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Early and accurate prediction of sepsis onset remains a major challenge in intensive care, where timely detection and subsequent intervention can significantly improve patient outcomes. While machine learning models have shown promise in…

Machine Learning · Computer Science 2025-09-26 Christoph Düsing , Philipp Cimiano

The use of artificial intelligence in clinical care to improve decision support systems is increasing. This is not surprising since, by its very nature, the practice of medicine consists of making decisions based on observations from…

Quantitative Methods · Quantitative Biology 2019-05-03 Isaac Mativo , Yelena Yesha , Michael Grasso , Tim Oates , Qian Zhu

Sepsis is a life-threatening condition triggered by an extreme infection response. Our objective is to forecast sepsis patient outcomes using their medical history and treatments, while learning interpretable state representations to assess…

Machine Learning · Computer Science 2023-11-17 Anna Wong , Shu Ge , Nassim Oufattole , Adam Dejl , Megan Su , Ardavan Saeedi , Li-wei H. Lehman

Sepsis accounts for more than 50% of hospital deaths, and the associated cost ranks the highest among hospital admissions in the US. Improved understanding of disease states, severity, and clinical markers has the potential to significantly…

Quantitative Methods · Quantitative Biology 2022-10-11 Chih-Hao Fang , Vikram Ravindra , Salma Akhter , Mohammad Adibuzzaman , Paul Griffin , Shankar Subramaniam , Ananth Grama

Sepsis, a life-threatening condition triggered by the body's exaggerated response to infection, demands urgent intervention to prevent severe complications. Existing machine learning methods for managing sepsis struggle in offline…

Machine Learning · Computer Science 2024-03-13 Dipesh Tamboli , Jiayu Chen , Kiran Pranesh Jotheeswaran , Denny Yu , Vaneet Aggarwal

Diabetes has emerged as a significant global health issue, especially with the increasing number of cases in many countries. This trend Underlines the need for a greater emphasis on early detection and proactive management to avert or…

Machine Learning · Computer Science 2025-06-16 Mowafaq Salem Alzboon , Muhyeeddin Alqaraleh , Mohammad Subhi Al-Batah

Sepsis is a life-threatening condition affecting one million people per year in the US in which dysregulation of the body's own immune system causes damage to its tissues, resulting in a 28 - 50% mortality rate. Clinical trials for sepsis…

Machine Learning · Computer Science 2018-03-01 Brenden K. Petersen , Jiachen Yang , Will S. Grathwohl , Chase Cockrell , Claudio Santiago , Gary An , Daniel M. Faissol

Motivated by an observational study of the effect of hospital ward versus intensive care unit admission on severe sepsis mortality, we develop methods to address two common problems in observational studies: (1) when there is a lack of…

Applications · Statistics 2015-08-13 Colin B. Fogarty , Mark E. Mikkelsen , David F. Gaieski , Dylan S. Small

Early hospital mortality prediction is critical as intensivists strive to make efficient medical decisions about the severely ill patients staying in intensive care units. As a result, various methods have been developed to address this…

Machine Learning · Computer Science 2019-02-12 Reza Sadeghi , Tanvi Banerjee , William Romine

The choice of the most effective treatment may eventually be influenced by breast cancer survival prediction. To predict the chances of a patient surviving, a variety of techniques were employed, such as statistical, machine learning, and…

Machine Learning · Computer Science 2023-04-18 Khaoula Chtouki , Maryem Rhanoui , Mounia Mikram , Kamelia Amazian , Siham Yousfi

Background: Elderly patients with MODS have high risk of death and poor prognosis. The performance of current scoring systems assessing the severity of MODS and its mortality remains unsatisfactory. This study aims to develop an…

Sepsis is a life-threatening infectious syndrome associated with high mortality in intensive care units (ICUs). Early and accurate sepsis prediction (SP) is critical for timely intervention, yet remains challenging due to subtle early…

Machine Learning · Computer Science 2025-10-22 Zexi Tan , Tao Xie , Binbin Sun , Xiang Zhang , Yiqun Zhang , Yiu-Ming Cheung

The intensive care unit (ICU) comprises a complex hospital environment, where decisions made by clinicians have a high level of risk for the patients' lives. A comprehensive care pathway must then be followed to reduce p complications.…

Acute myocardial infarction (AMI) is one of the most severe manifestation of coronary artery disease. ST-segment elevation myocardial infarction (STEMI) is the most serious type of AMI. We proposed to develop a machine learning algorithm…

Quantitative Methods · Quantitative Biology 2022-11-29 Ding Tao , Chen Liu , Shihan Wan

Objective: Sepsis is a life-threatening condition caused by severe infection leading to acute organ dysfunction. This study proposes a data-driven metric and a continuous reward function to optimize personalized heparin therapy in surgical…

Machine Learning · Computer Science 2025-12-15 Jiang Liu , Yujie Li , Chan Zhou , Yihao Xie , Qilong Sun , Xin Shu , Peiwei Li , Chunyong Yang , Yiziting Zhu , Jiaqi Zhu , Yuwen Chen , Bo An , Hao Wu , Bin Yi

Sepsis is a condition caused by the body's overwhelming and life-threatening response to infection, which can lead to tissue damage, organ failure, and finally death. Common signs and symptoms include fever, increased heart rate, increased…

Machine Learning · Computer Science 2017-09-07 Eitam Sheetrit , Nir Nissim , Denis Klimov , Lior Fuchs , Yuval Elovici , Yuval Shahar

The disease trajectory for clinical sepsis, in terms of temporal cytokine and phenotypic dynamics, can be interpreted as a random dynamical system. The ability to make accurate predictions about patient state from clinical measurements has…

Quantitative Methods · Quantitative Biology 2020-07-30 Dale Larie , Gary An , Chase Cockrell

Sepsis is a life-threatening host response to infection associated with high mortality, morbidity, and health costs. Its management is highly time-sensitive since each hour of delayed treatment increases mortality due to irreversible organ…

Machine Learning · Computer Science 2020-10-16 Michael Moor , Max Horn , Bastian Rieck , Damian Roqueiro , Karsten Borgwardt

Mortality prediction in intensive care units is considered one of the critical steps for efficiently treating patients in serious condition. As a result, various prediction models have been developed to address this problem based on modern…

Machine Learning · Computer Science 2020-12-15 Huachuan Wang , Yuanfei Bi

An estimated 300 million people worldwide suffer from asthma, and this number is expected to increase to 400 million by 2025. Approximately 250,000 people die prematurely each year from asthma out of which, almost all deaths are avoidable.…

Computers and Society · Computer Science 2018-04-13 Saksham Kukreja
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