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Deep brain stimulation (DBS) is an established intervention for Parkinson's disease (PD), but conventional open-loop systems lack adaptability, are energy-inefficient due to continuous stimulation, and provide limited personalization to…
Adaptive deep brain stimulation (aDBS) has emerged as a promising treatment for Parkinson disease (PD). In aDBS, a surgically placed electrode sends dynamically altered stimuli to the brain based on neurophysiological feedback: an invasive…
We present a nonlinear data-driven Model Predictive Control (MPC) algorithm for deep brain stimulation (DBS) for the treatment of Parkinson's disease (PD). Although DBS is typically implemented in open-loop, closed-loop DBS (CLDBS) uses the…
Deep brain stimulation (DBS) is an advanced surgical treatment for the symptoms of Parkinson's disease (PD), involving electrical stimulation of neurons within the basal ganglia region of the brain. DBS is traditionally delivered in an…
Deep brain stimulation (DBS) has shown great promise toward treating motor symptoms caused by Parkinson's disease (PD), by delivering electrical pulses to the Basal Ganglia (BG) region of the brain. However, DBS devices approved by the U.S.…
Closed-loop brain stimulation refers to capturing neurophysiological measures such as electroencephalography (EEG), quickly identifying neural events of interest, and producing auditory, magnetic or electrical stimulation so as to interact…
Non-invasive Brain-Computer Interfaces (BCI) offer a safe and accessible means of connecting the human brain to external devices, with broad applications in home and clinical settings to enhance human capabilities. However, the high noise…
Deep Brain Stimulation (DBS) stands as an effective intervention for alleviating the motor symptoms of Parkinson's disease (PD). Traditional commercial DBS devices are only able to deliver fixed-frequency periodic pulses to the basal…
Objective: Closed-loop deep brain stimulation (DBS) may improve current clinical DBS treatment for neurological movement disorders, but control algorithms may perform differently across patients. New metrics are needed for comparing and…
BabelBrain is an open-source standalone graphic-user-interface application designed for studies of neuromodulation using transcranial focused ultrasound. It calculates the transmitted acoustic field in the brain tissue, taking into account…
Parkinson's Disease afflicts millions of individuals globally. Emerging as a promising brain rehabilitation therapy for Parkinson's Disease, Closed-loop Deep Brain Stimulation (CL-DBS) aims to alleviate motor symptoms. The CL-DBS system…
Model-based design of experiments (MBDOE) is essential for efficient parameter estimation in nonlinear dynamical systems. However, conventional adaptive MBDOE requires costly posterior inference and design optimization between each…
Closed-loop brain stimulation holds potential as personalized treatment for drug-resistant epilepsy (DRE) but still suffers from limitations that result in highly variable efficacy. First, stimulation is typically delivered upon detection…
Epilepsy is the fourth most common neurological disorder and affects people of all ages worldwide. Deep Brain Stimulation (DBS) has emerged as an alternative treatment option when anti-epileptic drugs or resective surgery cannot lead to…
Deep Brain Stimulation (DBS) is an effective treatment for Parkinson's disease, but conventional fixed-parameter stimulation can reduce battery life and cause side effects while failing to adapt to changing neural dynamics. Recent…
Adaptive deep brain stimulation (aDBS) leverages symptom-related biomarkers to deliver personalized neuromodulation therapy, with the potential to improve treatment efficacy and reduce power consumption compared to conventional DBS.…
In this work, we present a computing platform named digital twin brain (DTB) that can simulate spiking neuronal networks of the whole human brain scale and more importantly, a personalized biological brain structure. In comparison to most…
Neural-networks-driven intelligent data-plane (NN-driven IDP) is becoming an emerging topic for excellent accuracy and high performance. Meanwhile we argue that NN-driven IDP should satisfy three design goals: the flexibility to support…
Inspire therapy is an FDA-approved internal neurostimulation treatment for obstructive sleep apnea. However, not all patients respond to this therapy, posing a challenge even for experienced otolaryngologists to determine candidacy. This…
Deep brain stimulation (DBS) can alleviate the movement disorders like Parkinson's disease (PD). Indeed, it is known that aberrant beta (13-30Hz)oscillations and the loss of dopaminergic neurons in the basal ganglia-thalamus (BGTH) and…