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A key question in evolution is how likely a mutant is to take over. This depends on natural selection and on stochastic fluctuations. Population spatial structure can impact mutant fixation probabilities. We introduce a model for structured…
Often in the analysis of first-order methods, assuming the existence of a quadratic growth bound (a generalization of strong convexity) facilitates much stronger convergence analysis. Hence the analysis is done twice, once for the general…
Diffusion models accomplish remarkable success in data generation tasks across various domains. However, the iterative sampling process is computationally expensive. Consistency models are proposed to learn consistency functions to map from…
Deep generative models such as diffusion and flow matching are powerful machine learning tools capable of learning and sampling from high-dimensional distributions. They are particularly useful when the training data appears to be…
We study the evolution of gene frequencies in a population living in $\mathbb{R}^d$, modelled by the spatial Lambda Fleming-Viot process with natural selection (Barton, Etheridge and Veber, 2010 and Etheridge, Veber and Yu, 2014). We…
We present a stochastic version of the mean-shift clustering algorithm. In this stochastic version a randomly chosen sequence of data points move according to partial gradient ascent steps of the objective function. Theoretical results…
We present a general theory of stochastic model reduction which is based on a normal form coordinate transform method of A.J. Roberts. This nonlinear, stochastic projection allows for the deterministic and stochastic dynamics to interact…
The notion of periodic two-scale convergence and the method of periodic unfolding are prominent and useful tools in multiscale modeling and analysis of PDEs with rapidly oscillating periodic coefficients. In this paper we are interested in…
We develop a general modelling framework for compartmental epidemiological systems structured by continuous variables which are linked to the levels of expression of compartment-specific traits. We start by formulating an individual-based…
We study the existence and stability of propagating fronts in Meinhardt's multivariable reaction-diffusion model of branching in one spatial dimension. We identify a saddle-node-infinite-period (SNIPER) bifurcation of fronts that leads to…
Motivated by the need for analysing large spatio-temporal panel data, we introduce a novel dimensionality reduction methodology for $n$-dimensional random fields observed across a number $S$ spatial locations and $T$ time periods. We call…
Diffusion models have emerged as powerful tools for generative modeling, demonstrating exceptional capability in capturing target data distributions from large datasets. However, fine-tuning these massive models for specific downstream…
The first chapter concerns monotype population models. We first study general birth and death processes and we give non-explosion and extinction criteria, moment computations and a pathwise representation. We then show how different scales…
While momentum-based accelerated variants of stochastic gradient descent (SGD) are widely used when training machine learning models, there is little theoretical understanding on the generalization error of such methods. In this work, we…
Here we show that a particular one-parameter generalization of the exponential function is suitable to unify most of the popular one-species discrete population dynamics models into a simple formula. A physical interpretation is given to…
Phylogenetics uses alignments of molecular sequence data to learn about evolutionary trees relating species. Along branches, sequence evolution is modelled using a continuous-time Markov process characterised by an instantaneous rate…
This paper introduces the Generalized Space-Time Fractional Skellam Process (GSTFSP) and the Generalized Space Fractional Skellam Process (GSFSP). We investigate their distributional properties including the probability generating function…
Modeling transformations between arbitrary data distributions is a fundamental scientific challenge, arising in applications like drug discovery and evolutionary simulation. While flow matching offers a natural framework for this task, its…
Conventional diffusion models typically relies on a fixed forward process, which implicitly defines complex marginal distributions over latent variables. This can often complicate the reverse process' task in learning generative…
We consider the long-time behavior of the mean curvature flow in heterogeneous media with periodic fibrations, modeled as an additive driving force. Under appropriate assumptions on the forcing term, we show existence of generalized…