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Causal discovery is an imperative foundation for decision-making across domains, such as smart health, AI for drug discovery and AIOps. Traditional statistical causal discovery methods, while well-established, predominantly rely on…

Machine Learning · Computer Science 2025-06-03 ChengAo Shen , Zhengzhang Chen , Dongsheng Luo , Dongkuan Xu , Haifeng Chen , Jingchao Ni

Uncovering cause-and-effect mechanisms from data is fundamental to scientific progress. While large language models (LLMs) show promise for enhancing causal discovery (CD) from unstructured data, their application to the increasingly…

Machine Learning · Computer Science 2025-10-31 Jin Li , Shoujin Wang , Qi Zhang , Feng Liu , Tongliang Liu , Longbing Cao , Shui Yu , Fang Chen

Causal discovery (CD) and Large Language Models (LLMs) have emerged as transformative fields in artificial intelligence that have evolved largely independently. While CD specializes in uncovering cause-effect relationships from data, and…

Computation and Language · Computer Science 2025-02-18 Guangya Wan , Yunsheng Lu , Yuqi Wu , Mengxuan Hu , Sheng Li

We present DMCD (DataMap Causal Discovery), a two-phase causal discovery framework that integrates LLM-based semantic drafting from variable metadata with statistical validation on observational data. In Phase I, a large language model…

Artificial Intelligence · Computer Science 2026-02-25 Samarth KaPatel , Sofia Nikiforova , Giacinto Paolo Saggese , Paul Smith

Estimating individualized treatment effects from observational data presents a persistent challenge due to unmeasured confounding and structural bias. Causal Machine Learning (causal ML) methods, such as causal trees and doubly robust…

Machine Learning · Computer Science 2025-08-12 Po-Han Lee , Yu-Cheng Lin , Chan-Tung Ku , Chan Hsu , Pei-Cing Huang , Ping-Hsun Wu , Yihuang Kang

Large language models (LLMs) have demonstrated notable potential in medical applications, yet they face substantial challenges in handling complex real-world clinical diagnoses using conventional prompting methods. Current prompt…

Artificial Intelligence · Computer Science 2026-03-02 Wenliang Li , Rui Yan , Xu Zhang , Li Chen , Hongji Zhu , Jing Zhao , Junjun Li , Mengru Li , Wei Cao , Zihang Jiang , Wei Wei , Kun Zhang , Shaohua Kevin Zhou

Large Language Models (LLMs) have demonstrated remarkable capabilities in various reasoning and generation tasks. However, their proficiency in complex causal reasoning, discovery, and estimation remains an area of active development, often…

Artificial Intelligence · Computer Science 2025-09-03 Adib Bazgir , Amir Habibdoust , Yuwen Zhang , Xing Song

Causal discovery (CD) plays a pivotal role in numerous scientific fields by clarifying the causal relationships that underlie phenomena observed in diverse disciplines. Despite significant advancements in CD algorithms that enhance bias and…

Machine Learning · Computer Science 2025-03-25 Khadija Zanna , Akane Sano

Causal discovery seeks to uncover causal relations from data, typically represented as causal graphs, and is essential for predicting the effects of interventions. While expert knowledge is required to construct principled causal graphs,…

Artificial Intelligence · Computer Science 2026-02-19 Zihao Li , Fabrizio Russo

Recovering the structure of causal graphical models from observational data is an essential yet challenging task for causal discovery in scientific scenarios. Domain-specific causal discovery usually relies on expert validation or prior…

Artificial Intelligence · Computer Science 2025-08-27 Taiyu Ban , Lyuzhou Chen , Derui Lyu , Xiangyu Wang , Qinrui Zhu , Qiang Tu , Huanhuan Chen

Causal graph recovery is traditionally done using statistical estimation-based methods or based on individual's knowledge about variables of interests. They often suffer from data collection biases and limitations of individuals' knowledge.…

Computation and Language · Computer Science 2024-06-19 Yuzhe Zhang , Yipeng Zhang , Yidong Gan , Lina Yao , Chen Wang

Large language models (LLMs) have excelled in various natural language processing tasks, but challenges in interpretability and trustworthiness persist, limiting their use in high-stakes fields. Causal discovery offers a promising approach…

Artificial Intelligence · Computer Science 2024-06-10 Wei Zhou , Hong Huang , Guowen Zhang , Ruize Shi , Kehan Yin , Yuanyuan Lin , Bang Liu

Large language model (LLM) agents-especially smaller, open-source models-often produce causally invalid or incoherent actions in collaborative tasks due to their reliance on surface-level correlations rather than grounded causal reasoning.…

Artificial Intelligence · Computer Science 2025-08-20 Minh Hoang Nguyen , Van Dai Do , Dung Nguyen , Thin Nguyen , Hung Le

The discovery of causal relationships between random variables is an important yet challenging problem that has applications across many scientific domains. Differentiable causal discovery (DCD) methods are effective in uncovering causal…

Machine Learning · Computer Science 2024-10-29 Shiv Kampani , David Hidary , Constantijn van der Poel , Martin Ganahl , Brenda Miao

Revealing hidden causal variables alongside the underlying causal mechanisms is essential to the development of science. Despite the progress in the past decades, existing practice in causal discovery (CD) heavily relies on high-quality…

Machine Learning · Computer Science 2025-10-14 Chenxi Liu , Yongqiang Chen , Tongliang Liu , Mingming Gong , James Cheng , Bo Han , Kun Zhang

Causality is essential for understanding complex systems, such as the economy, the brain, and the climate. Constructing causal graphs often relies on either data-driven or expert-driven approaches, both fraught with challenges. The former…

Artificial Intelligence · Computer Science 2024-06-12 Kai-Hendrik Cohrs , Gherardo Varando , Emiliano Diaz , Vasileios Sitokonstantinou , Gustau Camps-Valls

Causal discovery for both cross-sectional and temporal data has traditionally followed a dataset-specific paradigm, where a new model is fitted for each individual dataset. Such an approach limits the potential of multi-dataset pretraining.…

In practical statistical causal discovery (SCD), embedding domain expert knowledge as constraints into the algorithm is important for reasonable causal models reflecting the broad knowledge of domain experts, despite the challenges in the…

Machine Learning · Computer Science 2025-05-13 Masayuki Takayama , Tadahisa Okuda , Thong Pham , Tatsuyoshi Ikenoue , Shingo Fukuma , Shohei Shimizu , Akiyoshi Sannai

Large Language Models (LLMs) show promise in biomedicine but lack true causal understanding, relying instead on correlations. This paper envisions causal LLM agents that integrate multimodal data (text, images, genomics, etc.) and perform…

Artificial Intelligence · Computer Science 2025-05-23 Adib Bazgir , Amir Habibdoust Lafmajani , Yuwen Zhang

Ensuring fairness in machine learning requires understanding how sensitive attributes like race or gender causally influence outcomes. Existing causal discovery (CD) methods often struggle to recover fairness-relevant pathways in the…

Machine Learning · Computer Science 2026-01-08 Khadija Zanna , Akane Sano
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