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Recent advances in diffusion models have improved Real-World Image Super-Resolution (Real-ISR), but existing methods lack human feedback integration, risking misalignment with human preference and may leading to artifacts, hallucinations…

Direct Preference Optimization (DPO) is an effective framework for aligning large language models with human preferences, but it struggles with complex reasoning tasks. DPO optimizes for the likelihood of generating preferred over…

Direct Preference Optimization (DPO) has become a standard framework for safety alignment, but its reliance on pairwise preference updates makes training sensitive to imperfect supervision. Existing robust DPO methods often address this…

Extractive question answering over clinical text is a crucial need to help deal with the deluge of clinical text generated in hospitals. While encoder models (e.g., BERT) have been popular for this reading comprehension task, recently…

Human image generation is a key focus in image synthesis due to its broad applications, but even slight inaccuracies in anatomy, pose, or details can compromise realism. To address these challenges, we explore Direct Preference Optimization…

Recent advancements in human preference optimization, initially developed for Language Models (LMs), have shown promise for text-to-image Diffusion Models, enhancing prompt alignment, visual appeal, and user preference. Unlike LMs,…

In the field of large language models (LLMs), aligning models with the diverse preferences of users is a critical challenge. Direct Preference Optimization (DPO) has played a key role in this area. It works by using pairs of preferences…

In large language model (LLM)-based recommendation systems, direct preference optimization (DPO) effectively aligns recommendations with user preferences, requiring multi-negative objective functions to leverage abundant implicit-feedback…

Recent alignment methods based on Direct Preference Optimization (DPO) reformulate preference learning as supervised optimization over pairwise comparisons, offering improved efficiency and stability over reinforcement learning from human…

Recommender systems aim to predict personalized rankings based on user preference data. With the rise of Language Models (LMs), LM-based recommenders have been widely explored due to their extensive world knowledge and powerful reasoning…

Structure-based drug design (SBDD) aims to efficiently discover high-affinity ligands within vast chemical spaces. However, current generative models struggle with objective misalignment and rigid sampling budgets. We present MolFORM, a…

Aligning text-to-image (T2I) diffusion models with Direct Preference Optimization (DPO) has shown notable improvements in generation quality. However, applying DPO to T2I faces two challenges: the sensitivity of DPO to preference pairs and…

This paper introduces V2A-DPO, a novel Direct Preference Optimization (DPO) framework tailored for flow-based video-to-audio generation (V2A) models, incorporating key adaptations to effectively align generated audio with human preferences.…

Recent advancements in Direct Preference Optimization (DPO) have significantly enhanced the alignment of Large Language Models (LLMs) with human preferences, owing to its simplicity and effectiveness. However, existing methods typically…

Large Protein Language Models have shown strong potential for generative protein design, yet they frequently produce structural hallucinations, generating sequences with high linguistic likelihood that fold into thermodynamically unstable…

Accurate exploration of protein conformational ensembles is essential for uncovering function but remains hard because molecular-dynamics (MD) simulations suffer from high computational costs and energy-barrier trapping. This paper presents…

Diffusion models have demonstrated remarkable success in various visual generation tasks, including image, video, and 3D content generation. Preference optimization (PO) is a prominent and growing area of research that aims to align these…

Direct Preference Optimization is an offline post-SFT method for aligning language models from preference pairs, with strong results in instruction following and summarization. However, DPO's sequence-level implicit reward can be brittle…

Preferences within a group of people are not uniform but follow a distribution. While existing alignment methods like Direct Preference Optimization (DPO) attempt to steer models to reflect human preferences, they struggle to capture the…

With the rapid advancement of large language models (LLMs), aligning policy models with human preferences has become increasingly critical. Direct Preference Optimization (DPO) has emerged as a promising approach for alignment, acting as an…