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To achieve high-quality results, diffusion models must be trained on large datasets. This can be notably prohibitive for models in specialized domains, such as computational pathology. Conditioning on labeled data is known to help in…

Computer Vision and Pattern Recognition · Computer Science 2023-12-04 Srikar Yellapragada , Alexandros Graikos , Prateek Prasanna , Tahsin Kurc , Joel Saltz , Dimitris Samaras

Low-rank Adaptation (LoRA) models have revolutionized the personalization of pre-trained diffusion models by enabling fine-tuning through low-rank, factorized weight matrices specifically optimized for attention layers. These models…

Computer Vision and Pattern Recognition · Computer Science 2025-12-18 Mert Sonmezer , Matthew Zheng , Pinar Yanardag

Generative models are increasingly used to augment medical imaging datasets for fairer AI. Yet a key assumption often goes unexamined: that generators themselves produce equally high-quality images across demographic groups. Models trained…

Computer Vision and Pattern Recognition · Computer Science 2026-03-18 Mahmoud Ibrahim , Bart Elen , Chang Sun , Gokhan Ertaylan , Michel Dumontier

In recent years, trace generation has emerged as a significant challenge within the Process Mining community. Deep Learning (DL) models have demonstrated accuracy in reproducing the features of the selected processes. However, current DL…

Computationally generating novel synthetically accessible compounds with high affinity and low toxicity is a great challenge in drug design. Machine-learning models beyond conventional pharmacophoric methods have shown promise in generating…

Biomolecules · Quantitative Biology 2023-10-30 Nicholas T. Runcie , Antonia S. J. S. Mey

In addressing the computational and memory demands of fine-tuning Large Language Models(LLMs), we propose LoRA-SP(Streamlined Partial Parameter Adaptation), a novel approach utilizing randomized half-selective parameter freezing within the…

Machine Learning · Computer Science 2024-03-15 Yichao Wu , Yafei Xiang , Shuning Huo , Yulu Gong , Penghao Liang

High Dynamic Range (HDR) images can be recovered from several Low Dynamic Range (LDR) images by existing Deep Neural Networks (DNNs) techniques. Despite the remarkable progress, DNN-based methods still generate ghosting artifacts when LDR…

Computer Vision and Pattern Recognition · Computer Science 2023-11-03 Qingsen Yan , Tao Hu , Yuan Sun , Hao Tang , Yu Zhu , Wei Dong , Luc Van Gool , Yanning Zhang

Probabilistic diffusion models have achieved state-of-the-art results for image synthesis, inpainting, and text-to-image tasks. However, they are still in the early stages of generating complex 3D shapes. This work proposes Diffusion-SDF, a…

Computer Vision and Pattern Recognition · Computer Science 2023-03-17 Gene Chou , Yuval Bahat , Felix Heide

The structure of topology underpins much of the research on performance and robustness, yet available topology data are typically scarce, necessitating the generation of synthetic graphs with desired properties for testing or release. Prior…

Machine Learning · Computer Science 2025-12-24 Gongli Xi , Ye Tian , Mengyu Yang , Zhenyu Zhao , Yuchao Zhang , Xiangyang Gong , Xirong Que , Wendong Wang

Diffusion models have recently been shown to be relevant for high-quality speech generation. Most work has been focused on generating spectrograms, and as such, they further require a subsequent model to convert the spectrogram to a…

Sound · Computer Science 2024-03-12 Roi Benita , Michael Elad , Joseph Keshet

Deep generative models are proficient in generating realistic data but struggle with producing rare samples in low density regions due to their scarcity of training datasets and the mode collapse problem. While recent methods aim to improve…

Computer Vision and Pattern Recognition · Computer Science 2025-01-08 Subeen Lee , Jiyeon Han , Soyeon Kim , Jaesik Choi

Many protein design applications, such as binder or enzyme design, require scaffolding a structural motif with high precision. Generative modelling paradigms based on denoising diffusion processes emerged as a leading candidate to address…

Machine Learning · Computer Science 2024-03-15 Kieran Didi , Francisco Vargas , Simon V Mathis , Vincent Dutordoir , Emile Mathieu , Urszula J Komorowska , Pietro Lio

We develop a new framework for learning variational autoencoders and other deep generative models that balances generative and discriminative goals. Our framework optimizes model parameters to maximize a variational lower bound on the…

Machine Learning · Computer Science 2020-12-15 Gabriel Hope , Madina Abdrakhmanova , Xiaoyin Chen , Michael C. Hughes , Michael C. Hughes , Erik B. Sudderth

This paper introduces an approach to endow generative diffusion processes the ability to satisfy and certify compliance with constraints and physical principles. The proposed method recast the traditional sampling process of generative…

Machine Learning · Computer Science 2024-11-05 Jacob K Christopher , Stephen Baek , Ferdinando Fioretto

Novel diffusion models can synthesize photo-realistic images with integrated high-quality text. Surprisingly, we demonstrate through attention activation patching that only less than $1$% of diffusion models' parameters, all contained in…

Computer Vision and Pattern Recognition · Computer Science 2026-03-03 Łukasz Staniszewski , Bartosz Cywiński , Franziska Boenisch , Kamil Deja , Adam Dziedzic

Partial-differential-equation (PDE)-constrained optimization is a well-worn technique for acquiring optimal parameters of systems governed by PDEs. However, this approach is limited to providing a single set of optimal parameters per…

Computational Physics · Physics 2024-10-17 Archis S. Joglekar

Customization generation techniques have significantly advanced the synthesis of specific concepts across varied contexts. Multi-concept customization emerges as the challenging task within this domain. Existing approaches often rely on…

Computer Vision and Pattern Recognition · Computer Science 2024-07-12 Yang Yang , Wen Wang , Liang Peng , Chaotian Song , Yao Chen , Hengjia Li , Xiaolong Yang , Qinglin Lu , Deng Cai , Boxi Wu , Wei Liu

We introduce a novel resampling criterion using lift scores, for improving compositional generation in diffusion models. By leveraging the lift scores, we evaluate whether generated samples align with each single condition and then compose…

Machine Learning · Computer Science 2025-05-27 Chenning Yu , Sicun Gao

Automatically generating high-quality real world 3D scenes is of enormous interest for applications such as virtual reality and robotics simulation. Towards this goal, we introduce NeuralField-LDM, a generative model capable of synthesizing…

Computer Vision and Pattern Recognition · Computer Science 2023-04-20 Seung Wook Kim , Bradley Brown , Kangxue Yin , Karsten Kreis , Katja Schwarz , Daiqing Li , Robin Rombach , Antonio Torralba , Sanja Fidler

We develop a class of data-driven generative models that approximate the solution operator for parameter-dependent partial differential equations (PDE). We propose a novel probabilistic formulation of the operator learning problem based on…

Numerical Analysis · Mathematics 2026-04-21 Ting Wang , Petr Plechac , Jaroslaw Knap