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Diffusion-based generative models (DBGMs) perturb data to a target noise distribution and reverse this process to generate samples. The choice of noising process, or inference diffusion process, affects both likelihoods and sample quality.…

Machine Learning · Computer Science 2023-03-06 Raghav Singhal , Mark Goldstein , Rajesh Ranganath

Denoising Diffusion Models (DDMs) have become a popular tool for generating high-quality samples from complex data distributions. These models are able to capture sophisticated patterns and structures in the data, and can generate samples…

Computer Vision and Pattern Recognition · Computer Science 2024-08-20 Emanuele Aiello , Diego Valsesia , Enrico Magli

Diffusion models have achieved significant success in both natural image and medical image domains, encompassing a wide range of applications. Previous investigations in medical images have often been constrained to specific anatomical…

Computer Vision and Pattern Recognition · Computer Science 2025-12-08 Yongrui Yu , Yannian Gu , Shaoting Zhang , Xiaofan Zhang

Background: Photoacoustic Microscopy (PAM) integrates optical and acoustic imaging, offering enhanced penetration depth for detecting optical-absorbing components in tissues. Nonetheless, challenges arise in scanning large areas with high…

Medical Physics · Physics 2023-12-15 Irem Loc , Mehmet Burcin Unlu

Image anomaly detection plays a vital role in applications such as industrial quality inspection and medical imaging, where it directly contributes to improving product quality and system reliability. However, existing methods often…

Computer Vision and Pattern Recognition · Computer Science 2025-09-24 Zekang Weng , Jinjin Shi , Jinwei Wang , Zeming Han

Many self-supervised denoising approaches have been proposed in recent years. However, these methods tend to overly smooth images, resulting in the loss of fine structures that are essential for medical applications. In this paper, we…

Image and Video Processing · Electrical Eng. & Systems 2025-04-02 Basar Demir , Yikang Liu , Xiao Chen , Eric Z. Chen , Lin Zhao , Boris Mailhe , Terrence Chen , Shanhui Sun

Accurate detection and segmentation of brain tumors in magnetic resonance imaging (MRI) are critical for effective diagnosis and treatment planning. Despite advances in convolutional neural networks (CNNs) such as U-Net, existing models…

Computer Vision and Pattern Recognition · Computer Science 2025-10-14 Sashank Makanaboyina

Quality assessment of prenatal ultrasonography is essential for the screening of fetal central nervous system (CNS) anomalies. The interpretation of fetal brain structures is highly subjective, expertise-driven, and requires years of…

As data continues to grow in volume and complexity across domains such as finance, manufacturing, and healthcare, effective anomaly detection is essential for identifying irregular patterns that may signal critical issues. Recently,…

Machine Learning · Computer Science 2025-06-16 Jing Ren , Tao Tang , Hong Jia , Ziqi Xu , Haytham Fayek , Xiaodong Li , Suyu Ma , Xiwei Xu , Feng Xia

Unsupervised anomaly detection methods offer a promising and flexible alternative to supervised approaches, holding the potential to revolutionize medical scan analysis and enhance diagnostic performance. In the current landscape, it is…

Image and Video Processing · Electrical Eng. & Systems 2023-08-29 Cosmin I. Bercea , Esther Puyol-Antón , Benedikt Wiestler , Daniel Rueckert , Julia A. Schnabel , Andrew P. King

Out-of-distribution (OOD) detection is crucial for the safety and reliability of artificial intelligence algorithms, especially in the medical domain. In the context of the Medical OOD (MOOD) detection challenge 2023, we propose a pipeline…

Computer Vision and Pattern Recognition · Computer Science 2023-10-16 Evi M. C. Huijben , Sina Amirrajab , Josien P. W. Pluim

Prenatal ultrasound is the cornerstone for detecting congenital anomalies of the kidneys and urinary tract, but diagnosis is limited by operator dependence and suboptimal imaging conditions. We sought to assess the performance of a…

Image and Video Processing · Electrical Eng. & Systems 2025-12-16 Youssef Megahed , Inok Lee , Robin Ducharme , Kevin Dick , Adrian D. C. Chan , Steven Hawken , Mark C. Walker

Automatic detecting anomalous regions in images of objects or textures without priors of the anomalies is challenging, especially when the anomalies appear in very small areas of the images, making difficult-to-detect visual variations,…

Computer Vision and Pattern Recognition · Computer Science 2022-07-05 Jie Yang , Yong Shi , Zhiquan Qi

The advent of handheld fundus imaging devices has made ophthalmologic diagnosis and disease screening more accessible, efficient, and cost-effective. However, images captured from these setups often suffer from artifacts such as flash…

Computer Vision and Pattern Recognition · Computer Science 2026-04-20 Mathumetha Palani , Kavya Puthumana , Ayantika Das , Ganapathy Krishnamurthi

Deep unsupervised representation learning has recently led to new approaches in the field of Unsupervised Anomaly Detection (UAD) in brain MRI. The main principle behind these works is to learn a model of normal anatomy by learning to…

Image and Video Processing · Electrical Eng. & Systems 2020-04-09 Christoph Baur , Stefan Denner , Benedikt Wiestler , Shadi Albarqouni , Nassir Navab

Traditional reconstruction-based methods have struggled to achieve competitive performance in anomaly detection. In this paper, we introduce Denoising Diffusion Anomaly Detection (DDAD), a novel denoising process for image reconstruction…

Computer Vision and Pattern Recognition · Computer Science 2025-04-29 Arian Mousakhan , Thomas Brox , Jawad Tayyub

The detection and the quantification of anomalies in image data are critical tasks in industrial scenes such as detecting micro scratches on product. In recent years, due to the difficulty of defining anomalies and the limit of correcting…

Computer Vision and Pattern Recognition · Computer Science 2018-11-08 Masanari Kimura , Takashi Yanagihara

In this paper, we study the denoising diffusion probabilistic model (DDPM) in wavelet space, instead of pixel space, for visual synthesis. Considering the wavelet transform represents the image in spatial and frequency domains, we carefully…

Computer Vision and Pattern Recognition · Computer Science 2023-07-28 Xin Yuan , Linjie Li , Jianfeng Wang , Zhengyuan Yang , Kevin Lin , Zicheng Liu , Lijuan Wang

Diffusion models are state-of-the-art generative models on data modalities such as images, audio, proteins and materials. These modalities share the property of exponentially decaying variance and magnitude in the Fourier domain. Under the…

Image reconstruction from radio-frequency data is pivotal in ultrafast plane wave ultrasound imaging. Unlike the conventional delay-and-sum (DAS) technique, which relies on somewhat imprecise assumptions, deep learning-based methods perform…

Computer Vision and Pattern Recognition · Computer Science 2023-12-18 Hengrong Lan , Zhiqiang Li , Qiong He , Jianwen Luo