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Background: Designing amino acid sequences that are stable in a given target structure amounts to maximizing a conditional probability. A straightforward approach to accomplish this is a nested Monte Carlo where the conformation space is…

Soft Condensed Matter · Physics 2016-08-31 Anders Irbäck , Carsten Peterson , Frank Potthast , Erik Sandelin

Despite more than 100 years of study, it is unclear if the movement of proteins inside the cell is best described as a mosh pit or an exquisitely choreographed dance. Recent studies suggest the latter. Local interactions induce molecular…

Quantitative Methods · Quantitative Biology 2023-08-25 James A. Galbraith , Catherine G. Galbraith

Exploring the intricate dynamics between muscular and skeletal structures is pivotal for understanding human motion. This domain presents substantial challenges, primarily attributed to the intensive resources required for acquiring ground…

Computer Vision and Pattern Recognition · Computer Science 2024-11-04 David Schneider , Simon Reiß , Marco Kugler , Alexander Jaus , Kunyu Peng , Susanne Sutschet , M. Saquib Sarfraz , Sven Matthiesen , Rainer Stiefelhagen

Bayesian inference using Markov Chain Monte Carlo (MCMC) on large datasets has developed rapidly in recent years. However, the underlying methods are generally limited to relatively simple settings where the data have specific forms of…

Methodology · Statistics 2020-02-18 Robert Salomone , Matias Quiroz , Robert Kohn , Mattias Villani , Minh-Ngoc Tran

The number of resident space objects is rising at an alarming rate. Mega-constellations and breakup events are proliferating in most orbital regimes, and safe navigation is becoming increasingly problematic. It is important to be able to…

Instrumentation and Methods for Astrophysics · Physics 2025-04-11 Yannick Sztamfater Garcia , Joaquin Miguez , Manuel Sanjurjo-Rivo

We present a data-driven analysis of MOCK, $\Delta$-MOCK, and MOCLE. These are three closely related approaches that use multi-objective optimization for crisp clustering. More specifically, based on a collection of 12 datasets presenting…

Machine Learning · Computer Science 2021-10-26 Adriano Kultzak , Cristina Y. Morimoto , Aurora Pozo , Marcílio C. P. de Souto

Molecular dynamics (MD) simulations present a data-mining challenge, given that they can generate a considerable amount of data but often rely on limited or biased human interpretation to examine their information content. By not asking the…

Materials Science · Physics 2025-07-31 Fabrice Roncoroni , Ana Sanz-Matias , Siddharth Sundararaman , David Prendergast

We present a novel probabilistic clustering model for objects that are represented via pairwise distances and observed at different time points. The proposed method utilizes the information given by adjacent time points to find the…

Machine Learning · Computer Science 2015-04-16 Julia E. Vogt , Marius Kloft , Stefan Stark , Sudhir S. Raman , Sandhya Prabhakaran , Volker Roth , Gunnar Rätsch

Global fits of physics models require efficient methods for exploring high-dimensional and/or multimodal posterior functions. We introduce a novel method for accelerating Markov Chain Monte Carlo (MCMC) sampling by pairing a…

High Energy Physics - Phenomenology · Physics 2023-09-06 N. T. Hunt-Smith , W. Melnitchouk , F. Ringer , N. Sato , A. W Thomas , M. J. White

We propose a novel model-based clustering approach for samples of time series. We assume as a unique commonality that two observations belong to the same group if structural changes in their behaviours happen at the same time. We resort to…

Methodology · Statistics 2024-10-15 Riccardo Corradin , Luca Danese , Wasiur R. KhudaBukhsh , Andrea Ongaro

A plethora of multi-view subspace clustering (MVSC) methods have been proposed over the past few years. Researchers manage to boost clustering accuracy from different points of view. However, many state-of-the-art MVSC algorithms, typically…

Machine Learning · Computer Science 2019-11-22 Zhao Kang , Wangtao Zhou , Zhitong Zhao , Junming Shao , Meng Han , Zenglin Xu

Spatio-temporal clustering occupies an established role in various fields dealing with geospatial analysis, spanning from healthcare analysis to environmental science. One major challenge are applications in which cluster assignments are…

Computation · Statistics 2023-11-09 Ben Moews , Antonia Gieschen

The transition from petascale to exascale computers is characterized by substantial changes in the computer architectures and technologies. The research community relying on computational simulations is being forced to revisit the…

Computational Engineering, Finance, and Science · Computer Science 2015-11-02 Travis Johnston , Boyu Zhang , Adam Liwo , Silvia Crivelli , Michela Taufer

Spectral clustering requires the time-consuming decomposition of the Laplacian matrix of the similarity graph, thus limiting its applicability to large datasets. To improve the efficiency of spectral clustering, a top-down approach was…

Machine Learning · Computer Science 2024-12-19 Zhichang Xu , Zhiguo Long , Hua Meng

Molecular Dynamics (MD) simulations are essential for understanding the atomic-level behavior of molecular systems, giving insights into their transitions and interactions. However, classical MD techniques are limited by the trade-off…

Biomolecules · Quantitative Biology 2026-04-21 Ziyang Yu , Wenbing Huang , Yang Liu

Methods to extract information from the tracking of mobile objects/particles have broad interest in biological and physical sciences. Techniques based on simple criteria of proximity in time-consecutive snapshots are useful to identify the…

Data Analysis, Statistics and Probability · Physics 2015-03-13 M. Chertkov , L. Kroc , F. Krzakala , M. Vergassola , L. Zdeborová

This paper studies a discrete dynamical system belonging to the class of the networks introduced by A.P.~Buslaev. The systems contains a finite set of contours. In any contour, there are cells and a group of particles. This group is called…

Optimization and Control · Mathematics 2021-12-28 P. A. Myshkis , A. G. Tatashev , M. V. Yashina

Missing value problem in spatiotemporal traffic data has long been a challenging topic, in particular for large-scale and high-dimensional data with complex missing mechanisms and diverse degrees of missingness. Recent studies based on…

Machine Learning · Statistics 2021-06-15 Xinyu Chen , Yixian Chen , Nicolas Saunier , Lijun Sun

We consider the problem of estimating the measure of subsets in very large networks. A prime tool for this purpose is the Markov Chain Monte Carlo (MCMC) algorithm. This algorithm, while extremely useful in many cases, still often suffers…

Data Structures and Algorithms · Computer Science 2020-09-01 Ahmad Askarian , Rupei Xu , András Faragó

Monte Carlo methods are widely used to estimate observables in many-body quantum systems. However, conventional sampling schemes often require a large number of samples to achieve sufficient accuracy. In this work we propose the…

Quantum Physics · Physics 2026-01-29 Wenxuan Zhang , Dingzu Wang , Dario Poletti