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In multisite trials, researchers are often interested in several inferential goals: estimating treatment effects for each site, ranking these effects, and studying their distribution. This study seeks to identify optimal methods for…

Methodology · Statistics 2024-04-03 JoonHo Lee , Jonathan Che , Sophia Rabe-Hesketh , Avi Feller , Luke Miratrix

Randomized trials are often conducted with separate randomizations across multiple sites such as schools, voting districts, or hospitals. These sites can differ in important ways, including the site's implementation, local conditions, and…

Methodology · Statistics 2018-03-19 Lo-Hua Yuan , Avi Feller , Luke W. Miratrix

Investigators often use multi-source data (e.g., multi-center trials, meta-analyses of randomized trials, pooled analyses of observational cohorts) to learn about the effects of interventions in subgroups of some well-defined target…

Methodology · Statistics 2024-02-06 Guanbo Wang , Alexander Levis , Jon Steingrimsson , Issa Dahabreh

Local decision rules are commonly understood to be more explainable, due to the local nature of the patterns involved. With numerical optimization methods such as gradient boosting, ensembles of local decision rules can gain good predictive…

Machine Learning · Computer Science 2025-08-27 Xin Du , Subramanian Ramamoorthy , Wouter Duivesteijn , Jin Tian , Mykola Pechenizkiy

Federated or multi-site studies have distinct advantages over single-site studies, including increased generalizability, the ability to study underrepresented populations, and the opportunity to study rare exposures and outcomes. However,…

Machine Learning · Statistics 2023-09-25 Larry Han , Zhu Shen , Jose Zubizarreta

This paper is based on a case study of an IT organization in a large, US-based healthcare provider, and develops simluation models to identify areas for performance improvement. These organizations are often grouped into departments by…

Systems and Control · Electrical Eng. & Systems 2024-02-23 Eric Enos , Daniel Herber

Recently, there has been great interest in estimating the conditional average treatment effect using flexible machine learning methods. However, in practice, investigators often have working hypotheses about effect heterogeneity across…

Methodology · Statistics 2023-09-13 Chan Park , Hyunseung Kang

Cluster randomized trials (CRTs) randomly assign an intervention to groups of individuals (e.g., clinics or communities) and measure outcomes on individuals in those groups. While offering many advantages, this experimental design…

Distribution shifts are ubiquitous in real-world machine learning applications, posing a challenge to the generalization of models trained on one data distribution to another. We focus on scenarios where data distributions vary across…

Machine Learning · Statistics 2024-06-05 Steven Wilkins-Reeves , Xu Chen , Qi Ma , Christine Agarwal , Aude Hofleitner

A new method is proposed to explore sources of cross-site impact variance in multi-site trials of social interventions. With this approach, aggregate reports from participants in the treatment arm about the treatment experience are used to…

Applications · Statistics 2021-12-03 David R. Judkins , Gabriel Durham

Multi-Agent Reinforcement Learning can lead to the development of collaborative agent behaviors that show similarities with organizational concepts. Pushing forward this perspective, we introduce a novel framework that explicitly…

Artificial Intelligence · Computer Science 2025-04-01 Julien Soulé , Jean-Paul Jamont , Michel Occello , Louis-Marie Traonouez , Paul Théron

Many programs evaluated in observational studies incorporate a sequential structure, where individuals may be assigned to various programs over time. While this complexity is often simplified by analyzing programs at single points in time,…

Econometrics · Economics 2025-06-16 Fabian Muny

We often seek to estimate the impact of an exposure naturally occurring or randomly assigned at the cluster-level. For example, the literature on neighborhood determinants of health continues to grow. Likewise, community randomized trials…

Methodology · Statistics 2021-07-08 Laura B. Balzer , Wenjing Zheng , Mark J. van der Laan , Maya L. Petersen

Researchers often face data fusion problems, where multiple data sources are available, each capturing a distinct subset of variables. While problem formulations typically take the data as given, in practice, data acquisition can be an…

Machine Learning · Computer Science 2021-11-02 Shantanu Gupta , Zachary C. Lipton , David Childers

The allocation of limited resources to a large number of potential candidates presents a pervasive challenge. In the context of ranking and selecting top candidates from heteroscedastic units, conventional methods often result in…

Methodology · Statistics 2023-06-16 Bowen Gang , Luella Fu , Gareth James , Wenguang Sun

When we plan to use money as an incentive to change the behavior of a person (such as making riders to deliver more orders or making consumers to buy more items), the common approach of this problem is to adopt a two-stage framework in…

Machine Learning · Computer Science 2025-04-08 Juhua Chen , Karson shi , Jialing He , North Chen , Kele Jiang

Many reinforcement learning (RL) environments consist of independent entities that interact sparsely. In such environments, RL agents have only limited influence over other entities in any particular situation. Our idea in this work is that…

Machine Learning · Computer Science 2021-12-03 Maximilian Seitzer , Bernhard Schölkopf , Georg Martius

Scrum teams are at the heart of the Scrum framework. Nevertheless, an integrated and systemic theory that can explain what makes some Scrum teams more effective than others is still missing. To address this gap, we performed a…

Software Engineering · Computer Science 2022-04-28 Christiaan Verwijs , Daniel Russo

Causal effect estimation from observational data is a challenging problem, especially with high dimensional data and in the presence of unobserved variables. The available data-driven methods for tackling the problem either provide an…

Methodology · Statistics 2022-07-25 Debo Cheng , Jiuyong Li , Lin Liu , Jiji Zhang , Jixue Liu , Thuc Duy Le

This paper introduces a model of multi-unit organizations with either static structures, i.e., they are designed top-down following classical approaches to organizational design, or dynamic structures, i.e., the structures emerge over time…

General Economics · Economics 2022-09-12 Stephan Leitner
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