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Accurate prediction of protein-ligand binding affinity remains a central challenge in structure-based drug discovery. The effectiveness of machine learning models critically depends on the quality of molecular descriptors, for which…

Biomolecules · Quantitative Biology 2026-03-24 Jian Liu , Hongsong Feng

Topological data analysis (TDA) is a rapidly evolving field in applied mathematics and data science that leverages tools from topology to uncover robust, shape-driven insights in complex datasets. The main workhorse is persistent homology,…

History and Overview · Mathematics 2025-07-29 Zhe Su , Xiang Liu , Layal Bou Hamdan , Vasileios Maroulas , Jie Wu , Gunnar Carlsson , Guo-Wei Wei

Persistent topological Laplacians constitute a new class of tools in topological data analysis (TDA). They are motivated by the necessity to address challenges encountered in persistent homology when handling complex data. These Laplacians…

Algebraic Topology · Mathematics 2024-12-12 Xiaoqi Wei , Guo-Wei Wei

A suitable feature representation that can both preserve the data intrinsic information and reduce data complexity and dimensionality is key to the performance of machine learning models. Deeply rooted in algebraic topology, persistent…

Algebraic Topology · Mathematics 2018-11-02 Chi Seng Pun , Kelin Xia , Si Xian Lee

While topological data analysis has emerged as a powerful paradigm for structural inference, its foundational tools, notably persistent homology and the persistent Laplacian, are frequently insensitive to localized structural fluctuations…

Algebraic Topology · Mathematics 2026-03-10 Jian Liu , Hongsong Feng , Kefeng Liu

Recent years have witnessed a fast growth in mathematical artificial intelligence (AI). One of the most successful mathematical AI approaches is topological data analysis (TDA) via persistent homology (PH) that provides explainable AI (xAI)…

General Topology · Mathematics 2025-10-27 Yiming Ren , Guowei Wei

Topological data analysis, as a tool for extracting topological features and characterizing geometric shapes, has experienced significant development across diverse fields. Its key mathematical techniques include persistent homology and the…

Algebraic Topology · Mathematics 2024-04-19 Jian Liu , Dong Chen , Guo-Wei Wei

Persistent Homology (PH) offers stable, multi-scale descriptors of intrinsic shape structure by capturing connected components, loops, and voids that persist across scales, providing invariants that complement purely geometric…

Computer Vision and Pattern Recognition · Computer Science 2026-04-07 Prachi Kudeshia , Jiju Poovvancheri , Amr Ghoneim , Dong Chen

Path homology proposed by S.-T.Yau and his co-workers provides a new mathematical model for directed graphs and networks. Persistent path homology (PPH) extends the path homology with filtration to deal with asymmetry structures. However,…

Algebraic Topology · Mathematics 2022-06-16 Rui Wang , Guo-Wei Wei

Persistent Homology (PH) is a fundamental tool in computational topology, designed to uncover the intrinsic geometric and topological features of data across multiple scales. Originating within the broader framework of Topological Data…

Algebraic Topology · Mathematics 2025-05-13 Aurelie Jodelle Kemme , Collins Amburo Agyingi

Topological Data Analysis (TDA) offers a suite of computational tools that provide quantified shape features in high dimensional data that can be used by modern statistical and predictive machine learning (ML) models. In particular,…

Cryptography and Security · Computer Science 2023-07-06 Dominic Gold , Koray Karabina , Francis C. Motta

Persistent homology (PH) is a rigorous mathematical theory that provides a robust descriptor of data in the form of persistence diagrams (PDs). PDs exhibit, however, complex structure and are difficult to integrate in today's machine…

Machine Learning · Statistics 2019-06-11 Bartosz Zieliński , Michał Lipiński , Mateusz Juda , Matthias Zeppelzauer , Paweł Dłotko

We use persistent homology along with the eigenfunctions of the Laplacian to study similarity amongst triangulated 2-manifolds. Our method relies on studying the lower-star filtration induced by the eigenfunctions of the Laplacian. This…

Machine Learning · Statistics 2019-04-25 Yunhao Zhang , Haowen Liu , Paul Rosen , Mustafa Hajij

Persistent homology (PH) is a method used in topological data analysis (TDA) to study qualitative features of data that persist across multiple scales. It is robust to perturbations of input data, independent of dimensions and coordinates,…

Algebraic Topology · Mathematics 2017-09-13 Nina Otter , Mason A. Porter , Ulrike Tillmann , Peter Grindrod , Heather A. Harrington

The de Rham-Hodge theory is a landmark of the 20$^\text{th}$ Century's mathematics and has had a great impact on mathematics, physics, computer science, and engineering. This work introduces an evolutionary de Rham-Hodge method to provide a…

Differential Geometry · Mathematics 2020-01-01 Jiahui Chen , Rundong Zhao , Yiying Tong , Guo-Wei Wei

Persistent homology is a powerful tool for characterizing the topology of a data set at various geometric scales. When applied to the description of molecular structures, persistent homology can capture the multiscale geometric features and…

Quantitative Methods · Quantitative Biology 2018-07-31 Zixuan Cang , Guo-Wei Wei

Directionality in molecular and biomolecular networks plays a significant role in the accurate represention of the complex, dynamic, and asymmetrical nature of interactions present in protein-ligand binding, signal transduction, and…

Biomolecules · Quantitative Biology 2024-11-08 Mushal Zia , Benjamin Jones , Hongsong Feng , Guo-Wei Wei

Persistent homology (PH) is one of the most popular methods in Topological Data Analysis. Even though PH has been used in many different types of applications, the reasons behind its success remain elusive; in particular, it is not known…

Algebraic Topology · Mathematics 2023-01-18 Renata Turkeš , Guido Montúfar , Nina Otter

Topological data analysis (TDA) has had enormous success in science and engineering in the past decade. Persistent topological Laplacians (PTLs) overcome some limitations of persistent homology, a key technique in TDA, and provide…

Algebraic Topology · Mathematics 2023-12-05 Benjamin Jones , Guowei Wei

Let $M^n$ be a compact orientable smooth Riemannian submanifold of dimension $n\geq 3$ in $\mathbb R^d$. We construct a family of deformed Hodge Laplacians $\Delta_t^*$, $t>0$, acting on differential forms and defined through the extrinsic…

Differential Geometry · Mathematics 2026-05-26 Hông Vân Lê
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