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In many biological processes heterogeneity within cell populations is an important issue. In this work we consider populations where the behavior of every single cell can be described by a system of ordinary differential equations.…

Molecular Networks · Quantitative Biology 2010-02-25 J. Hasenauer , S. Waldherr , M. Doszczak , P. Scheurich , F. Allgower

This article presents a new numerical scheme for the discretization of dissipative particle dynamics with conserved energy. The key idea is to reduce elementary pairwise stochastic dynamics (either fluctuation/dissipation or thermal…

Statistical Mechanics · Physics 2017-04-26 Gabriel Stoltz

In this article we discuss several aspects of the stochastic dynamics of spin models. The paper has two independent parts. Firstly, we explore a few properties of the multi-point correlations and responses of generic systems evolving in…

Statistical Mechanics · Physics 2009-11-10 Guilhem Semerjian , Leticia F. Cugliandolo , Andrea Montanari

Modeling biological processes is a highly demanding task because not all processes are fully understood. Mathematical models allow us to test hypotheses about possible mechanisms of biological processes. The mathematical mechanisms…

Numerical Analysis · Mathematics 2023-12-11 Cordula Reisch , Hannah Burmester

Many collective systems exist in nature far from equilibrium, ranging from cellular sheets up to flocks of birds. These systems reflect a form of active matter, whereby individual material components have internal energy. Under specific…

Soft Condensed Matter · Physics 2023-04-17 Namid R. Stillman , Silke Henkes , Roberto Mayor , Gilles Louppe

Multiscale dynamics are frequently present in real-world processes, such as the atmosphere-ocean and climate science. Because of time scale separation between a small set of slowly evolving variables and much larger set of rapidly changing…

Dynamical Systems · Mathematics 2016-04-08 Rafail V. Abramov

Event-driven systems in fields such as neuroscience, social networks, and finance often exhibit dynamics influenced by continuously evolving external covariates. Motivated by these applications, we introduce a new class of multivariate…

Statistics Theory · Mathematics 2025-12-02 Maya Sadeler Perrin , Anna Bonnet , Charlotte Dion-Blanc , Adeline Samson

Griffiths phases (GPs), generated by the heterogeneities on modular networks, have recently been suggested to provide a mechanism, rid of fine parameter tuning, to explain the critical behavior of complex systems. One conjectured…

Physics and Society · Physics 2018-06-15 Wesley Cota , Géza Ódor , Silvio C. Ferreira

Parametric models abstract part of the specification of dynamical models by integral parameters. They are for example used in computational systems biology, notably with parametric regulatory networks, which specify the global architecture…

Logic in Computer Science · Computer Science 2018-11-30 Stefan Haar , Juraj Kolčák , Loïc Paulevé

Simulations of complex physical systems are typically realized by discretizing partial differential equations (PDEs) on unstructured meshes. While neural networks have recently been explored for surrogate and reduced order modeling of PDE…

Machine Learning · Computer Science 2021-10-27 Jiayang Xu , Aniruddhe Pradhan , Karthik Duraisamy

Biophysical models describing complex, cellular phenomena typically include systems of nonlinear differential equations with many free parameters. While experimental measurements can fix some parameters, those describing internal cellular…

Computational Physics · Physics 2025-07-08 Joseph M. Marcinik , Martín A. Toderi , Dolores Bozovic

This paper develops a comprehensive mathematical framework for energy-based modeling of physical systems, with particular emphasis on preserving fundamental structural properties throughout the modeling and discretization process. The…

Numerical Analysis · Mathematics 2025-12-11 M. H. M Rashid

We present a new parameterization of quintessence potentials for dark energy based directly upon the dynamical properties of the equations of motion. Such parameterization arises naturally once the equations of motion are written as a…

General Relativity and Quantum Cosmology · Physics 2018-11-07 Nandan Roy , Alma X. Gonzalez-Morales , L. Arturo Urena-Lopez

Many living and complex systems exhibit second order emergent dynamics. Limited experimental access to the configurational degrees of freedom results in data that appears to be generated by a non-Markovian process. This poses a challenge in…

Quantitative Methods · Quantitative Biology 2020-07-29 Federica Ferretti , Victor Chardès , Thierry Mora , Aleksandra M. Walczak , Irene Giardina

Hypoelliptic diffusion processes can be used to model a variety of phenomena in applications ranging from molecular dynamics to audio signal analysis. We study parameter estimation for such processes in situations where we observe some…

Methodology · Statistics 2007-10-30 Y. Pokern , A. M. Stuart , P. Wiberg

Molecular simulations as well as single molecule experiments have been widely analyzed in terms order parameters, the latter representing candidate probes for the relevant degrees of freedom. Notwithstanding this approach is very intuitive,…

Chemical Physics · Physics 2015-06-11 Ganna Berezovska , Diego Prada-Gracia , Stefano Mostarda , Francesco Rao

Many systems in biology, physics and engineering can be described by systems of ordinary differential equation containing many parameters. When studying the dynamic behavior of these large, nonlinear systems, it is useful to identify and…

Molecular Networks · Quantitative Biology 2016-04-13 Heather A. Harrington , Dhagash Mehta , Helen M. Byrne , Jonathan D. Hauenstein

We present a simple model for describing the dynamics of the interaction between a homogeneous population or society, and the natural resources and reserves that the society needs for its survival. The model is formulated in terms of…

Physics and Society · Physics 2020-04-22 Basil Grammaticos , Ralph Willox , Junkichi Satsuma

Dynamic heterogeneity has often been modeled by assuming that a single-particle observable, fluctuating at a molecular scale, is influenced by its coupling to environmental variables fluctuating on a second, perhaps slower, time scale.…

Condensed Matter · Physics 2009-11-07 Gregor Diezemann , Gerald Hinze , Hans Sillescu

Stochastic processes offer a flexible mathematical formalism to model and reason about systems. Most analysis tools, however, start from the premises that models are fully specified, so that any parameters controlling the system's dynamics…

Systems and Control · Computer Science 2017-01-11 Luca Bortolussi , Guido Sanguinetti
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