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Conventional cardiovascular magnetic resonance (CMR) cine imaging relies on binning multiple heartbeats into a single cardiac cycle, which fails in arrhythmic patients where beat-to-beat variability causes motion artifacts and loss of…
An Electroencephalogram (EEG) is a non-invasive exam that records the brain's electrical activity. This is used to help diagnose conditions such as different brain problems. EEG signals are taken for epilepsy detection, and with Discrete…
Cardiac disease evaluation depends on multiple diagnostic modalities: electrocardiogram (ECG) to diagnose abnormal heart rhythms, and imaging modalities such as Magnetic Resonance Imaging (MRI), Computed Tomography (CT) and echocardiography…
Left ventricular ejection fraction (LVEF) is a key indicator of cardiac function and plays a central role in the diagnosis and management of cardiovascular disease. Echocardiography, as a readily accessible and non-invasive imaging…
We report three-dimensional and time-dependent numerical simulations of the propagation of electrical action potentials in a model of rabbit ventricular tissue. The simulations are performed using a finite-element method for the solution of…
Cardiac arrhythmias such as ventricular tachycardia (VT) or ventricular fibrillation (VF) are the leading cause of death in the industrialised world. There is a growing consensus that these arrhythmias arise because of the formation of…
INTRODUCTION: Lateral ventricles are reliable and sensitive indicators of brain atrophy and disease progression in behavioral variant frontotemporal dementia (bvFTD). We aimed to investigate whether an automated tool using ventricular…
One of the challenges in the development of patient-specific models of cardiac arrhythmias for clinical applications has been accounting for myocardial fiber organization. The fiber varies significantly from heart to heart, but cannot be…
Diffusion Tensor Cardiac Magnetic Resonance (DT-CMR) is the only in vivo method to non-invasively examine the microstructure of the human heart. Current research in DT-CMR aims to improve the understanding of how the cardiac microstructure…
Myocardial Velocity Mapping Cardiac MR (MVM-CMR) can be used to measure global and regional myocardial velocities with proved reproducibility. Accurate left ventricle delineation is a prerequisite for robust and reproducible myocardial…
Ventricular arrhythmias comprise a group of disorders which manifest clinically in a variety of ways from ventricular premature beats (VPB) and no sustained ventricular tachycardia (in healthy subjects) to sudden cardiac death due to…
Purpose: Bioprosthetic Heart Valves (BHVs) are currently in widespread use with promising outcomes. Computational modeling provides a framework for quantitatively describing BHVs in the preclinical phase. To obtain reliable solutions in…
Myocardial Contrast Echocardiography (MCE) with micro-bubble contrast agent enables myocardial perfusion quantification which is invaluable for the early detection of coronary artery diseases. In this paper, we proposed a new segmentation…
Accurate segmentation and motion estimation of myocardium have always been important in clinic field, which essentially contribute to the downstream diagnosis. However, existing methods cannot always guarantee the shape integrity for…
Atherosclerosis, a chronic inflammatory disease affecting the large arteries, presents a global health risk. Accurate analysis of diagnostic images, like computed tomographic angiograms (CTAs), is essential for staging and monitoring the…
Cardiac parametric mapping is useful for evaluating cardiac fibrosis and edema. Parametric mapping relies on single-shot heartbeat-by-heartbeat imaging, which is susceptible to intra-shot motion during the imaging window. However, reducing…
A major challenge in computational models of cardiac electromechanics is the reconstruction of myocardial fiber architecture, as direct in vivo measurements of fiber orientation are not feasible. Consequently, rule-based methods are…
The left ventricular of ejection fraction is one of the most important metric of cardiac function. It is used by cardiologist to identify patients who are eligible for lifeprolonging therapies. However, the assessment of ejection fraction…
The cardiologist's main tool for measuring systolic heart failure is left ventricular ejection fraction (LVEF). Trained cardiologist's report both a visual and machine-guided measurement of LVEF, but only use this machine-guided measurement…
The human heart is enclosed in the pericardial cavity. The pericardium consists of a layered thin sac and is separated from the myocardium by a thin film of fluid. It provides a fixture in space and frictionless sliding of the myocardium.…