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Direct Preference Optimization (DPO) has emerged as a de-facto approach for aligning language models with human preferences. Recent work has shown DPO's effectiveness relies on training data quality. In particular, clear quality differences…

Machine Learning · Computer Science 2025-01-28 Nirav Diwan , Tolga Ergen , Dongsub Shim , Honglak Lee

Large Vision-Language Models (LVLMs) hold significant promise for medical applications, yet their deployment is often constrained by insufficient alignment and reliability. While Direct Preference Optimization (DPO) has emerged as a potent…

Computer Vision and Pattern Recognition · Computer Science 2026-01-27 Dain Kim , Jiwoo Lee , Jaehoon Yun , Yong Hoe Koo , Qingyu Chen , Hyunjae Kim , Jaewoo Kang

As large language models (LLMs) see greater use in academic and commercial settings, there is increasing interest in methods that allow language models to generate texts aligned with human preferences. In this paper, we present an initial…

Machine Learning · Computer Science 2024-06-07 Victoria Lin , Eli Ben-Michael , Louis-Philippe Morency

Large language models (LLMs) have shown great potential in natural language processing tasks, but their application to machine translation (MT) remains challenging due to pretraining on English-centric data and the complexity of…

Computation and Language · Computer Science 2025-01-24 Guofeng Cui , Pichao Wang , Yang Liu , Zemian Ke , Zhu Liu , Vimal Bhat

Direct Preference Optimization (DPO) has been successfully used to align large language models (LLMs) according to human preferences, and more recently it has also been applied to improving the quality of text-to-image diffusion models.…

Computer Vision and Pattern Recognition · Computer Science 2025-10-07 Shivanshu Shekhar , Shreyas Singh , Tong Zhang

Radiography Report Generation (RRG) has gained significant attention in medical image analysis as a promising tool for alleviating the growing workload of radiologists. However, despite numerous advancements, existing methods have yet to…

Computer Vision and Pattern Recognition · Computer Science 2025-09-29 Valentin Samokhin , Boris Shirokikh , Mikhail Goncharov , Dmitriy Umerenkov , Maksim Bobrin , Ivan Oseledets , Dmitry Dylov , Mikhail Belyaev

Direct preference optimization (DPO) is a form of reinforcement learning from human feedback (RLHF) where the policy is learned directly from preferential feedback. Although many models of human preferences exist, the critical task of…

Machine Learning · Computer Science 2025-03-04 Branislav Kveton , Xintong Li , Julian McAuley , Ryan Rossi , Jingbo Shang , Junda Wu , Tong Yu

With the rapid advancement of large language models (LLMs), aligning policy models with human preferences has become increasingly critical. Direct Preference Optimization (DPO) has emerged as a promising approach for alignment, acting as an…

Artificial Intelligence · Computer Science 2025-07-15 Wenyi Xiao , Zechuan Wang , Leilei Gan , Shuai Zhao , Zongrui Li , Ruirui Lei , Wanggui He , Luu Anh Tuan , Long Chen , Hao Jiang , Zhou Zhao , Fei Wu

Diffusion models have achieved promising results for Structure-Based Drug Design (SBDD). Nevertheless, high-quality protein subpocket and ligand data are relatively scarce, which hinders the models' generation capabilities. Recently, Direct…

Biomolecules · Quantitative Biology 2026-02-11 Xiwei Cheng , Xiangxin Zhou , Yuwei Yang , Yu Bao , Quanquan Gu

As large language models (LLMs) become more capable, fine-tuning techniques for aligning with human intent are increasingly important. A key consideration for aligning these models is how to most effectively use human resources, or model…

Machine Learning · Computer Science 2024-07-01 William Muldrew , Peter Hayes , Mingtian Zhang , David Barber

Large language models (LLMs) are fine-tuned using human comparison data with Reinforcement Learning from Human Feedback (RLHF) methods to make them better aligned with users' preferences. In contrast to LLMs, human preference learning has…

Computer Vision and Pattern Recognition · Computer Science 2023-11-23 Bram Wallace , Meihua Dang , Rafael Rafailov , Linqi Zhou , Aaron Lou , Senthil Purushwalkam , Stefano Ermon , Caiming Xiong , Shafiq Joty , Nikhil Naik

Preference learning extends the performance of Code LLMs beyond traditional supervised fine-tuning by leveraging relative quality comparisons. In existing approaches, a set of n candidate solutions is evaluated based on test case success…

Computation and Language · Computer Science 2025-10-10 Jie Wu , Haoling Li , Xin Zhang , Xiao Liu , Yangyu Huang , Jianwen Luo , Yizhen Zhang , Zuchao Li , Ruihang Chu , Yujiu Yang , Scarlett Li

Direct Preference Optimization (DPO) simplifies reinforcement learning from human feedback (RLHF) for large language models (LLMs) by directly optimizing human preferences without an explicit reward model. We find that during DPO training,…

Computation and Language · Computer Science 2026-01-01 Junshu Pan , Wei Shen , Shulin Huang , Qiji Zhou , Yue Zhang

How can Large Language Models (LLMs) be aligned with human intentions and values? A typical solution is to gather human preference on model outputs and finetune the LLMs accordingly while ensuring that updates do not deviate too far from a…

Computation and Language · Computer Science 2024-05-28 Hung Le , Quan Tran , Dung Nguyen , Kien Do , Saloni Mittal , Kelechi Ogueji , Svetha Venkatesh

Direct Preference Optimization is an offline post-SFT method for aligning language models from preference pairs, with strong results in instruction following and summarization. However, DPO's sequence-level implicit reward can be brittle…

Computation and Language · Computer Science 2026-03-03 Samah Fodeh , Linhai Ma , Ganesh Puthiaraju , Srivani Talakokkul , Afshan Khan , Ashley Hagaman , Sarah R. Lowe , Aimee Kendall Roundtree

We introduce ConfPO, a method for preference learning in Large Language Models (LLMs) that identifies and optimizes preference-critical tokens based solely on the training policy's confidence, without requiring any auxiliary models or…

Computation and Language · Computer Science 2025-06-13 Hee Suk Yoon , Eunseop Yoon , Mark Hasegawa-Johnson , Sungwoong Kim , Chang D. Yoo

Direct Preference Optimization (DPO) is an effective framework for aligning large language models with human preferences, but it struggles with complex reasoning tasks. DPO optimizes for the likelihood of generating preferred over…

Artificial Intelligence · Computer Science 2026-04-23 Darsh Kachroo , Adriana Caraeni , Arjun Prasaath Anbazhagan , Brennan Lagasse , Kevin Zhu

Reinforcement learning from human feedback (RLHF) plays a crucial role in aligning language models with human preferences. While the significance of dataset quality is generally recognized, explicit investigations into its impact within the…

Machine Learning · Computer Science 2024-12-04 Tetsuro Morimura , Mitsuki Sakamoto , Yuu Jinnai , Kenshi Abe , Kaito Ariu

The class of direct preference optimization (DPO) algorithms has emerged as a promising approach for solving the alignment problem in foundation models. These algorithms work with very limited feedback in the form of pairwise preferences…

Machine Learning · Computer Science 2026-02-03 Luca Viano , Ruida Zhou , Yifan Sun , Mahdi Namazifar , Volkan Cevher , Shoham Sabach , Mohammad Ghavamzadeh

While large-scale unsupervised language models (LMs) learn broad world knowledge and some reasoning skills, achieving precise control of their behavior is difficult due to the completely unsupervised nature of their training. Existing…

Machine Learning · Computer Science 2024-07-31 Rafael Rafailov , Archit Sharma , Eric Mitchell , Stefano Ermon , Christopher D. Manning , Chelsea Finn
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