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Large language models (LLMs) can simulate clinical reasoning based on natural language prompts, but their utility in ophthalmology is largely unexplored. This study evaluated GPT-4's ability to interpret structured textual descriptions of…

Computation and Language · Computer Science 2025-07-03 Cindy Lie Tabuse , David Restepo , Carolina Gracitelli , Fernando Korn Malerbi , Caio Regatieri , Luis Filipe Nakayama

This study examines the effect of prompt engineering on the performance of Large Language Models (LLMs) in clinical note generation. We introduce an Automatic Prompt Optimization (APO) framework to refine initial prompts and compare the…

Computation and Language · Computer Science 2024-07-08 Zonghai Yao , Ahmed Jaafar , Beining Wang , Zhichao Yang , Hong Yu

The rapid expansion of electronic health record (EHR) systems has generated large volumes of unstructured clinical narratives that contain valuable information for disease identification, patient cohort discovery, and clinical decision…

Computation and Language · Computer Science 2026-03-17 Fariba Afrin Irany , Sampson Akwafuo

Artificial intelligence (AI) has transformed medical imaging, with computer vision (CV) systems achieving state-of-the-art performance in classification and detection tasks. However, these systems typically output structured predictions,…

Computer Vision and Pattern Recognition · Computer Science 2026-01-01 Trishna Niraula , Jonathan Stubblefield

Automatic text summarization (ATS) is an emerging technology to assist clinicians in providing continuous and coordinated care. This study presents an approach to summarize doctor-patient dialogues using generative large language models…

Computation and Language · Computer Science 2024-03-21 Mengxian Lyu , Cheng Peng , Xiaohan Li , Patrick Balian , Jiang Bian , Yonghui Wu

This paper explores using GPT-3.5 and GPT-4 to automate the data annotation process with automatic prompting techniques. The main aim of this paper is to reuse human annotation guidelines along with some annotated data to design automatic…

Computation and Language · Computer Science 2024-07-08 Sachin Yadav , Tejaswi Choppa , Dominik Schlechtweg

The field of healthcare has increasingly turned its focus towards Large Language Models (LLMs) due to their remarkable performance. However, their performance in actual clinical applications has been underexplored. Traditional evaluations…

Recent studies have demonstrated promising performance of ChatGPT and GPT-4 on several medical domain tasks. However, none have assessed its performance using a large-scale real-world electronic health record database, nor have evaluated…

Computation and Language · Computer Science 2023-07-18 Jingqing Zhang , Kai Sun , Akshay Jagadeesh , Mahta Ghahfarokhi , Deepa Gupta , Ashok Gupta , Vibhor Gupta , Yike Guo

The increasing availability of unstructured clinical narratives in electronic health records (EHRs) has created new opportunities for automated disease characterization, cohort identification, and clinical decision support. However,…

Computation and Language · Computer Science 2026-03-03 Fariba Afrin Irany , Sampson Akwafuo

The rapid development of language-based artificial intelligence (AI) offers new possibilities for psychotherapy and assistive systems, particularly benefitting autistic individuals who often respond well to technology. Parents of autistic…

Background: The potential of large language models (LLMs) to automate and support pharmacoepidemiologic study design is an emerging area of interest, yet their reliability remains insufficiently characterized. General-purpose LLMs often…

Computation and Language · Computer Science 2026-04-21 Xinyao Zhang , Nicole Sonne Heckmann , Manuela Del Castillo Suero , Francesco Paolo Speca , Maurizio Sessa

Large Language Models (LLMs), typified by OpenAI's GPT, have marked a significant advancement in artificial intelligence. Trained on vast amounts of text data, LLMs are capable of understanding and generating human-like text across a…

Artificial Intelligence · Computer Science 2024-10-29 Haochen Zhang , Yuyang Dong , Chuan Xiao , Masafumi Oyamada

Biomedical text summarization is a critical tool that enables clinicians to effectively ascertain patient status. Traditionally, text summarization has been accomplished with transformer models, which are capable of compressing long…

Computation and Language · Computer Science 2024-04-16 Hyunkyung Han , Jaesik Choi

Automated text annotation is a compelling use case for generative large language models (LLMs) in social media research. Recent work suggests that LLMs can achieve strong performance on annotation tasks; however, these studies evaluate LLMs…

Computation and Language · Computer Science 2024-09-24 Nicholas Pangakis , Samuel Wolken

In practice, clinicians achieve a diagnosis by following a sequence of steps, such as laboratory exams, observations, or imaging. The pathways to reach diagnosis decisions are documented by guidelines authored by expert organizations, which…

Computation and Language · Computer Science 2024-09-25 Elisa Castagnari , Lillian Muyama , Adrien Coulet

The rapid evolution of LLMs represents an impactful paradigm shift in digital interaction and content engagement. While they encode vast amounts of human-generated knowledge and excel in processing diverse data types, they often face the…

Human-Computer Interaction · Computer Science 2024-11-20 Anna Bodonhelyi , Efe Bozkir , Shuo Yang , Enkelejda Kasneci , Gjergji Kasneci

This study aims to explore the performance improvement method of large language models based on GPT-4 under the multi-task learning framework and conducts experiments on two tasks: text classification and automatic summary generation.…

Computation and Language · Computer Science 2024-12-10 Zhen Qi , Jiajing Chen , Shuo Wang , Bingying Liu , Hongye Zheng , Chihang Wang

Multimodal large language models (MLLMs) represent an evolutionary expansion in the capabilities of traditional large language models, enabling them to tackle challenges that surpass the scope of purely text-based applications. It leverages…

Computation and Language · Computer Science 2025-01-17 Jinlong He , Pengfei Li , Gang Liu , Genrong He , Zhaolin Chen , Shenjun Zhong

Patients often face difficulties in understanding their hospitalizations, while healthcare workers have limited resources to provide explanations. In this work, we investigate the potential of large language models to generate patient…

Computation and Language · Computer Science 2024-06-26 Stefan Hegselmann , Shannon Zejiang Shen , Florian Gierse , Monica Agrawal , David Sontag , Xiaoyi Jiang

This study evaluates the ability of large language models (LLMs) to map biomedical ontology terms to their corresponding ontology IDs across the Human Phenotype Ontology (HPO), Gene Ontology (GO), and UniProtKB terminologies. Using counts…

Computation and Language · Computer Science 2025-05-13 Thanh Son Do , Daniel B. Hier , Tayo Obafemi-Ajayi