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Parkinson's disease (PD) severity diagnosis is crucial for early detecting potential patients and adopting tailored interventions. Diagnosing PD based on facial expression is grounded in PD patients' "masked face" symptom and gains growing…

Computer Vision and Pattern Recognition · Computer Science 2025-10-22 Yintao Zhou , Wei Huang , Zhengyu Li , Jing Huang , Meng Pang

In non-invasive brain-computer interface systems, pre-movement decoding plays an important role in the detection of movement before limbs actually move. Movement-related cortical potential is a kind of brain activity associated with…

Human-Computer Interaction · Computer Science 2022-10-07 Hao Jia , Zhe Sun , Feng Duan , Yu Zhang , Cesar F. Caiafa , Jordi Solé-Casals

Parkinsons disease (PD) diagnosis is challenging due to subtle early clinical signs. F-DOPA PET is commonly used for early PD diagnosis. We explore the potential of machine-learning (ML) based EEG features extracted from single-channel EEG…

Neurons and Cognition · Quantitative Biology 2023-08-08 Lior Molcho , Neta B. Maimon , Neomi Hezi , Talya Zeimer , Nathan Intrator , Tanya Gurevich

In this paper, we evaluate the contribution of different handwriting modalities to the diagnosis of Parkinson's disease. We analyse on-surface movement, in-air movement and pressure exerted on the tablet surface. Especially in-air movement…

Signal Processing · Electrical Eng. & Systems 2022-03-23 Peter Drotár , Jiří Mekyska , Zdeněk Smékal , Irena Rektorová , Lucia Masarová , Marcos Faundez-Zanuy

Parkinson's Disease (PD) is the second most common neurodegenerative disease in humans. PD is characterized by the gradual loss of dopaminergic neurons in the Substantia Nigra (SN). Counting the number of dopaminergic neurons in the SN is…

Computer Vision and Pattern Recognition · Computer Science 2023-10-16 Fatemeh Haghighi , Soumitra Ghosh , Hai Ngu , Sarah Chu , Han Lin , Mohsen Hejrati , Baris Bingol , Somaye Hashemifar

Hyperkinetic movement disorders (HMDs) in children, including dystonia (abnormal twisting) and chorea (irregular, random movements), pose significant diagnostic challenges due to overlapping clinical features. The prevalence of dystonia…

Computer Vision and Pattern Recognition · Computer Science 2024-11-26 Nandika Ramamurthy , Dr Daniel Lumsden , Dr Rachel Sparks

We describe a statistical analysis of the eye tracker measurements in a database with 15 observers viewing 1003 images under free-viewing conditions. In contrast to the common approach of investigating the properties of the fixation points…

Computer Vision and Pattern Recognition · Computer Science 2014-06-25 Reiner Lenz

The rapid emergence of highly adaptable and reusable artificial intelligence (AI) models is set to revolutionize the medical field, particularly in the diagnosis and management of Parkinson's disease (PD). Currently, there are no effective…

Machine Learning · Computer Science 2025-02-18 Aite Zhao , Yongcan Liu , Xinglin Yu , Xinyue Xing

Deep learning has become increasingly important in remote sensing image classification due to its ability to extract semantic information from complex data. Classification tasks often include predefined label hierarchies that represent the…

Computer Vision and Pattern Recognition · Computer Science 2026-04-28 Giulio Weikmann , Gianmarco Perantoni , Lorenzo Bruzzone

Background: Positron Emission Tomography (PET) with 18F-fluorodeoxyglucose (18F-FDG) reveals metabolic abnormalities in Parkinson's disease (PD) at a systemic level. Previous metabolic connectome studies derived from groups of patients have…

Neurons and Cognition · Quantitative Biology 2021-05-07 Weikai Li , Yongxiang Tang , Zhengxia Wang , Shuo Hu , Xin Gao

Parkinson's disease (PD) shows heterogeneous, evolving brain-morphometry patterns. Modeling these longitudinal trajectories enables mechanistic insight, treatment development, and individualized 'digital-twin' forecasting. However, existing…

Machine Learning · Computer Science 2025-11-10 Xiaoda Wang , Yuji Zhao , Kaiqiao Han , Xiao Luo , Sanne van Rooij , Jennifer Stevens , Lifang He , Liang Zhan , Yizhou Sun , Wei Wang , Carl Yang

Isolated REM sleep behavior disorder (iRBD) is a key prodromal marker of Parkinson's disease (PD), and video-polysomnography (vPSG) remains the diagnostic gold standard. However, manual sleep staging is particularly challenging in…

In this work, the issue of Parkinson's disease (PD) diagnostics using non-invasive antemortem techniques was tackled. A deep learning approach for classification of raw speech recordings in patients with diagnosed PD was proposed. The core…

Computation and Language · Computer Science 2022-04-28 Maurycy Chronowski , Maciej Klaczynski , Malgorzata Dec-Cwiek , Karolina Porebska

Long-term monitoring of patients with epilepsy presents a challenging problem from the engineering perspective of real-time detection and wearable devices design. It requires new solutions that allow continuous unobstructed monitoring and…

Machine Learning · Computer Science 2022-04-11 Una Pale , Tomas Teijeiro , David Atienza

One of the most prevalent complaints of individuals with mid-stage and advanced Parkinson's disease (PD) is the fluctuating response to their medication (i.e., ON state with maximum benefit from medication and OFF state with no benefit from…

Computer Vision and Pattern Recognition · Computer Science 2018-09-20 Murtadha D. Hssayeni , Michelle A. Burack , M. D. , Joohi Jimenez-Shahed , M. D. , Behnaz Ghoraani , Ph. D

The detection of weak, spatially distributed anomalies in volumetric medical imaging remains challenging due to the difficulty of integrating subtle signals across non-adjacent regions. This study presents a controlled comparison of sixteen…

Computer Vision and Pattern Recognition · Computer Science 2025-12-12 Lynn Kandakji , William Woof , Nikolas Pontikos

Video-based assessments offer a scalable pathway for remote Parkinson's disease (PD) screening. While traditional approaches rely on handcrafted features mimicking clinical scales, recent advances in video foundation models (VFMs) enable…

Early and accurate detection of Parkinson's disease (PD) remains a critical challenge in medical diagnostics due to the subtlety of early-stage symptoms and the complex, non-linear relationships inherent in biomedical data. Traditional…

Machine Learning · Computer Science 2026-02-10 Olamide Samuel Oseni , Ibraheem Omotolani Obanla , Toheeb Aduramomi Jimoh

Speech impairments in Parkinson's disease (PD) provide significant early indicators for diagnosis. While models for speech-based PD detection have shown strong performance, their interpretability remains underexplored. This study…

Sound · Computer Science 2024-11-14 Eleonora Mancini , Francesco Paissan , Paolo Torroni , Mirco Ravanelli , Cem Subakan

Perception-related errors comprise most diagnostic mistakes in radiology. To mitigate this problem, radiologists employ personalized and high-dimensional visual search strategies, otherwise known as search patterns. Qualitative descriptions…