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Regulatory affairs, which sits at the intersection of medicine and law, can benefit significantly from AI-enabled automation. Classification task is the initial step in which manufacturers position their products to regulatory authorities,…

Artificial Intelligence · Computer Science 2025-05-27 Yu Han , Aaron Ceross , Jeroen H. M. Bergmann

Mathematical reasoning and optimization are fundamental to artificial intelligence and computational problem-solving. Recent advancements in Large Language Models (LLMs) have significantly improved AI-driven mathematical reasoning, theorem…

Artificial Intelligence · Computer Science 2025-03-25 Ali Forootani

Rule-based reasoning over natural language input arises in domains where decisions must be auditable and justifiable: clinical protocols specify eligibility criteria in prose, evidence rules define admissibility through textual conditions,…

Artificial Intelligence · Computer Science 2026-01-06 Albert Sadowski , Jarosław A. Chudziak

Contemporary intelligent systems incorporate software components, including machine learning components. As they grow in complexity and data volume such machine learning systems face unique quality challenges like scalability and…

Software Engineering · Computer Science 2025-01-22 Simeon Emanuilov , Aleksandar Dimov

Developing artificial intelligence (AI) for clinical research requires a comprehensive data foundation that supports model training and rigorous evaluation. Here, we introduce TrialPanorama, a large-scale structured resource that aggregates…

Artificial Intelligence · Computer Science 2025-12-17 Zifeng Wang , Jiacheng Lin , Qiao Jin , Junyi Gao , Jathurshan Pradeepkumar , Pengcheng Jiang , Zhiyong Lu , Jimeng Sun

Large Language Models (LLMs) are increasingly deployed as reasoning systems, where reasoning paradigms - such as Chain-of-Thought (CoT) and multi-agent systems (MAS) - play a critical role, yet their relative effectiveness and cost-accuracy…

Machine Learning · Computer Science 2026-01-21 Yapeng Li , Jiakuo Yu , Zhixin Liu , Xinnan Liu , Jing Yu , Songze Li , Tonghua Su

This survey paper outlines the key developments in the field of Large Language Models (LLMs), including enhancements to their reasoning skills, adaptability to various tasks, increased computational efficiency, and the ability to make…

Computation and Language · Computer Science 2026-02-12 Asifullah Khan , Muhammad Zaeem Khan , Aleesha Zainab , Saleha Jamshed , Sadia Ahmad , Kaynat Khatib , Faria Bibi , Abdul Rehman

Over the last decade, the long-running endeavour to automate high-level processes in machine learning (ML) has risen to mainstream prominence, stimulated by advances in optimisation techniques and their impact on selecting ML…

Machine Learning · Computer Science 2022-03-30 David Jacob Kedziora , Katarzyna Musial , Bogdan Gabrys

Large Language Models (LLMs) demonstrate transformative potential, yet their reasoning remains inconsistent and unreliable. Reinforcement learning (RL)-based fine-tuning is a key mechanism for improvement, but its effectiveness is…

Machine Learning · Computer Science 2026-02-11 Pei-Chi Pan , Yingbin Liang , Sen Lin

Artificial Intelligence has emerged as a useful aid in numerous clinical applications for diagnosis and treatment decisions. Deep neural networks have shown same or better performance than clinicians in many tasks owing to the rapid…

Image and Video Processing · Electrical Eng. & Systems 2021-11-05 Zohaib Salahuddin , Henry C Woodruff , Avishek Chatterjee , Philippe Lambin

The rapid progress of Multimodal Large Language Models(MLLMs) has transformed the AI landscape. These models combine pre-trained LLMs with various modality encoders. This integration requires a systematic understanding of how different…

Computation and Language · Computer Science 2025-06-06 Jisu An , Junseok Lee , Jeoungeun Lee , Yongseok Son

Predicting cancer treatment outcomes requires models that are both accurate and interpretable, particularly in the presence of heterogeneous clinical data. While large language models (LLMs) have shown strong performance in biomedical NLP,…

Computation and Language · Computer Science 2025-10-21 Raghu Vamshi Hemadri , Geetha Krishna Guruju , Kristi Topollai , Anna Ewa Choromanska

The remarkable success of multimodal large language models (MLLMs) has driven advances in multimodal embeddings, yet existing models remain inherently discriminative, limiting their ability to benefit from reasoning-driven generation…

Machine Learning · Computer Science 2026-03-03 Zhibin Lan , Liqiang Niu , Fandong Meng , Jie Zhou , Jinsong Su

Recent advancements in artificial intelligence (AI), especially large language models (LLMs), have significantly advanced healthcare applications and demonstrated potentials in intelligent medical treatment. However, there are conspicuous…

Computation and Language · Computer Science 2025-05-26 Qinkai Yu , Mingyu Jin , Dong Shu , Chong Zhang , Lizhou Fan , Wenyue Hua , Suiyuan Zhu , Yanda Meng , Zhenting Wang , Mengnan Du , Yongfeng Zhang

The widespread use of Artificial Intelligence-based tools in the healthcare sector raises many ethical and legal problems, one of the main reasons being their black-box nature and therefore the seemingly opacity and inscrutability of their…

As a prominent direction of Artificial General Intelligence (AGI), Multimodal Large Language Models (MLLMs) have garnered increased attention from both industry and academia. Building upon pre-trained LLMs, this family of models further…

Computer Vision and Pattern Recognition · Computer Science 2024-12-10 Chaoyou Fu , Yi-Fan Zhang , Shukang Yin , Bo Li , Xinyu Fang , Sirui Zhao , Haodong Duan , Xing Sun , Ziwei Liu , Liang Wang , Caifeng Shan , Ran He

Purpose: Hard-to-interpret Black-box Machine Learning (ML) were often used for early Alzheimer's Disease (AD) detection. Methods: To interpret eXtreme Gradient Boosting (XGBoost), Random Forest (RF), and Support Vector Machine (SVM)…

Machine Learning · Computer Science 2022-11-08 Louise Bloch , Christoph M. Friedrich

The increasing complexity of clinical decision-making, alongside the rapid expansion of electronic health records (EHR), presents both opportunities and challenges for delivering data-informed care. This paper proposes a clinical decision…

Artificial Intelligence · Computer Science 2025-10-03 Leon Garza , Anantaa Kotal , Michael A. Grasso , Emre Umucu

Large Language Models (LLMs) have showcased remarkable capabilities surpassing conventional NLP challenges, creating opportunities for use in production use cases. Towards this goal, there is a notable shift to building compound AI systems,…

In healthcare, multi-organ system diseases pose unique and significant challenges as they impact multiple physiological systems concurrently, demanding complex and coordinated treatment strategies. Despite recent advancements in the AI…

Artificial Intelligence · Computer Science 2025-08-08 Daniel J. Tan , Qianyi Xu , Kay Choong See , Dilruk Perera , Mengling Feng