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The higher criticism of a family of tests starts with the individual uncorrected p-values of each test. It then requires a procedure for deciding whether the collection of p-values indicates the presence of a real effect and if possible…

Practitioners often navigate LLM performance trade-offs by plotting Pareto frontiers of optimal accuracy-cost trade-offs. However, this approach offers no way to compare between LLMs with distinct strengths and weaknesses: for example, a…

Artificial Intelligence · Computer Science 2025-07-08 Michael J. Zellinger , Matt Thomson

In software development process we come across various modules. Which raise the idea of priority of the different modules of a software so that important modules are tested on preference. This approach is desirable because it is not…

Software Engineering · Computer Science 2009-05-10 Amit K Awasthi , Sanjay Chaudhary

The problem of simple $M-$ary hypothesis testing under a generic performance criterion that depends on arbitrary functions of error probabilities is considered. Using results from convex analysis, it is proved that an optimal decision rule…

Signal Processing · Electrical Eng. & Systems 2019-07-26 Berkan Dulek , Cuneyd Ozturk , Sinan Gezici

The problem of multiple hypothesis testing arises when there are more than one hypothesis to be tested simultaneously for statistical significance. This is a very common situation in many data mining applications. For instance, assessing…

Machine Learning · Statistics 2009-06-30 Sami Hanhijärvi , Kai Puolamäki , Gemma C. Garriga

There are many different notions of optimality even in testing a single hypothesis. In the multiple testing area, the number of possibilities is very much greater. The paper first will describe multiplicity issues that arise in tests…

Statistics Theory · Mathematics 2007-06-13 Juliet Popper Shaffer

Testing between hypotheses, when independent sampling is possible, is a well developed subject. In this paper, we propose hypothesis tests that are applicable when the samples are obtained using Markov chain Monte Carlo. These tests are…

Methodology · Statistics 2015-08-14 Benjamin M. Gyori , Daniel Paulin

Combining test statistics from independent trials or experiments is a popular method of meta-analysis. However, there is very limited theoretical understanding of the power of the combined test, especially in high-dimensional models…

Statistics Theory · Mathematics 2023-10-31 Botond Szabó , Aad van der Vaart , Lasse Vuursteen , Harry van Zanten

Large language models (LLMs) are increasingly deployed as autonomous decision agents in settings with asymmetric error costs: hiring (missed talent vs wasted interviews), medical triage (missed emergencies vs unnecessary escalation), and…

Artificial Intelligence · Computer Science 2026-01-06 Danial Amin

Major advances have been made regarding the utilization of artificial intelligence in health care. In particular, deep learning approaches have been successfully applied for automated and assisted disease diagnosis and prognosis based on…

Methodology · Statistics 2020-03-24 Max Westphal , Antonia Zapf , Werner Brannath

In traditional hypothesis testing one must pre-specify the significance level $\alpha$ to bound the `size' of the test: its probability to falsely reject the hypothesis. Indeed, a data-dependent selection of $\alpha$ would generally distort…

Statistics Theory · Mathematics 2025-12-03 Nick W. Koning

Modern statisticians are often presented with hundreds or thousands of hypothesis testing problems to evaluate at the same time, generated from new scientific technologies such as microarrays, medical and satellite imaging devices, or flow…

Applications · Statistics 2008-12-18 Bradley Efron

The validity of classical hypothesis testing requires the significance level $\alpha$ be fixed before any statistical analysis takes place. This is a stringent requirement. For instance, it prohibits updating $\alpha$ during (or after) an…

Statistics Theory · Mathematics 2026-01-21 Ben Chugg , Tyron Lardy , Aaditya Ramdas , Peter Grünwald

We propose and analyze a method for computing failure probabilities of systems modeled as numerical deterministic models (e.g., PDEs) with uncertain input data. A failure occurs when a functional of the solution to the model is below (or…

Numerical Analysis · Mathematics 2016-06-21 Daniel Elfverson , Fredrik Hellman , Axel Målqvist

Neyman and Pearson's theory of testing hypotheses does not warrant minimal epistemic reliability: the feature of driving to true conclusions more often than to false ones. The theory does not protect from the possible negative effects of…

Statistics Theory · Mathematics 2021-07-07 Adam P. Kubiak , Pawel Kawalec , Adam Kiersztyn

We revisit the outlier hypothesis testing framework of Li \emph{et al.} (TIT 2014) and derive fundamental limits for the optimal test. In outlier hypothesis testing, one is given multiple observed sequences, where most sequences are…

Statistics Theory · Mathematics 2022-05-17 Lin Zhou , Yun Wei , Alfred Hero

We study the Non-Homogeneous Sequential Hypothesis Testing (NHSHT), where a single active Decision-Maker (DM) selects actions with heterogeneous positive costs to identify the true hypothesis under an average error constraint \(\delta\),…

Information Theory · Computer Science 2025-10-01 George Vershinin , Asaf Cohen , Omer Gurewitz

We analyze the sample complexity of learning from multiple experiments where the experimenter has a total budget for obtaining samples. In this problem, the learner should choose a hypothesis that performs well with respect to multiple…

Machine Learning · Computer Science 2019-07-16 Longyun Guo , Jean Honorio , John Morgan

In epidemic or pandemic situations, resources for testing the infection status of individuals may be scarce. Although group testing can help to significantly increase testing capabilities, the (repeated) testing of entire populations can…

Populations and Evolution · Quantitative Biology 2021-10-29 Günther Koliander , Georg Pichler

Scientists often adjust their significance threshold (alpha level) during null hypothesis significance testing in order to take into account multiple testing and multiple comparisons. This alpha adjustment has become particularly relevant…

Methodology · Statistics 2021-07-08 Mark Rubin