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Multiplexed imaging allows multiple cell types to be simultaneously visualised in a single tissue sample, generating unprecedented amounts of spatially-resolved, biological data. In topological data analysis, persistent homology provides…

Quantitative Methods · Quantitative Biology 2025-05-06 Maria Torras-Pérez , Iris H. R. Yoon , Praveen Weeratunga , Ling-Pei Ho , Helen M. Byrne , Ulrike Tillmann , Heather A. Harrington

Time dependence is a universal phenomenon in nature, and a variety of mathematical models in terms of dynamical systems have been developed to understand the time-dependent behavior of real-world problems. Originally constructed to analyze…

Algebraic Topology · Mathematics 2018-02-14 Zixuan Cang , Elizabeth Munch , Guo-Wei Wei

Topological Data Analysis (TDA) is a rising field of computational topology in which the topological structure of a data set can be observed by persistent homology. By considering a sequence of sublevel sets, one obtains a filtration that…

Methodology · Statistics 2020-03-17 Yu-Min Chung , William Cruse , Austin Lawson

One of the paramount challenges in neuroscience is to understand the dynamics of individual neurons and how they give rise to network dynamics when interconnected. Historically, researchers have resorted to graph theory, statistics, and…

Neurons and Cognition · Quantitative Biology 2019-02-08 Jean-Baptiste Bardin , Gard Spreemann , Kathryn Hess

Persistence diagrams offer a way to summarize topological and geometric properties latent in datasets. While several methods have been developed that utilize persistence diagrams in statistical inference, a full Bayesian treatment remains…

Methodology · Statistics 2019-08-08 Vasileios Maroulas , Farzana Nasrin , Christopher Oballe

Topological features based on persistent homology capture high-order structural information so as to augment graph neural network methods. However, computing extended persistent homology summaries remains slow for large and dense graphs and…

Machine Learning · Computer Science 2022-11-16 Zuoyu Yan , Tengfei Ma , Liangcai Gao , Zhi Tang , Yusu Wang , Chao Chen

Hypergraph data appear and are hidden in many places in the modern age. They are data structure that can be used to model many real data examples since their structures contain information about higher order relations among data points. One…

Social and Information Networks · Computer Science 2020-10-02 Dong Quan Ngoc Nguyen , Lin Xing , Lizhen Lin

Graph embeddings have emerged as a powerful tool for representing complex network structures in a low-dimensional space, enabling the use of efficient methods that employ the metric structure in the embedding space as a proxy for the…

Social and Information Networks · Computer Science 2024-04-18 Radosław Nowak , Adam Małkowski , Daniel Cieślak , Piotr Sokół , Paweł Wawrzyński

Convolutional neural networks (CNNs) are a standard tool for computer vision tasks such as image classification. However, typical model architectures may result in the loss of topological information. In specific domains such as…

Image and Video Processing · Electrical Eng. & Systems 2026-03-05 Shrunal Pothagoni , Benjamin Schweinhart

Persistent homology (PH) is a powerful mathematical method to automatically extract relevant insights from images, such as those obtained by high-resolution imaging devices like electron microscopes or new-generation telescopes. However,…

Distributed, Parallel, and Cluster Computing · Computer Science 2024-04-15 Riccardo Ceccaroni , Lorenzo Di Rocco , Umberto Ferraro Petrillo , Pierpaolo Brutti

Topological data analysis and its main method, persistent homology, provide a toolkit for computing topological information of high-dimensional and noisy data sets. Kernels for one-parameter persistent homology have been established to…

Machine Learning · Computer Science 2019-06-06 René Corbet , Ulderico Fugacci , Michael Kerber , Claudia Landi , Bei Wang

Existing research highlights the crucial role of topological priors in image segmentation, particularly in preserving essential structures such as connectivity and genus. Accurately capturing these topological features often requires…

Computer Vision and Pattern Recognition · Computer Science 2026-01-19 Wenxiao Li , Xue-Cheng Tai , Jun Liu

We study the grokking phenomenon through the lens of topology. Using persistent homology on point clouds derived from the embedding matrices of a range of models trained on modular arithmetic with varying primes, we identify a clear and…

Machine Learning · Computer Science 2026-05-08 Yifan Tang , Qiquan Wang , Inés García-Redondo , Anthea Monod

Through the use of examples, we explain one way in which applied topology has evolved since the birth of persistent homology in the early 2000s. The first applications of topology to data emphasized the global shape of a dataset, such as…

Algebraic Topology · Mathematics 2021-04-23 Henry Adams , Michael Moy

Recent studies have actively employed persistent homology (PH), a topological data analysis technique, to analyze the topological information in time series data. Many successful studies have utilized graph representations of time series…

Algebraic Topology · Mathematics 2025-12-15 Eunwoo Heo , Jae-Hun Jung

Persistent Homology (PH) has been successfully used to train networks to detect curvilinear structures and to improve the topological quality of their results. However, existing methods are very global and ignore the location of topological…

Computer Vision and Pattern Recognition · Computer Science 2022-12-27 Doruk Oner , Adélie Garin , Mateusz Koziński , Kathryn Hess , Pascal Fua

Modern representation learning increasingly relies on unsupervised and self-supervised methods trained on large-scale unlabeled data. While these approaches achieve impressive generalization across tasks and domains, evaluating embedding…

One of the primary areas of interest in applied algebraic topology is persistent homology, and, more specifically, the persistence diagram. Persistence diagrams have also become objects of interest in topological data analysis. However,…

Methodology · Statistics 2018-04-06 Eric Berry , Yen-Chi Chen , Jessi Cisewski-Kehe , Brittany Terese Fasy

Thresholding--the pruning of nodes or edges based on their properties or weights--is an essential preprocessing tool for extracting interpretable structure from complex network data, yet existing methods face several key limitations.…

Social and Information Networks · Computer Science 2025-10-07 Adam Schroeder , Russell Funk , Jingyi Guan , Taylor Okonek , Lori Ziegelmeier

This paper introduces persistent homology, which is a powerful tool to characterize the shape of data using the mathematical concept of topology. We explain the fundamental idea of persistent homology from scratch using some examples. We…

Algebraic Topology · Mathematics 2022-05-25 Ippei Obayashi , Takenobu Nakamura , Yasuaki Hiraoka
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