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Although deep learning models in medical imaging often achieve excellent classification performance, they can rely on shortcut learning, exploiting spurious correlations or confounding factors that are not causally related to the target…

Computer Vision and Pattern Recognition · Computer Science 2026-04-15 Sarah Müller , Philipp Berens

Deep learning models can excel on medical tasks, yet often experience spurious correlations, known as shortcut learning, leading to poor generalization in new environments. Particularly in medical imaging, where multiple spurious…

Computer Vision and Pattern Recognition · Computer Science 2025-12-01 Louisa Fay , Hajer Reguigui , Bin Yang , Sergios Gatidis , Thomas Küstner

Shortcut learning is a phenomenon where machine learning models prioritize learning simple, potentially misleading cues from data that do not generalize well beyond the training set. While existing research primarily investigates this in…

Image and Video Processing · Electrical Eng. & Systems 2024-06-28 Manxi Lin , Nina Weng , Kamil Mikolaj , Zahra Bashir , Morten Bo Søndergaard Svendsen , Martin Tolsgaard , Anders Nymark Christensen , Aasa Feragen

Deep learning models were frequently reported to learn from shortcuts like dataset biases. As deep learning is playing an increasingly important role in the modern healthcare system, it is of great need to combat shortcut learning in…

Image and Video Processing · Electrical Eng. & Systems 2022-08-05 Luyang Luo , Dunyuan Xu , Hao Chen , Tien-Tsin Wong , Pheng-Ann Heng

Machine learning (ML) holds great promise for improving healthcare, but it is critical to ensure that its use will not propagate or amplify health disparities. An important step is to characterize the (un)fairness of ML models - their…

Machine Learning · Computer Science 2023-08-09 Alexander Brown , Nenad Tomasev , Jan Freyberg , Yuan Liu , Alan Karthikesalingam , Jessica Schrouff

While deep learning has shown promise in the domain of disease classification from medical images, models based on state-of-the-art convolutional neural network architectures often exhibit performance loss due to dataset shift. Models…

Machine Learning · Computer Science 2020-01-14 Joseph D. Janizek , Gabriel Erion , Alex J. DeGrave , Su-In Lee

Deep learning models in medical imaging are susceptible to shortcut learning, relying on confounding metadata (e.g., scanner model) that is often encoded in image embeddings. The crucial question is whether the model actively utilizes this…

Computer Vision and Pattern Recognition · Computer Science 2026-02-05 Chun Kit Wong , Paraskevas Pegios , Nina Weng , Emilie Pi Fogtmann Sejer , Martin Grønnebæk Tolsgaard , Anders Nymark Christensen , Aasa Feragen

The diversity of training datasets is usually perceived as an important aspect to obtain a robust model. However, the definition of diversity is often not defined or differs across papers, and while some metrics exist, the quantification of…

Computer Vision and Pattern Recognition · Computer Science 2026-03-17 Théo Sourget , Niclas Claßen , Jack Junchi Xu , Rob van der Goot , Veronika Cheplygina

Medical imaging foundation models must adapt over time, yet full retraining is often blocked by privacy constraints and cost. We present a continual learning framework that avoids storing patient exemplars by pairing class conditional…

Computer Vision and Pattern Recognition · Computer Science 2025-09-30 Anoushka Harit , William Prew , Zhongtian Sun , Florian Markowetz

Medical image enhancement is crucial for improving the quality and interpretability of diagnostic images, ultimately supporting early detection, accurate diagnosis, and effective treatment planning. Despite advancements in imaging…

Computer Vision and Pattern Recognition · Computer Science 2025-10-21 Chun Wai Chin , Haniza Yazid , Hoi Leong Lee

Deep learning is the state-of-the-art for medical imaging tasks, but requires large, labeled datasets. For risk prediction, large datasets are rare since they require both imaging and follow-up (e.g., diagnosis codes). However, the release…

Image and Video Processing · Electrical Eng. & Systems 2023-06-16 Yanru Chen , Michael T Lu , Vineet K Raghu

The field of medical diagnostics contains a wealth of challenges which closely resemble classical machine learning problems; practical constraints, however, complicate the translation of these endpoints naively into classical architectures.…

Computer Vision and Pattern Recognition · Computer Science 2018-02-05 Li Yao , Eric Poblenz , Dmitry Dagunts , Ben Covington , Devon Bernard , Kevin Lyman

Conventional and deep learning-based methods have shown great potential in the medical imaging domain, as means for deriving diagnostic, prognostic, and predictive biomarkers, and by contributing to precision medicine. However, these…

High-throughput biological imaging is often constrained by a trade-off between acquisition speed and image quality. Fast imaging modalities, such as wide-field fluorescence microscopy, enable large-scale data acquisition but suffer from…

Image and Video Processing · Electrical Eng. & Systems 2026-04-20 Dominik Panek , Carina Rząca , Maksymilian Szczypior , Joanna Sorysz , Krzysztof Misztal , Zbigniew Baster , Zenon Rajfur

With the development of deep learning, medical image classification has been significantly improved. However, deep learning requires massive data with labels. While labeling the samples by human experts is expensive and time-consuming,…

Image and Video Processing · Electrical Eng. & Systems 2021-09-14 Jiarun Liu , Ruirui Li , Chuan Sun

Deep learning has led to state-of-the-art results for many medical imaging tasks, such as segmentation of different anatomical structures. With the increased numbers of deep learning publications and openly available code, the approach to…

Image and Video Processing · Electrical Eng. & Systems 2020-05-19 Tom van Sonsbeek , Veronika Cheplygina

Medical imaging segmentation is a highly active area of research, with deep learning-based methods achieving state-of-the-art results in several benchmarks. However, the lack of standardized tools for training, testing, and evaluating new…

Image and Video Processing · Electrical Eng. & Systems 2024-11-19 Adrian Celaya , Evan Lim , Rachel Glenn , Brayden Mi , Alex Balsells , Dawid Schellingerhout , Tucker Netherton , Caroline Chung , Beatrice Riviere , David Fuentes

In this paper, we use spectral analysis to investigate transfer learning and study model sensitivity to frequency shortcuts in medical imaging. By analyzing the power spectrum density of both pre-trained and fine-tuned model gradients, as…

Computer Vision and Pattern Recognition · Computer Science 2025-05-13 Yucheng Lu , Dovile Juodelyte , Jonathan D. Victor , Veronika Cheplygina

Federated learning has attracted considerable interest for collaborative machine learning in healthcare to leverage separate institutional datasets while maintaining patient privacy. However, additional challenges such as poor calibration…

Machine Learning · Computer Science 2022-01-19 Charles Lu , Jayasheree Kalpathy-Cramer

Deep learning models trained in a fully supervised manner have been shown to rely on so-called "shortcut" features. Shortcut features are inputs that are associated with the outcome of interest in the training data, but are either no longer…

Machine Learning · Computer Science 2022-07-12 Anil Palepu , Andrew L Beam
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