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Drug discovery represents a time-consuming and financially intensive process, and virtual screening can accelerate it. Scoring functions, as one of the tools guiding virtual screening, have their precision closely tied to screening…

Machine Learning · Computer Science 2026-01-13 Haotian Gao , Xiangying Zhang , Jingyuan Li , Xinchong Chen , Haojie Wang , Yifei Qi , Renxiao Wang

Thanks to the success of deep learning, cross-modal retrieval has made significant progress recently. However, there still remains a crucial bottleneck: how to bridge the modality gap to further enhance the retrieval accuracy. In this…

Computer Vision and Pattern Recognition · Computer Science 2018-04-05 Chao Li , Cheng Deng , Ning Li , Wei Liu , Xinbo Gao , Dacheng Tao

Vision Transformer (ViT) has shown its advantages over the convolutional neural network (CNN) with its ability to capture global long-range dependencies for visual representation learning. Besides ViT, contrastive learning is another…

Computer Vision and Pattern Recognition · Computer Science 2022-07-12 Hua-Bao Ling , Bowen Zhu , Dong Huang , Ding-Hua Chen , Chang-Dong Wang , Jian-Huang Lai

Online continual learning, aimed at developing a neural network that continuously learns new data from a single pass over an online data stream, generally suffers from catastrophic forgetting. Existing replay-based methods alleviate…

Machine Learning · Computer Science 2025-01-06 Huiwei Lin , Shanshan Feng , Baoquan Zhang , Xutao Li , Yunming Ye

Content-defined Chunking (CDC) algorithms dictate the overall space savings that deduplication systems achieve. However, due to their need to scan each file in its entirety, they are slow and often the main performance bottleneck within…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-01-28 Sreeharsha Udayashankar , Abdelrahman Baba , Samer Al-Kiswany

Vector search (VS) has become a fundamental component in multimodal data management, enabling core functionalities such as image, video, and code retrieval. As vector data scales rapidly, VS faces growing challenges in balancing search,…

Databases · Computer Science 2026-01-06 Yitong Song , Xuanhe Zhou , Christian S. Jensen , Jianliang Xu

Drug discovery projects entail cycles of design, synthesis, and testing that yield a series of chemically related small molecules whose properties, such as binding affinity to a given target protein, are progressively tailored to a…

Machine Learning · Computer Science 2020-02-10 Paul Maragakis , Hunter Nisonoff , Brian Cole , David E. Shaw

Unsupervised semantic hashing has emerged as an indispensable technique for fast image search, which aims to convert images into binary hash codes without relying on labels. Recent advancements in the field demonstrate that employing…

Computer Vision and Pattern Recognition · Computer Science 2024-03-12 Liyang He , Zhenya Huang , Jiayu Liu , Enhong Chen , Fei Wang , Jing Sha , Shijin Wang

Hashing is widely applied to approximate nearest neighbor search for large-scale multimodal retrieval with storage and computation efficiency. Cross-modal hashing improves the quality of hash coding by exploiting semantic correlations…

Computer Vision and Pattern Recognition · Computer Science 2017-02-21 Yue Cao , Mingsheng Long , Jianmin Wang , Philip S. Yu

Drug repositioning (DR) refers to identification of novel indications for the approved drugs. The requirement of huge investment of time as well as money and risk of failure in clinical trials have led to surge in interest in drug…

Computation and Language · Computer Science 2017-05-23 Sahil Manchanda , Ashish Anand

Recently, with the enormous growth of online videos, fast video retrieval research has received increasing attention. As an extension of image hashing techniques, traditional video hashing methods mainly depend on hand-crafted features and…

Computer Vision and Pattern Recognition · Computer Science 2017-12-04 Yj Dong , JG Li

Contrastive learning is a powerful technique to learn representations that are semantically distinctive and geometrically invariant. While most of the earlier approaches have demonstrated its effectiveness on single-modality learning tasks…

Computer Vision and Pattern Recognition · Computer Science 2021-10-19 Anurag Jain , Yashaswi Verma

There is a growing trend in studying deep hashing methods for content-based image retrieval (CBIR), where hash functions and binary codes are learnt using deep convolutional neural networks and then the binary codes can be used to do…

Computer Vision and Pattern Recognition · Computer Science 2017-11-17 Deng Cai , Xiuye Gu , Chaoqi Wang

Drug-target interaction is fundamental in understanding how drugs affect biological systems, and accurately predicting drug-target affinity (DTA) is vital for drug discovery. Recently, deep learning methods have emerged as a significant…

Machine Learning · Computer Science 2024-12-30 Minghui Li , Zikang Guo , Yang Wu , Peijin Guo , Yao Shi , Shengshan Hu , Wei Wan , Shengqing Hu

Multiview clustering (MVC) aims to reveal the underlying structure of multiview data by categorizing data samples into clusters. Deep learning-based methods exhibit strong feature learning capabilities on large-scale datasets. For most…

Computer Vision and Pattern Recognition · Computer Science 2024-01-30 Jie Chen , Hua Mao , Wai Lok Woo , Xi Peng

Due to its storage and retrieval efficiency, cross-modal hashing~(CMH) has been widely used for cross-modal similarity search in multimedia applications. According to the training strategy, existing CMH methods can be mainly divided into…

Information Retrieval · Computer Science 2017-07-27 Qing-Yuan Jiang , Wu-Jun Li

Due to the high storage and search efficiency, hashing has become prevalent for large-scale similarity search. Particularly, deep hashing methods have greatly improved the search performance under supervised scenarios. In contrast,…

Computer Vision and Pattern Recognition · Computer Science 2019-05-10 Erkun Yang , Tongliang Liu , Cheng Deng , Wei Liu , Dacheng Tao

Binary codes have been widely used in vision problems as a compact feature representation to achieve both space and time advantages. Various methods have been proposed to learn data-dependent hash functions which map a feature vector to a…

Computer Vision and Pattern Recognition · Computer Science 2014-10-22 Jie Feng , Wei Liu , Yan Wang

Identification of drug-target interactions (DTIs) plays a key role in drug discovery. The high cost and labor-intensive nature of in vitro and in vivo experiments have highlighted the importance of in silico-based DTI prediction approaches.…

Quantitative Methods · Quantitative Biology 2019-09-11 Ingoo Lee , Jongsoo Keum , Hojung Nam

Hash representation learning of multi-view heterogeneous data is the key to improving the accuracy of multimedia retrieval. However, existing methods utilize local similarity and fall short of deeply fusing the multi-view features,…

Computer Vision and Pattern Recognition · Computer Science 2023-08-29 Jian Zhu , Wen Cheng , Yu Cui , Chang Tang , Yuyang Dai , Yong Li , Lingfang Zeng
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