zhu , Sunyi Zheng , Zhongyi Shui , Lin Yang
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