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Large language models (LLMs) are transforming cellular biology by enabling the development of "virtual cells"--computational systems that represent, predict, and reason about cellular states and behaviors. This work provides a comprehensive…

Computation and Language · Computer Science 2025-10-10 Krinos Li , Xianglu Xiao , Shenglong Deng , Lucas He , Zijun Zhong , Yuanjie Zou , Zhonghao Zhan , Zheng Hui , Weiye Bao , Guang Yang

As enthusiasm for scaling computation (data and parameters) in the pretraining era gradually diminished, test-time scaling (TTS), also referred to as ``test-time computing'' has emerged as a prominent research focus. Recent studies…

Computation and Language · Computer Science 2025-05-06 Qiyuan Zhang , Fuyuan Lyu , Zexu Sun , Lei Wang , Weixu Zhang , Wenyue Hua , Haolun Wu , Zhihan Guo , Yufei Wang , Niklas Muennighoff , Irwin King , Xue Liu , Chen Ma

Personalization of Large Language Models (LLMs) has recently become increasingly important with a wide range of applications. Despite the importance and recent progress, most existing works on personalized LLMs have focused either entirely…

In this paper, we describe the capabilities and constraints of Large Language Models (LLMs) within disparate academic disciplines, aiming to delineate their strengths and limitations with precision. We examine how LLMs augment scientific…

Recently, Large Language Models (LLM) have demonstrated impressive capability to solve a wide range of tasks. However, despite their success across various tasks, no prior work has investigated their capability in the biomedical domain yet.…

Computation and Language · Computer Science 2024-02-21 Israt Jahan , Md Tahmid Rahman Laskar , Chun Peng , Jimmy Huang

Connecting text and visual modalities plays an essential role in generative intelligence. For this reason, inspired by the success of large language models, significant research efforts are being devoted to the development of Multimodal…

Computer Vision and Pattern Recognition · Computer Science 2024-06-07 Davide Caffagni , Federico Cocchi , Luca Barsellotti , Nicholas Moratelli , Sara Sarto , Lorenzo Baraldi , Lorenzo Baraldi , Marcella Cornia , Rita Cucchiara

Pre-trained large language models (LLM) have emerged as a powerful tool for simulating various scenarios and generating output given specific instructions and multimodal input. In this work, we analyze the specific use of LLM to enhance a…

Machine Learning · Computer Science 2024-05-10 Yuhang Wu , Yingfei Wang , Chu Wang , Zeyu Zheng

Recent years have witnessed remarkable progress made in large language models (LLMs). Such advancements, while garnering significant attention, have concurrently elicited various concerns. The potential of these models is undeniably vast;…

Computation and Language · Computer Science 2023-09-27 Tianhao Shen , Renren Jin , Yufei Huang , Chuang Liu , Weilong Dong , Zishan Guo , Xinwei Wu , Yan Liu , Deyi Xiong

In the domain of data science, the predictive tasks of classification, regression, and imputation of missing values are commonly encountered challenges associated with tabular data. This research endeavors to apply Large Language Models…

Machine Learning · Computer Science 2026-04-23 Yazheng Yang , Yuqi Wang , Yaxuan Li , Sankalok Sen , Lei Li , Lin Qiu , Qi Liu

This paper provides a comprehensive review of the current methods and metrics used to evaluate the performance of Large Language Models (LLMs) in code generation tasks. With the rapid growth in demand for automated software development,…

Software Engineering · Computer Science 2025-03-05 Liguo Chen , Qi Guo , Hongrui Jia , Zhengran Zeng , Xin Wang , Yijiang Xu , Jian Wu , Yidong Wang , Qing Gao , Jindong Wang , Wei Ye , Shikun Zhang

This paper explores the potential of using Large Language Models (LLMs) to automate the evaluation of responses in medical Question and Answer (Q\&A) systems, a crucial form of Natural Language Processing. Traditionally, human evaluation…

Computation and Language · Computer Science 2024-09-04 Jack Krolik , Herprit Mahal , Feroz Ahmad , Gaurav Trivedi , Bahador Saket

Large Language Models (LLMs), originally developed for natural language processing (NLP), have demonstrated the potential to generalize across modalities and domains. With their in-context learning (ICL) capabilities, LLMs can perform…

Artificial Intelligence · Computer Science 2025-08-26 Nikolaos Pavlidis , Vasilis Perifanis , Symeon Symeonidis , Pavlos S. Efraimidis

Large Language Model (LLM) techniques play an increasingly important role in Natural Language to SQL (NL2SQL) translation. LLMs trained by extensive corpora have strong natural language understanding and basic SQL generation abilities…

Databases · Computer Science 2024-04-01 Tonghui Ren , Yuankai Fan , Zhenying He , Ren Huang , Jiaqi Dai , Can Huang , Yinan Jing , Kai Zhang , Yifan Yang , X. Sean Wang

This paper presents a comprehensive evaluation of cost-efficient Large Language Models (LLMs) for diverse biomedical tasks spanning both text and image modalities. We evaluated a range of closed-source and open-source LLMs on tasks such as…

Computation and Language · Computer Science 2025-07-21 Israt Jahan , Md Tahmid Rahman Laskar , Chun Peng , Jimmy Huang

In the past year, MultiModal Large Language Models (MM-LLMs) have undergone substantial advancements, augmenting off-the-shelf LLMs to support MM inputs or outputs via cost-effective training strategies. The resulting models not only…

Computation and Language · Computer Science 2024-05-29 Duzhen Zhang , Yahan Yu , Jiahua Dong , Chenxing Li , Dan Su , Chenhui Chu , Dong Yu

The rapid advancement of Large Language Models (LLMs) has driven novel applications across diverse domains, with LLM-based agents emerging as a crucial area of exploration. This survey presents a comprehensive analysis of LLM-based agents…

Artificial Intelligence · Computer Science 2025-11-25 Ke Chen , Peiran Wang , Yaoning Yu , Xianyang Zhan , Haohan Wang

Large language models (LLMs) are being increasingly integrated into legal applications, including judicial decision support, legal practice assistance, and public-facing legal services. While LLMs show strong potential in handling legal…

This paper provides a comprehensive survey of the latest research on multilingual large language models (MLLMs). MLLMs not only are able to understand and generate language across linguistic boundaries, but also represent an important…

Computation and Language · Computer Science 2024-11-20 Shaolin Zhu , Supryadi , Shaoyang Xu , Haoran Sun , Leiyu Pan , Menglong Cui , Jiangcun Du , Renren Jin , António Branco , Deyi Xiong

Natural Language Processing (NLP) is witnessing a remarkable breakthrough driven by the success of Large Language Models (LLMs). LLMs have gained significant attention across academia and industry for their versatile applications in text…

Computation and Language · Computer Science 2024-04-16 Taojun Hu , Xiao-Hua Zhou

Text-to-SQL is a subtask in semantic parsing that has seen rapid progress with the evolution of Large Language Models (LLMs). However, LLMs face challenges due to hallucination issues and a lack of domain-specific database knowledge(such as…

Computation and Language · Computer Science 2025-02-26 Xingyu Ma , Xin Tian , Lingxiang Wu , Xuepeng Wang , Xueming Tang , Jinqiao Wang