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Latent variable models such as the Variational Auto-Encoder (VAE) have become a go-to tool for analyzing biological data, especially in the field of single-cell genomics. One remaining challenge is the interpretability of latent variables…

Genomics · Quantitative Biology 2023-02-20 Romain Lopez , Nataša Tagasovska , Stephen Ra , Kyunghyn Cho , Jonathan K. Pritchard , Aviv Regev

Given an image dataset, we are often interested in finding data generative factors that encode semantic content independently from pose variables such as rotation and translation. However, current disentanglement approaches do not impose…

Computer Vision and Pattern Recognition · Computer Science 2019-09-27 Tristan Bepler , Ellen D. Zhong , Kotaro Kelley , Edward Brignole , Bonnie Berger

Generative modeling aims to generate new data samples that resemble a given dataset, with diffusion models recently becoming the most popular generative model. One of the main challenges of diffusion models is solving the problem in the…

Numerical Analysis · Mathematics 2025-10-08 Wonjun Lee , Riley C. W. O'Neill , Dongmian Zou , Jeff Calder , Gilad Lerman

Representation learning seeks to expose certain aspects of observed data in a learned representation that's amenable to downstream tasks like classification. For instance, a good representation for 2D images might be one that describes only…

Machine Learning · Computer Science 2017-03-07 Xi Chen , Diederik P. Kingma , Tim Salimans , Yan Duan , Prafulla Dhariwal , John Schulman , Ilya Sutskever , Pieter Abbeel

We propose a cross-domain latent modulation mechanism within a variational autoencoders (VAE) framework to enable improved transfer learning. Our key idea is to procure deep representations from one data domain and use it as perturbation to…

Machine Learning · Computer Science 2020-12-23 Jinyong Hou , Jeremiah D. Deng , Stephen Cranefield , Xuejie Ding

Unsupervised representation learning via generative modeling is a staple to many computer vision applications in the absence of labeled data. Variational Autoencoders (VAEs) are powerful generative models that learn representations useful…

Machine Learning · Computer Science 2020-03-24 Riddhish Bhalodia , Iain Lee , Shireen Elhabian

Multivariate time series with missing values are common in areas such as healthcare and finance, and have grown in number and complexity over the years. This raises the question whether deep learning methodologies can outperform classical…

Machine Learning · Statistics 2020-02-21 Vincent Fortuin , Dmitry Baranchuk , Gunnar Rätsch , Stephan Mandt

High-throughput phenotypic screens generate vast microscopy image datasets that push the limits of generative models due to their large dimensionality. Despite the growing popularity of general-purpose models trained on natural images for…

Quantitative Methods · Quantitative Biology 2025-10-24 Télio Cropsal , Rocío Mercado

The variational autoencoder (VAE) is a simple and efficient generative artificial intelligence method for modeling complex probability distributions of various types of data, such as images and texts. However, it suffers some main…

Machine Learning · Computer Science 2025-02-14 Xi Chen , Shaofan Li

Diffusion Probabilistic Models (DPMs) have shown a powerful capacity of generating high-quality image samples. Recently, diffusion autoencoders (Diff-AE) have been proposed to explore DPMs for representation learning via autoencoding. Their…

Computer Vision and Pattern Recognition · Computer Science 2023-03-02 Zijian Zhang , Zhou Zhao , Zhijie Lin

Neural samplers such as variational autoencoders (VAEs) or generative adversarial networks (GANs) approximate distributions by transforming samples from a simple random source---the latent space---to samples from a more complex distribution…

Machine Learning · Statistics 2018-02-09 Nutan Chen , Alexej Klushyn , Richard Kurle , Xueyan Jiang , Justin Bayer , Patrick van der Smagt

The ability to accurately model random fields plays a critical role in science and engineering for problems involving uncertain, spatially-varying quantities such as heterogeneous material properties and turbulent flows. Deep generative…

Diffusion probabilistic models (DPMs) have shown remarkable results on various image synthesis tasks such as text-to-image generation and image inpainting. However, compared to other generative methods like VAEs and GANs, DPMs lack a…

Computer Vision and Pattern Recognition · Computer Science 2023-07-13 Yipeng Leng , Qiangjuan Huang , Zhiyuan Wang , Yangyang Liu , Haoyu Zhang

While mel-spectrograms have been widely utilized as intermediate representations in zero-shot text-to-speech (TTS), their inherent redundancy leads to inefficiency in learning text-speech alignment. Compact VAE-based latent representations…

Audio and Speech Processing · Electrical Eng. & Systems 2025-12-02 Zhikang Niu , Shujie Hu , Jeongsoo Choi , Yushen Chen , Peining Chen , Pengcheng Zhu , Yunting Yang , Bowen Zhang , Jian Zhao , Chunhui Wang , Xie Chen

The continuous representation of spatiotemporal data commonly relies on using abstract data types, such as \textit{moving regions}, to represent entities whose shape and position continuously change over time. Creating this representation…

Databases · Computer Science 2023-08-29 Tiago F. R. Ribeiro , Fernando Silva , Rogério Luís de C. Costa

Recent advances in generative AI offer promising solutions for synthetic data generation but often rely on large datasets for effective training. To address this limitation, we propose a novel generative model that learns from limited data…

Machine Learning · Statistics 2025-05-27 Michail Spitieris , Massimiliano Ruocco , Abdulmajid Murad , Alessandro Nocente

In generative modeling, numerous successful approaches leverage a low-dimensional latent space, e.g., Stable Diffusion models the latent space induced by an encoder and generates images through a paired decoder. Although the selection of…

Machine Learning · Computer Science 2023-10-31 Tianyang Hu , Fei Chen , Haonan Wang , Jiawei Li , Wenjia Wang , Jiacheng Sun , Zhenguo Li

Given a dataset of images containing different objects with different features such as shape, size, rotation, and x-y position; and a Variational Autoencoder (VAE); creating a disentangled encoding of these features in the hidden space…

Computer Vision and Pattern Recognition · Computer Science 2022-08-10 Mohammad Haghir Ebrahimabadi

As a widely recognized approach to deep generative modeling, Variational Auto-Encoders (VAEs) still face challenges with the quality of generated images, often presenting noticeable blurriness. This issue stems from the unrealistic…

Machine Learning · Computer Science 2023-05-22 Georgios Batzolis , Jan Stanczuk , Carola-Bibiane Schönlieb

Learning disentangled representations of real-world data is a challenging open problem. Most previous methods have focused on either supervised approaches which use attribute labels or unsupervised approaches that manipulate the…

Computation and Language · Computer Science 2021-01-26 Vikash Balasubramanian , Ivan Kobyzev , Hareesh Bahuleyan , Ilya Shapiro , Olga Vechtomova
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