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With the advancement of technology for artificial intelligence (AI) based solutions and analytics compute engines, machine learning (ML) models are getting more complex day by day. Most of these models are generally used as a black box…

Machine Learning · Computer Science 2022-10-11 P. Sai Ram Aditya , Mayukha Pal

In spite of the strong performance of machine learning (ML) models in radiology, they have not been widely accepted by radiologists, limiting clinical integration. A key reason is the lack of explainability, which ensures that model…

Human-Computer Interaction · Computer Science 2026-04-14 Sara Ketabi , Matthias W. Wagner , Birgit Betina Ertl-Wagner , Greg A. Jamieson , Farzad Khalvati

We propose Partially Interpretable Estimators (PIE) which attribute a prediction to individual features via an interpretable model, while a (possibly) small part of the PIE prediction is attributed to the interaction of features via a…

Machine Learning · Computer Science 2021-05-07 Tong Wang , Jingyi Yang , Yunyi Li , Boxiang Wang

Estimating causal effect using machine learning (ML) algorithms can help to relax functional form assumptions if used within appropriate frameworks. However, most of these frameworks assume settings with cross-sectional data, whereas…

Econometrics · Economics 2024-09-04 Jonathan Fuhr , Dominik Papies

Recent developments in single-cell omics technologies have enabled the quantification of molecular profiles in individual cells at an unparalleled resolution. Deep learning, a rapidly evolving sub-field of machine learning, has instilled a…

Genomics · Quantitative Biology 2024-01-17 Manoj M Wagle , Siqu Long , Carissa Chen , Chunlei Liu , Pengyi Yang

Interpretability can be critical for the safe and responsible use of machine learning models in high-stakes applications. So far, evolutionary computation (EC), in particular in the form of genetic programming (GP), represents a key enabler…

Neural and Evolutionary Computing · Computer Science 2022-04-06 Marco Virgolin , Eric Medvet , Tanja Alderliesten , Peter A. N. Bosman

Machine learning is increasingly transforming various scientific fields, enabled by advancements in computational power and access to large data sets from experiments and simulations. As artificial intelligence (AI) continues to grow in…

Computational Physics · Physics 2025-04-01 Sebastian Johann Wetzel , Seungwoong Ha , Raban Iten , Miriam Klopotek , Ziming Liu

In a world where Machine Learning (ML) is increasingly deployed to support decision-making in critical domains, providing decision-makers with explainable, stable, and relevant inputs becomes fundamental. Understanding how machine learning…

Machine Learning · Computer Science 2024-08-07 Karol Capała , Paulina Tworek , Jose Sousa

Deep Neural Networks have often been called the black box because of the complex, deep architecture and non-transparency presented by the inner layers. There is a lack of trust to use Artificial Intelligence in critical and high-precision…

Computer Vision and Pattern Recognition · Computer Science 2024-03-12 Frincy Clement , Ji Yang , Irene Cheng

Interpretable machine learning models offer understandable reasoning behind their decision-making process, though they may not always match the performance of their black-box counterparts. This trade-off between interpretability and model…

Artificial Intelligence · Computer Science 2025-03-12 Pranjal Atrey , Michael P. Brundage , Min Wu , Sanghamitra Dutta

The last decade witnessed an ever-increasing stream of successes in Machine Learning (ML). These successes offer clear evidence that ML is bound to become pervasive in a wide range of practical uses, including many that directly affect…

Artificial Intelligence · Computer Science 2023-01-31 Joao Marques-Silva

In machine learning algorithm design, there exists a trade-off between the interpretability and performance of the algorithm. In general, algorithms which are simpler and easier for humans to comprehend tend to show worse performance than…

Machine Learning · Computer Science 2024-07-15 Eric M. Vernon , Naoki Masuyama , Yusuke Nojima

Machine learning models have had discernible achievements in a myriad of applications. However, most of these models are black-boxes, and it is obscure how the decisions are made by them. This makes the models unreliable and untrustworthy.…

Machine Learning · Computer Science 2020-03-23 Raha Moraffah , Mansooreh Karami , Ruocheng Guo , Adrienne Raglin , Huan Liu

EXplainable machine learning (XML) has recently emerged to address the mystery mechanisms of machine learning (ML) systems by interpreting their 'black box' results. Despite the development of various explanation methods, determining the…

Human-Computer Interaction · Computer Science 2025-03-03 Bo Wang , Yiqiao Li , Jianlong Zhou , Fang Chen

Machine learning (ML) methods are being used in almost every conceivable area of electronic structure theory and molecular simulation. In particular, ML has become firmly established in the construction of high-dimensional interatomic…

Chemical Physics · Physics 2021-06-22 Julia Westermayr , Michael Gastegger , Kristof T. Schütt , Reinhard J. Maurer

The ability to interpret Machine Learning (ML) models is becoming increasingly essential. However, despite significant progress in the field, there remains a lack of rigorous characterization regarding the innate interpretability of…

Machine Learning · Computer Science 2024-08-08 Guy Amir , Shahaf Bassan , Guy Katz

Large language models (LLMs), trained on vast datasets, encode extensive real-world knowledge within their parameters, yet their black-box nature obscures the mechanisms and extent of this encoding. Surrogate modeling, which uses simplified…

Computation and Language · Computer Science 2026-04-24 Changho Han , Songsoo Kim , Dong Won Kim , Leo Anthony Celi , Jaewoong Kim , SungA Bae , Dukyong Yoon

The need for transparency of predictive systems based on Machine Learning algorithms arises as a consequence of their ever-increasing proliferation in the industry. Whenever black-box algorithmic predictions influence human affairs, the…

Machine Learning · Computer Science 2020-02-11 Kacper Sokol , Peter Flach

Prediction of survival in patients diagnosed with a brain tumour is challenging because of heterogeneous tumour behaviours and responses to treatment. Better estimations of prognosis would support treatment planning and patient support.…

Machine Learning · Computer Science 2021-06-18 Colleen E. Charlton , Michael Tin Chung Poon , Paul M. Brennan , Jacques D. Fleuriot

One of the desired key properties of deep learning models is the ability to generalise to unseen samples. When provided with new samples that are (perceptually) similar to one or more training samples, deep learning models are expected to…

Sound · Computer Science 2025-08-07 Katharina Hoedt , Arthur Flexer , Gerhard Widmer