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Workflows have been developed in the past decade to enable atom probe tomography analysis at cryogenic temperatures. The inability to control the local deposition of the metallic precursor from the gas-injection system (GIS) at cryogenic…

Materials Science · Physics 2023-06-21 James O. Douglas , Michele Conroy , Finn Giuliani , Baptiste Gault

Repeatable and reliable site-specific preparation of specimens for atom probe tomography (APT) at cryogenic temperatures has proven challenging. A generalized workflow is required for cryogenic-specimen preparation including lift-out via…

Operando/in-situ liquid cell transmission electron microscopy (LCTEM) allows for real time imaging of dynamic nanoscale liquid-based processes. However, due to the thick liquid cell of traditional LCTEM holders and thus scattering of the…

Porous microstructures, while central to many functional materials, remain difficult to characterize quantitatively by atom probe tomography (APT). Although several strategies have been proposed over the past decade, most remain constrained…

Instrumentation and Detectors · Physics 2025-10-28 Lukas Worch , James O. Douglas , Kavin Arunasalam , Baptiste Gault , Valeria Nicolosi , Michele Shelly Conroy

Imaging of liquids and cryogenic biological materials by electron microscopy has been recently enabled by innovative approaches for specimen preparation and the fast development of optimised instruments for cryo-enabled electron microscopy…

The Scanning Quantum Cryogenic Atom Microscope (SQCRAMscope) is a quantum sensor in which a quasi-1D quantum gas images electromagnetic fields emitted from a nearby sample. We report improvements to the microscope. Cryogen usage is reduced…

Atomic Physics · Physics 2021-03-10 Stephen F. Taylor , Fan Yang , Brandon A. Freudenstein , Benjamin L. Lev

Laser flash melting and revitrification experiments have recently improved the time resolution of cryo-electron microscopy (cryo-EM) to the microsecond timescale, making it fast enough to observe many of the protein motions that are…

Instrumentation and Detectors · Physics 2026-05-19 Wyatt A. Curtis , Constantin R. Krüger , Axel P. Tracol Gavard , Jakub Wenz , Marcel Drabbels , Ulrich J. Lorenz

We present sample transfer instrumentation and integrated protocols for the preparation and correlative characterization of environmentally-sensitive materials by both atom probe tomography and electron microscopy. Ultra-high vacuum…

Transmission electron microscopy has undergone a revolution in recent years with the possibility to perform routine cryo-imaging of biological materials and (bio)chemical systems, as well as the possibility to image liquids via dedicated…

The application of atom probe tomography (APT) to frozen liquids is limited by difficulties in specimen preparation. Here, we report on the use of nanoporous Cu needles as a physical framework to hold water ice for investigation using APT.…

Microscopic imaging of local magnetic fields provides a window into the organizing principles of complex and technologically relevant condensed matter materials. However, a wide variety of intriguing strongly correlated and topologically…

Mesoscale and Nanoscale Physics · Physics 2017-04-05 Fan Yang , Alicia J. Kollár , Stephen F. Taylor , Richard W. Turner , Benjamin L. Lev

Advances in cryogenic electron microscopy have opened new avenues for probing quantum phenomena in correlated materials. This study reports the installation and performance of a new side-entry condenZero cryogenic cooling system for JEOL…

Strongly Correlated Electrons · Physics 2025-09-30 Young-Hoon Kim , Fehmi Sami Yasin , Na Yeon Kim , Max Birch , Xiuzhen Yu , Akiko Kikkawa , Yasujiro Taguchi , Jiaqiang Yan , Miaofang Chi

Atomic-resolution cryogenic scanning transmission electron microscopy (cryo-STEM) has provided a path to probing the microscopic nature of select low-temperature phases in quantum materials. Expanding cryo-STEM techniques to broadly tunable…

Applied Physics · Physics 2020-11-05 Berit H. Goodge , Elisabeth Bianco , Henny W. Zandbergen Lena F. Kourkoutis

Much of the exotic functionality of prime interest in quantum materials emerges from structural and electronic ground states that can only be accessed at cryogenic temperatures. Understanding device operation therefore requires structural…

We demonstrate a novel atom chip trapping system that allows the placement and high-resolution imaging of ultracold atoms within microns from any <100 um-thin, UHV-compatible material, while also allowing sample exchange with minimal…

Scanning electron microscopy (SEM) of nanoscale objects in their native conditions and at different temperatures are of critical importance in revealing details of their interactions with ambient environments. Currently available…

Materials Science · Physics 2023-07-19 Ahmed S. Al-Asadi , Jie Zhang , Jianbo Li , Radislav A. Potyrailo , Andrei Kolmakov

Analyzing porous (nano)materials by the atom probe tomography has been notoriously difficult. The electrostatic pressure intensifies stress at voids which results in premature failure of the specimen, and the electrostatic field…

Materials Science · Physics 2022-07-27 Se-Ho Kim , Ayman A. El-Zoka , Baptiste Gault

Atom probe tomography (APT) provides the three-dimensional composition of materials at near-atomic length scales, achieving detection limits in the range of tens of atomic parts-per-million regardless of element type. APT requires the…

Proteins typically undergo conformational dynamics on the microsecond to millisecond timescale as they perform their function, which is much faster than the time-resolution of cryo-electron microscopy and has thus prevented real-time…

Biological Physics · Physics 2021-07-07 Jonathan M. Voss , Oliver F. Harder , Pavel K. Olshin , Marcel Drabbels , Ulrich J. Lorenz

Current precision experiments with single (anti)protons to test CPT symmetry progress at a rapid pace, but are complicated by the need to cool particles to sub-thermal energies. We describe a cryogenic Penning-trap setup for $^9$Be$^+$ ions…

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