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Intracranial carotid artery calcification (ICAC) is a major risk factor for stroke, and might contribute to dementia and cognitive decline. Reliance on time-consuming manual annotation of ICAC hampers much demanded further research into the…

Computer Vision and Pattern Recognition · Computer Science 2017-06-06 Gerda Bortsova , Gijs van Tulder , Florian Dubost , Tingying Peng , Nassir Navab , Aad van der Lugt , Daniel Bos , Marleen de Bruijne

Purpose: To evaluate a fully-automated deep-learning-based method for assessment of intracranial carotid artery calcification (ICAC). Methods: Two observers manually delineated ICAC in non-contrast CT scans of 2,319 participants (mean age…

Image and Video Processing · Electrical Eng. & Systems 2021-07-21 Gerda Bortsova , Daniel Bos , Florian Dubost , Meike W. Vernooij , M. Kamran Ikram , Gijs van Tulder , Marleen de Bruijne

Coronary artery calcification (CAC) is a strong predictor of cardiovascular risk but remains underutilized in clinical routine thoracic imaging due to the need for dedicated imaging protocols and manual annotation. We present DeepCAC2, a…

Image and Video Processing · Electrical Eng. & Systems 2026-03-27 Leonard Nürnberg , Simon Bernatz , Borek Foldyna , Michael T. Lu , Andrey Fedorov , Hugo JWL Aerts

Timely diagnosis of Intracranial hemorrhage (ICH) on Computed Tomography (CT) scans remains a clinical priority, yet the development of robust Artificial Intelligence (AI) solutions is still hindered by fragmented public data. To close this…

Computer Vision and Pattern Recognition · Computer Science 2025-11-07 Kasra Davoodi , Mohammad Hoseyni , Javad Khoramdel , Reza Barati , Reihaneh Mortazavi , Amirhossein Nikoofard , Mahdi Aliyari-Shoorehdeli , Jaber Hatam Parikhan

Purpose: Coronary artery calcium (CAC) score, i.e. the amount of CAC quantified in CT, is a strong and independent predictor of coronary heart disease (CHD) events. However, CAC scoring suffers from limited interscan reproducibility, which…

Image and Video Processing · Electrical Eng. & Systems 2022-06-13 Sanne G. M. van Velzen , Bob D. de Vos , Julia M. H. Noothout , Helena M. Verkooijen , Max A. Viergever , Ivana Išgum

Vascular calcification is implicated as an important factor in major adverse cardiovascular events (MACE), including heart attack and stroke. A controversy remains over how to integrate the diverse forms of vascular calcification into…

Computer Vision and Pattern Recognition · Computer Science 2024-01-18 Mehdi Ramezanpour , Anne M. Robertson , Yasutaka Tobe , Xiaowei Jia , Juan R. Cebral

We propose Artificial Intelligence Prospective Randomized Observer Blinding Evaluation (AI-PROBE) for quantitative clinical performance evaluation of radiology AI systems within prospective randomized clinical trials. AI-PROBE encompasses a…

Medical Physics · Physics 2020-03-02 Axel Wismüller , Larry Stockmaster

While total intracranial carotid artery calcification (ICAC) volume is an established stroke biomarker, growing evidence shows this aggregate metric ignores the critical influence of plaque location, since calcification in different…

Image and Video Processing · Electrical Eng. & Systems 2025-10-07 Xiangjian Hou , Ebru Yaman Akcicek , Xin Wang , Kazem Hashemizadeh , Scott Mcnally , Chun Yuan , Xiaodong Ma

Enhancing the precision of segmenting coronary atherosclerotic plaques from CT Angiography (CTA) images is pivotal for advanced Coronary Atherosclerosis Analysis (CAA), which distinctively relies on the analysis of vessel cross-section…

Image and Video Processing · Electrical Eng. & Systems 2025-01-15 Ziheng Zhang , Zihan Li , Dandan Shan , Yuehui Qiu , Qingqi Hong , Qingqiang Wu

Coronary artery calcium (CAC) is highly predictive of cardiovascular events. While millions of chest CT scans are performed annually in the United States, CAC is not routinely quantified from scans done for non-cardiac purposes. A deep…

Coronary artery calcium (CAC) scoring plays a crucial role in the early detection and risk stratification of coronary artery disease (CAD). In this study, we focus on non-contrast coronary computed tomography angiography (CCTA) scans, which…

The standard non-invasive imaging technique used to assess the severity and extent of Coronary Artery Disease (CAD) is Coronary Computed Tomography Angiography (CCTA). However, manual grading of each patient's CCTA according to the…

Stroke is among the top three causes of death worldwide, and accurate identification of ischemic stroke lesion boundaries from imaging is critical for diagnosis and treatment. The main imaging modalities used include magnetic resonance…

Image and Video Processing · Electrical Eng. & Systems 2025-08-25 Juampablo E. Heras Rivera , Hitender Oswal , Tianyi Ren , Yutong Pan , William Henry , Caitlin M. Neher , Mehmet Kurt

Coronary artery calcium (CAC) is a significant marker of atherosclerosis and cardiovascular events. In this work we present a system for the automatic quantification of calcium score in ECG-triggered non-contrast enhanced cardiac computed…

Computer Vision and Pattern Recognition · Computer Science 2017-10-10 G. Santini , D. Della Latta , N. Martini , G. Valvano , A. Gori , A. Ripoli , C. L. Susini , L. Landini , D. Chiappino

Cardiovascular disease causes high rates of mortality worldwide. Coronary artery calcium (CAC) scoring is a powerful tool to stratify the risk of atherosclerotic cardiovascular disease. Current scoring practices require time-intensive…

Computer Vision and Pattern Recognition · Computer Science 2025-11-12 Lachlan Nguyen , Aidan Cousins , Arcot Sowmya , Hugh Dixson , Sonit Singh

Automatic intracranial hemorrhage segmentation in 3D non-contrast head CT (NCCT) scans is significant in clinical practice. Existing hemorrhage segmentation methods usually ignores the anisotropic nature of the NCCT, and are evaluated on…

Computed Tomography (CT) is commonly used to image acute ischemic stroke (AIS) patients, but its interpretation by radiologists is time-consuming and subject to inter-observer variability. Deep learning (DL) techniques can provide automated…

Image and Video Processing · Electrical Eng. & Systems 2023-10-02 Alessandro Fontanella , Wenwen Li , Grant Mair , Antreas Antoniou , Eleanor Platt , Paul Armitage , Emanuele Trucco , Joanna Wardlaw , Amos Storkey

Automatically labeling intracranial arteries (ICA) with their anatomical names is beneficial for feature extraction and detailed analysis of intracranial vascular structures. There are significant variations in the ICA due to natural and…

Computer Vision and Pattern Recognition · Computer Science 2020-07-30 Li Chen , Thomas Hatsukami , Jenq-Neng Hwang , Chun Yuan

More than 13 million people suffer from ischemic cerebral stroke worldwide each year. Thrombolytic treatment can reduce brain damage but has a narrow treatment window. Computed Tomography Perfusion imaging is a commonly used primary…

Image and Video Processing · Electrical Eng. & Systems 2021-04-22 Luca Tomasetti , Kjersti Engan , Mahdieh Khanmohammadi , Kathinka Dæhli Kurz

Purpose: Multi-expert deep learning training methods to automatically quantify ischemic brain tissue on Non-Contrast CT Materials and Methods: The data set consisted of 260 Non-Contrast CTs from 233 patients of acute ischemic stroke…

Computer Vision and Pattern Recognition · Computer Science 2024-03-26 Sophie Ostmeier , Brian Axelrod , Benjamin Pulli , Benjamin F. J. Verhaaren , Abdelkader Mahammedi , Yongkai Liu , Christian Federau , Greg Zaharchuk , Jeremy J. Heit
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