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Observability is a modelling property that describes the possibility of inferring the internal state of a system from observations of its output. A related property, structural identifiability, refers to the theoretical possibility of…

Quantitative Methods · Quantitative Biology 2018-12-12 Alejandro F. Villaverde

We focus on causal discovery in the presence of measurement error in linear systems where the mixing matrix, i.e., the matrix indicating the independent exogenous noise terms pertaining to the observed variables, is identified up to…

Machine Learning · Computer Science 2022-11-09 Yuqin Yang , AmirEmad Ghassami , Mohamed Nafea , Negar Kiyavash , Kun Zhang , Ilya Shpitser

Existing approaches to causal discovery often rely on restrictive modeling assumptions that limit their applicability in real-world settings, particularly when data are heavy-tailed or contain a mixture of discrete and continuous variables.…

Methodology · Statistics 2025-11-25 Juraj Bodik , Valérie Chavez-Demoulin

Prediction invariance of causal models under heterogeneous settings has been exploited by a number of recent methods for causal discovery, typically focussing on recovering the causal parents of a target variable of interest. Existing…

Methodology · Statistics 2026-03-10 Alice Polinelli , Veronica Vinciotti , Ernst C. Wit

When employing mechanistic models to study biological phenomena, practical parameter identifiability is important for making accurate predictions across wide range of unseen scenarios, as well as for understanding the underlying mechanisms.…

Quantitative Methods · Quantitative Biology 2023-10-19 Yue Liu , Kevin Suh , Philip K. Maini , Daniel J. Cohen , Ruth E. Baker

Here we introduce Partially Observed Structural Causal Models (POSCMs) that formalize causal systems where latent contexts co-determine both the interaction structure and downstream mechanisms on observed variables. POSCMs provide an…

Machine Learning · Computer Science 2026-05-06 Turan Orujlu , Jordan Matelsky , Martin V. Butz , Charley M. Wu , Konrad P. Kording

Parameter identifiability is often requisite to the effective application of mathematical models in the interpretation of biological data, however theory applicable to the study of partial differential equations remains limited. We present…

Analysis of PDEs · Mathematics 2025-04-08 Yurij Salmaniw , Alexander P Browning

The goal of causal representation learning is to find a representation of data that consists of causally related latent variables. We consider a setup where one has access to data from multiple domains that potentially share a causal…

Machine Learning · Statistics 2023-10-30 Nils Sturma , Chandler Squires , Mathias Drton , Caroline Uhler

Causal representation learning seeks to recover latent factors that generate observational data through a mixing function. Needing assumptions on latent structures or relationships to achieve identifiability in general, prior works often…

Artificial Intelligence · Computer Science 2025-09-24 Kwonho Kim , Heejeong Nam , Inwoo Hwang , Sanghack Lee

Nonlinear causal discovery from observational data imposes strict identifiability assumptions on the formulation of structural equations utilized in the data generating process. The evaluation of structure learning methods under assumption…

Machine Learning · Statistics 2024-12-17 Georg Velev , Stefan Lessmann

Stochasticity plays a key role in many biological systems, necessitating the calibration of stochastic mathematical models to interpret associated data. For model parameters to be estimated reliably, it is typically the case that they must…

Unmeasured confounding presents a common challenge in observational studies, potentially making standard causal parameters unidentifiable without additional assumptions. Given the increasing availability of diverse data sources, exploiting…

Methodology · Statistics 2023-09-18 Shanshan Luo , Yechi Zhang , Wei Li

Causal inference from observational data is crucial for many disciplines such as medicine and economics. However, sharp bounds for causal effects under relaxations of the unconfoundedness assumption (causal sensitivity analysis) are subject…

Machine Learning · Computer Science 2023-10-17 Dennis Frauen , Valentyn Melnychuk , Stefan Feuerriegel

A mathematical model is identifiable if its parameters can be recovered from data. Here, we focus on a particular class of model, linear compartmental models, which are used to represent the transfer of substances in a system. We analyze…

Dynamical Systems · Mathematics 2021-06-22 Patrick Chan , Katherine Johnston , Anne Shiu , Aleksandra Sobieska , Clare Spinner

Structural causal models postulate noisy functional relations among a set of interacting variables. The causal structure underlying each such model is naturally represented by a directed graph whose edges indicate for each variable which…

Statistics Theory · Mathematics 2022-03-15 David Strieder , Tobias Freidling , Stefan Haffner , Mathias Drton

Finding the parameters of a latent variable causal model is central to causal inference and causal identification. In this article, we show that existing graphical structures that are used in causal inference are not stable under…

Machine Learning · Statistics 2025-10-03 Mehrzad Saremi

Many real-world decision-making tasks require learning causal relationships between a set of variables. Traditional causal discovery methods, however, require that all variables are observed, which is often not feasible in practical…

Methodology · Statistics 2023-06-27 Raj Agrawal , Chandler Squires , Neha Prasad , Caroline Uhler

In many problems, the measured variables (e.g., image pixels) are just mathematical functions of the latent causal variables (e.g., the underlying concepts or objects). For the purpose of making predictions in changing environments or…

Machine Learning · Computer Science 2024-08-13 Kun Zhang , Shaoan Xie , Ignavier Ng , Yujia Zheng

Exogenous heterogeneity, for example, in the form of instrumental variables can help us learn a system's underlying causal structure and predict the outcome of unseen intervention experiments. In this paper, we consider linear models in…

Methodology · Statistics 2024-10-21 Niklas Pfister , Jonas Peters

Discovering causal relationships from observational data is a challenging task that relies on assumptions connecting statistical quantities to graphical or algebraic causal models. In this work, we focus on widely employed assumptions for…

Methodology · Statistics 2024-03-20 Jonas Wahl , Urmi Ninad , Jakob Runge
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