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Motivated by recent experimental results for the step sizes of dynein motor proteins, we develope a cellular automata model for intra-cellular traffic of dynein motors incorporating special features of the hindrance-dependent step size of…

Statistical Mechanics · Physics 2009-11-11 Ambarish Kunwar , Andreas Schadschneider , Debashish Chowdhury

Recent experiments (G. Ariel, et al., Nature Comm. 6, 8396 (2015)) revealed an intriguing behavior of swarming bacteria: they fundamentally change their collective motion from simple diffusion into a superdiffusive L\'{e}vy walk dynamics.…

Statistical Mechanics · Physics 2017-04-05 Sergei Fedotov , Nickolay Korabel

We propose a stochastic model for intracellular transport processes associated with the activity of molecular motors. This out-of-equilibrium model, based on a generalized Langevin equation, considers a particle immersed in a viscoelastic…

Biological Physics · Physics 2009-04-15 L. Bruno , M. A. Despósito

Intracellular transport of DNA carriers is a fundamental step of gene delivery. We present here a theoretical approach to study generically a single virus or DNA particle trafficking in a cell cytoplasm. Cellular trafficking has been…

Quantitative Methods · Quantitative Biology 2007-11-28 T. Lagache , E. Dauty , D. Holcman

The neural dynamics of the nematode C. elegans are experimentally low-dimensional and correspond to discrete behavioral states, where previous modeling work has found neural proxies for some of these states. Experimental results further…

Neurons and Cognition · Quantitative Biology 2015-09-04 James Kunert , Eli Shlizerman , Andrew Walker , J. Nathan Kutz

During migration cells exhibit a rich variety of seemingly random migration patterns, which makes unraveling the underlying mechanisms that control cell migration a daunting challenge. For efficient migration cells require a mechanism for…

Biological Physics · Physics 2020-08-19 Jonathan E. Ron , Pascale Monzo , Nils Gauthier , Raphael Voituriez , Nir S. Gov

Microtubules (MTs) nucleated by centrosomes form star-shaped structures referred to as asters. Aster motility and dynamics is vital for genome stability, cell division, polarization and differentiation. Asters move either towards the cell…

Subcellular Processes · Quantitative Biology 2019-05-21 Chaitanya A. Athale , Ana Dinarina , Francois Nedelec , Eric Karsenti

We propose a theoretical model which relies on the generalized Langevin equation and may account for various dynamical features of the thermal motion of organelles, vesicles or macromolecules in viscoelastic media such as polymer networks.…

Soft Condensed Matter · Physics 2020-01-03 Denis S. Grebenkov , Mahsa Vahabi , Elena Bertseva , Laszlo Forro , Sylvia Jeney

Cell crawling is critical to biological development, homeostasis and disease. In many cases, cell trajectories are quasi-random-walk. In vitro assays on flat surfaces often described such quasi-random-walk cell trajectories as…

We study the motion of random walkers with residence time bias between first and subsequent visits to a site, as a model for synthetic molecular walkers composed of coupled DNAzyme legs known as molecular spiders. The mechanism of the…

Biological Physics · Physics 2020-07-01 David Arredondo , Darko Stefanovic

The ensemble properties and time-averaged observables of a memory-induced diffusive-superdiffusive transition are studied. The model consists in a random walker whose transitions in a given direction depend on a weighted linear combination…

Statistical Mechanics · Physics 2017-05-11 Adrian A. Budini

In many biological systems, the movement of individual agents is commonly characterized as having multiple qualitatively distinct behaviors that arise from various biophysical states. This is true for vesicles in intracellular transport,…

Subcellular Processes · Quantitative Biology 2022-07-25 Maria-Veronica Ciocanel , John Fricks , Peter R. Kramer , Scott A. McKinley

We investigate the electron (hole) transport through short double-stranded DNA wires in which the electrons are strongly coupled to the specific vibrational modes (vibrons) of the DNA. We analyze the problem starting from a tight-binding…

Mesoscale and Nanoscale Physics · Physics 2015-06-25 Benjamin B. Schmidt , Matthias H. Hettler , Gerd Schön

We study the persistent random walk of photons on a one-dimensional lattice of random transmittances. Transmittances at different sites are assumed independent, distributed according to a given probability density $f(t)$. Depending on the…

Statistical Mechanics · Physics 2007-05-23 MirFaez Miri , Zeinab Sadjadi , M. Ebrahim Fouladvand

Myosin-V is a highly processive dimeric protein that walks with 36nm steps along actin tracks, powered by coordinated ATP hydrolysis reactions in the two myosin heads. No previous theoretical models of the myosin-V walk reproduce all the…

Biomolecules · Quantitative Biology 2015-06-22 Neville J. Boon , Rebecca B. Hoyle

We consider a tracer particle performing a random walk on a two-dimensional lattice in the presence of immobile hard obstacles. Starting from equilibrium, a constant force pulling on the particle is switched on, driving the system to a new…

Statistical Mechanics · Physics 2024-09-05 Dan Shafir , Alessio Squarcini , Stanislav Burov , Thomas Franosch

We study the dynamics of membrane vesicle motor transport into dendritic spines, which are bulbous intracellular compartments in neurons that play a key role in transmitting signals between neurons. We consider the stochastic analog of the…

Subcellular Processes · Quantitative Biology 2022-05-17 Youngmin Park , Prashant Singh , Thomas G. Fai

We introduce a discrete-time random walk model on a one-dimensional lattice with a nonconstant sojourn time and prove that the discrete density converges to a solution of a continuum diffusion equation. Our random walk model is not…

Analysis of PDEs · Mathematics 2023-02-14 Jaywan Chung , Yong-Jung Kim , Min-Gi Lee

We perform a bidimensional Stokes experiment in an active cellular material: an autonomously migrating monolayer of Madin-Darby Canine Kidney (MDCK) epithelial cells flows around a circular obstacle within a long and narrow channel,…

Tissues and Organs · Quantitative Biology 2020-08-26 S. Tlili , M. Durande , C. Gay , B. Ladoux , F. Graner , H. Delanoë-Ayari

To fulfill their killing functions, cytotoxic T lymphocytes (CTLs) need to migrate to search for their target cells in complex biological microenvironments, a key component of which is extracellular matrix (ECM). The mechanisms underlying…

Biological Physics · Physics 2020-12-30 Z. Sadjadi , R. Zhao , M. Hoth , B. Qu , H. Rieger