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In this paper, we present the Directly Denoising Diffusion Model (DDDM): a simple and generic approach for generating realistic images with few-step sampling, while multistep sampling is still preserved for better performance. DDDMs require…

Computer Vision and Pattern Recognition · Computer Science 2024-06-03 Dan Zhang , Jingjing Wang , Feng Luo

Early detection of myometrial invasion is critical for the staging and life-saving management of endometrial carcinoma (EC), a prevalent global malignancy. Transvaginal ultrasound serves as the primary, accessible screening modality in…

Computer Vision and Pattern Recognition · Computer Science 2026-02-24 Dongjing Shan , Yamei Luo , Jiqing Xuan , Lu Huang , Jin Li , Mengchu Yang , Zeyu Chen , Fajin Lv , Yong Tang , Chunxiang Zhang

Skin diseases, such as skin cancer, are a significant public health issue, and early diagnosis is crucial for effective treatment. Artificial intelligence (AI) algorithms have the potential to assist in triaging benign vs malignant skin…

Computer Vision and Pattern Recognition · Computer Science 2025-03-25 Nusrat Munia , Abdullah-Al-Zubaer Imran

Infrared imagery enables temperature-based scene understanding using passive sensors, particularly under conditions of low visibility where traditional RGB imaging fails. Yet, developing downstream vision models for infrared applications is…

Computer Vision and Pattern Recognition · Computer Science 2025-11-11 Kai A. Horstmann , Maxim Clouser , Kia Khezeli

Distilling demonstration effects into hidden-space interventions offers a lightweight alternative to full finetuning. However, existing multimodal variants are mostly evaluated on short-form tasks, where outputs end after a few tokens.…

Computation and Language · Computer Science 2026-05-27 Ning Wu , Rui Liu , Xinkun Lin , Weixing Chen , Jinxi Xiang , Tao Wei , Lina Yao , Mingjie Li

Distribution Matching Distillation (DMD) is a promising score distillation technique that compresses pre-trained teacher diffusion models into efficient one-step or multi-step student generators. Nevertheless, its reliance on the reverse…

Computer Vision and Pattern Recognition · Computer Science 2025-07-25 Yanzuo Lu , Yuxi Ren , Xin Xia , Shanchuan Lin , Xing Wang , Xuefeng Xiao , Andy J. Ma , Xiaohua Xie , Jian-Huang Lai

Diffusion models have shown remarkable progress in various generative tasks such as image and video generation. This paper studies the problem of leveraging pretrained diffusion models for performing discriminative tasks. Specifically, we…

Computer Vision and Pattern Recognition · Computer Science 2025-04-25 Yinqi Li , Hong Chang , Ruibing Hou , Shiguang Shan , Xilin Chen

Weakly Supervised Semantic Segmentation (WSSS) with image-level labels typically leverages Class Activation Maps (CAMs) to achieve pixel-level predictions. Recently, Contrastive Language-Image Pre-training (CLIP) has been introduced to…

Computer Vision and Pattern Recognition · Computer Science 2026-05-07 Zhiwei Yang , Pengfei Song , Yucong Meng , Kexue Fu , Shuo Wang , Zhijian Song

Recent emergence of high-throughput drug screening assays sparkled an intensive development of machine learning methods, including models for prediction of sensitivity of cancer cell lines to anti-cancer drugs, as well as methods for…

Machine Learning · Computer Science 2022-06-09 Krzysztof Koras , Marcin Możejko , Paulina Szymczak , Eike Staub , Ewa Szczurek

Image anomaly detection plays a vital role in applications such as industrial quality inspection and medical imaging, where it directly contributes to improving product quality and system reliability. However, existing methods often…

Computer Vision and Pattern Recognition · Computer Science 2025-09-24 Zekang Weng , Jinjin Shi , Jinwei Wang , Zeming Han

Multiple instance learning (MIL) is a powerful approach to classify whole slide images (WSIs) for diagnostic pathology. A fundamental challenge of MIL on WSI classification is to discover the \textit{critical instances} that trigger the bag…

Computer Vision and Pattern Recognition · Computer Science 2022-09-02 Zhikang Wang , Yue Bi , Tong Pan , Xiaoyu Wang , Chris Bain , Richard Bassed , Seiya Imoto , Jianhua Yao , Jiangning Song

As the global HIV pandemic enters its fourth decade, increasing numbers of surveillance sites have been established which allows countries to look into the epidemics at a finer scale, e.g. at sub-national levels. Currently, the epidemic…

Applications · Statistics 2015-08-27 Le Bao , Xiaoyue Niu , Mary Mahy , Peter D. Ghys

Diffusion distillation is a widely used technique to reduce the sampling cost of diffusion models, yet it often requires extensive training, and the student performance tends to be degraded. Recent studies show that incorporating a GAN…

Machine Learning · Computer Science 2025-06-12 Bowen Zheng , Tianming Yang

Generative diffusion models, famous for their performance in image generation, are popular in various cross-domain applications. However, their use in the communication community has been mostly limited to auxiliary tasks like data modeling…

Networking and Internet Architecture · Computer Science 2025-03-11 Ruihuai Liang , Bo Yang , Zhiwen Yu , Bin Guo , Xuelin Cao , Mérouane Debbah , H. Vincent Poor , Chau Yuen

We analyze 14,651 HIV1 reverse transcriptase (HIV RT) sequences from the Stanford HIV Drug Resistance Database labeled with treatment regimen in order to study the evolution this enzyme under drug selection in the clinic. Our goal is to…

Genomics · Quantitative Biology 2022-10-04 Shefali Qamar , Manel Camps , Jay Kim

Molecular conformation generation plays key roles in computational drug design. Recently developed deep learning methods, particularly diffusion models have reached competitive performance over traditional cheminformatical approaches.…

Machine Learning · Computer Science 2025-01-10 Yixuan Yang , Xingyu Fang , Zhaowen Cheng , Pengju Yan , Xiaolin Li

With a 676% growth rate in HIV incidence between 2010 and 2021, the HIV/AIDS epidemic in the Philippines is the one that is spreading the quickest in the western Pacific. Although the full effects of COVID-19 on HIV services and development…

Neural and Evolutionary Computing · Computer Science 2024-01-12 Sales G. Aribe , Bobby D. Gerardo , Ruji P. Medina

Scientific expertise often requires recognizing subtle visual differences that remain challenging to articulate even for domain experts. We present a system that leverages generative models to automatically discover and visualize minimal…

Computer Vision and Pattern Recognition · Computer Science 2025-05-16 Mia Chiquier , Orr Avrech , Yossi Gandelsman , Berthy Feng , Katherine Bouman , Carl Vondrick

The intersection of artificial intelligence and bioinformatics has enabled significant advancements in drug discovery, particularly through the application of machine learning models. In this study, we present a combined approach using…

Biomolecules · Quantitative Biology 2024-08-15 Ricardo Romero

Generative models are increasingly used to augment medical imaging datasets for fairer AI. Yet a key assumption often goes unexamined: that generators themselves produce equally high-quality images across demographic groups. Models trained…

Computer Vision and Pattern Recognition · Computer Science 2026-03-18 Mahmoud Ibrahim , Bart Elen , Chang Sun , Gokhan Ertaylan , Michel Dumontier