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In this thesis, we present robust and fully-automated methods for the subdivision of the entire human cerebral cortex based on connectivity information. Our contributions are four-fold: First, we propose a clustering approach to delineate a…

Neurons and Cognition · Quantitative Biology 2018-02-21 Salim Arslan

One of the primary objectives of human brain mapping is the division of the cortical surface into functionally distinct regions, i.e. parcellation. While it is generally agreed that at macro-scale different regions of the cortex have…

Neurons and Cognition · Quantitative Biology 2017-03-06 Daniel Moyer , Boris A Gutman , Neda Jahanshad , Paul M. Thompson

The parcellation of Cranial Nerves (CNs) serves as a crucial quantitative methodology for evaluating the morphological characteristics and anatomical pathways of specific CNs. Multi-modal CNs parcellation networks have achieved promising…

Image and Video Processing · Electrical Eng. & Systems 2025-08-05 Lei Xie , Junxiong Huang , Yuanjing Feng , Qingrun Zeng

Tractography fiber clustering using diffusion MRI (dMRI) is a crucial method for white matter (WM) parcellation to enable analysis of brains structural connectivity in health and disease. Current fiber clustering strategies primarily use…

Image and Video Processing · Electrical Eng. & Systems 2025-11-04 Bocheng Guo , Jin Wang , Yijie Li , Junyi Wang , Mingyu Gao , Puming Feng , Yuqian Chen , Jarrett Rushmore , Nikos Makris , Yogesh Rathi , Lauren J O'Donnell , Fan Zhang

Brain nuclei are clusters of anatomically distinct neurons that serve as important hubs for processing and relaying information in various neural circuits. Fine-scale parcellation of the brain nuclei is vital for a comprehensive…

Image and Video Processing · Electrical Eng. & Systems 2025-09-03 Haolin He , Ce Zhu , Le Zhang , Yipeng Liu , Xiao Xu , Yuqian Chen , Leo Zekelman , Jarrett Rushmore , Yogesh Rathi , Nikos Makris , Lauren J. O'Donnell , Fan Zhang

The amygdala plays a vital role in emotional processing and exhibits structural diversity that necessitates fine-scale parcellation for a comprehensive understanding of its anatomico-functional correlations. Diffusion MRI tractography is an…

Image and Video Processing · Electrical Eng. & Systems 2023-11-28 Haolin He , Ce Zhu , Le Zhang , Yipeng Liu , Xiao Xu , Yuqian Chen , Leo Zekelman , Jarrett Rushmore , Yogesh Rathi , Nikos Makris , Lauren J. O'Donnell , Fan Zhang

Tractography fiber clustering using diffusion MRI (dMRI) is a crucial strategy for white matter (WM) parcellation. Current methods primarily use the geometric information of fibers (i.e., the spatial trajectories) to group similar fibers…

Image and Video Processing · Electrical Eng. & Systems 2024-12-17 Jin Wang , Bocheng Guo , Yijie Li , Junyi Wang , Yuqian Chen , Jarrett Rushmore , Nikos Makris , Yogesh Rathi , Lauren J O'Donnell , Fan Zhang

Parcellation of whole-brain tractography streamlines is an important step for tract-based analysis of brain white matter microstructure. Existing fiber parcellation approaches rely on accurate registration between an atlas and the…

Image and Video Processing · Electrical Eng. & Systems 2019-12-24 Feihong Liu , Jun Feng , Geng Chen , Ye Wu , Yoonmi Hong , Pew-Thian Yap , Dinggang Shen

Brain parcellations play a ubiquitous role in the analysis of magnetic resonance imaging (MRI) datasets. Over 100 years of research has been conducted in pursuit of an ideal brain parcellation. Different methods have been developed and…

Neurons and Cognition · Quantitative Biology 2021-07-09 Pantea Moghimi , Anh The Dang , Theoden I. Netoff , Kelvin O. Lim , Gowtham Atluri

We present cortical surface parcellation using spherical deep convolutional neural networks. Traditional multi-atlas cortical surface parcellation requires inter-subject surface registration using geometric features with high processing…

Diffusion MRI (dMRI) tractography enables in vivo mapping of brain structural connections, but traditional connectome generation is time-consuming and requires gray matter parcellation, posing challenges for large-scale studies. We…

Image and Video Processing · Electrical Eng. & Systems 2025-06-12 Marcus J. Vroemen , Yuqian Chen , Yui Lo , Tengfei Xue , Weidong Cai , Fan Zhang , Josien P. W. Pluim , Lauren J. O'Donnell

Current theories hold that brain function is highly related to long-range physical connections through axonal bundles, namely extrinsic connectiv-ity. However, obtaining a groupwise cortical parcellation based on extrinsic connectivity…

Applications · Statistics 2017-01-06 Guillermo Gallardo , William Wells , Rachid Deriche , Demian Wassermann

About 5-8% of individuals over the age of 60 have dementia. With our ever-aging population this number is likely to increase, making dementia one of the most important threats to public health in the 21st century. Given the phenotypic…

Image and Video Processing · Electrical Eng. & Systems 2021-02-16 Magnus Magnusson , Askell Love , Lotta M. Ellingsen

We present a hybrid method that performs the complete parcellation of the cerebral cortex of an individual, based on the connectivity information of the white matter fibers from a whole-brain tractography dataset. The method consists of…

Neurons and Cognition · Quantitative Biology 2020-02-24 Narciso López-López , Andrea Vázquez , Cyril Poupon , Jean-François Mangin , Pamela Guevara

Accurate brain parcellation in diffusion MRI (dMRI) space is essential for advanced neuroimaging analyses. However, most existing approaches rely on anatomical MRI for segmentation and inter-modality registration, a process that can…

Image and Video Processing · Electrical Eng. & Systems 2025-08-12 Yousef Sadegheih , Dorit Merhof

The majority of existing human parsing methods formulate the task as semantic segmentation, which regard each semantic category equally and fail to exploit the intrinsic physiological structure of human body, resulting in inaccurate…

Computer Vision and Pattern Recognition · Computer Science 2019-12-23 Ruyi Ji , Dawei Du , Libo Zhang , Longyin Wen , Yanjun Wu , Chen Zhao , Feiyue Huang , Siwei Lyu

An essential premise for neuroscience brain network analysis is the successful segmentation of the cerebral cortex into functionally homogeneous regions. Resting-state functional magnetic resonance imaging (rs-fMRI), capturing the…

Neurons and Cognition · Quantitative Biology 2023-09-20 Xiaoxiao Ma , Chunzhi Yi , Zhicai Zhong , Hui Zhou , Baichun Wei , Haiqi Zhu , Feng Jiang

Deep convolutional neural networks are powerful tools for learning visual representations from images. However, designing efficient deep architectures to analyse volumetric medical images remains challenging. This work investigates…

Computer Vision and Pattern Recognition · Computer Science 2017-07-10 Wenqi Li , Guotai Wang , Lucas Fidon , Sebastien Ourselin , M. Jorge Cardoso , Tom Vercauteren

As the largest human cerebellar nucleus, the dentate nucleus (DN) functions significantly in the communication between the cerebellum and the rest of the brain. Structural connectivity-based parcellation has the potential to reveal the…

Image and Video Processing · Electrical Eng. & Systems 2023-01-23 Xiao Xu , Yuqian Chen , Leo Zekelman , Yogesh Rathi , Nikos Makris , Fan Zhang , Lauren J. O'Donnell

Multimodal MRI offers complementary multi-scale information to characterize the brain structure. However, it remains challenging to effectively integrate multimodal MRI while achieving neuroscience interpretability. Here we propose to use…

Neurons and Cognition · Quantitative Biology 2025-12-15 Chengzhi Xia , Jianwei Chen , Yixuan Jiang , Qi Yan , Chao Li
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