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Spatial Transcriptomics (ST) offers spatially resolved gene expression but remains costly. Predicting expression directly from widely available Hematoxylin and Eosin (H&E) stained images presents a cost-effective alternative. However, most…

Computer Vision and Pattern Recognition · Computer Science 2025-10-07 Jiarui Ouyang , Yihui Wang , Yihang Gao , Yingxue Xu , Shu Yang , Hao Chen

The integration of spatial multi-omics data from single tissues is crucial for advancing biological research. However, a significant data imbalance impedes progress: while spatial transcriptomics data is relatively abundant, spatial…

Artificial Intelligence · Computer Science 2026-02-06 Zhaorui Jiang , Yingfang Yuan , Lei Hu , Wei Pang

Pansharpening is a significant image fusion technique that merges the spatial content and spectral characteristics of remote sensing images to generate high-resolution multispectral images. Recently, denoising diffusion probabilistic models…

Computer Vision and Pattern Recognition · Computer Science 2024-04-18 Yu Zhong , Xiao Wu , Liang-Jian Deng , Zihan Cao

Single-cell spatial transcriptomics (ST) offers a unique approach to measuring gene expression profiles and spatial cell locations simultaneously. However, most existing ST methods assume that cells in closer spatial proximity exhibit more…

Genomics · Quantitative Biology 2025-06-10 Xiongtao Xiao , Xiaofeng Chen , Feiyan Jiang , Songming Zhang , Wenming Cao , Cheng Tan , Zhangyang Gao , Zhongshan Li

Generative models, such as GANs and diffusion models, have been used to augment training sets and boost performances in different tasks. We focus on generative models for cell detection instead, i.e., locating and classifying cells in given…

Computer Vision and Pattern Recognition · Computer Science 2024-09-06 Chen Li , Xiaoling Hu , Shahira Abousamra , Meilong Xu , Chao Chen

Deep generative models have advanced text-to-online handwriting generation (TOHG), which aims to synthesize realistic pen trajectories conditioned on textual input and style references. However, most existing methods still primarily focus…

Computer Vision and Pattern Recognition · Computer Science 2026-03-03 Wei Pan , Huiguo He , Hiuyi Cheng , Yilin Shi , Lianwen Jin

Understanding and predicting the progression of neurodegenerative diseases remains a major challenge in medical AI, with significant implications for early diagnosis, disease monitoring, and treatment planning. However, most available…

Computer Vision and Pattern Recognition · Computer Science 2026-04-27 Nivetha Jayakumar , Swakshar Deb , Bahram Jafrasteh , Qingyu Zhao , Miaomiao Zhang

As a powerful tool for characterizing cellular subpopulations and cellular heterogeneity, single cell RNA sequencing (scRNA-seq) technology offers advantages of high throughput and multidimensional analysis. However, the process of data…

Machine Learning · Computer Science 2024-11-19 Zhuorui Cui , Shengze Dong , Ding Liu

Diffusion models have recently received increasing research attention for their remarkable transfer abilities in semantic segmentation tasks. However, generating fine-grained segmentation masks with diffusion models often requires…

Computer Vision and Pattern Recognition · Computer Science 2024-01-23 Koichi Namekata , Amirmojtaba Sabour , Sanja Fidler , Seung Wook Kim

Due to limitations such as geographic, physical, or economic factors, collected seismic data often have missing traces. Traditional seismic data reconstruction methods face the challenge of selecting numerous empirical parameters and…

Geophysics · Physics 2026-01-09 Shuang Wang , Fei Deng , Peifan Jiang , Zezheng Ni , Bin Wang

This work presents RNAdiffusion, a latent diffusion model for generating and optimizing discrete RNA sequences of variable lengths. RNA is a key intermediary between DNA and protein, exhibiting high sequence diversity and complex…

Machine Learning · Computer Science 2024-10-03 Kaixuan Huang , Yukang Yang , Kaidi Fu , Yanyi Chu , Le Cong , Mengdi Wang

The proposed BSDE-based diffusion model represents a novel approach to diffusion modeling, which extends the application of stochastic differential equations (SDEs) in machine learning. Unlike traditional SDE-based diffusion models, our…

Machine Learning · Computer Science 2023-04-27 Zihao Wang

Learning from a large corpus of data, pre-trained models have achieved impressive progress nowadays. As popular generative pre-training, diffusion models capture both low-level visual knowledge and high-level semantic relations. In this…

Computer Vision and Pattern Recognition · Computer Science 2023-03-20 Chaofan Ma , Yuhuan Yang , Chen Ju , Fei Zhang , Jinxiang Liu , Yu Wang , Ya Zhang , Yanfeng Wang

Deep learning models in computational pathology often fail to generalize across cohorts and institutions due to domain shift. Existing approaches either fail to leverage unlabeled data from the target domain or rely on image-to-image…

Computer Vision and Pattern Recognition · Computer Science 2026-01-27 Tengyue Zhang , Ruiwen Ding , Luoting Zhuang , Yuxiao Wu , Erika F. Rodriguez , William Hsu

Spatial transcriptomics enables gene expression profiling with spatial context, offering unprecedented insights into the tissue microenvironment. However, most computational models treat genes as isolated numerical features, ignoring the…

Machine Learning · Computer Science 2025-11-17 Jiangkai Long , Yanran Zhu , Chang Tang , Kun Sun , Yuanyuan Liu , Xuesong Yan

Diffusion models have achieved state-of-the-art results on many modalities including images, speech, and video. However, existing models are not tailored to support remote sensing data, which is widely used in important applications…

Computer Vision and Pattern Recognition · Computer Science 2024-05-28 Samar Khanna , Patrick Liu , Linqi Zhou , Chenlin Meng , Robin Rombach , Marshall Burke , David Lobell , Stefano Ermon

Spatio-temporal modeling is foundational for smart city applications, yet it is often hindered by data scarcity in many cities and regions. To bridge this gap, we propose a novel generative pre-training framework, GPD, for spatio-temporal…

Machine Learning · Computer Science 2024-03-26 Yuan Yuan , Chenyang Shao , Jingtao Ding , Depeng Jin , Yong Li

We present Scalable Interpolant Transformers (SiT), a family of generative models built on the backbone of Diffusion Transformers (DiT). The interpolant framework, which allows for connecting two distributions in a more flexible way than…

Computer Vision and Pattern Recognition · Computer Science 2024-09-24 Nanye Ma , Mark Goldstein , Michael S. Albergo , Nicholas M. Boffi , Eric Vanden-Eijnden , Saining Xie

Style transfer aims to fuse the artistic representation of a style image with the structural information of a content image. Existing methods train specific networks or utilize pre-trained models to learn content and style features.…

Computer Vision and Pattern Recognition · Computer Science 2024-10-22 Ying Hu , Chenyi Zhuang , Pan Gao

Scene Text Image Super-Resolution (STISR) aims to enhance the resolution and legibility of text within low-resolution (LR) images, consequently elevating recognition accuracy in Scene Text Recognition (STR). Previous methods predominantly…

Computer Vision and Pattern Recognition · Computer Science 2023-11-23 Yuxuan Zhou , Liangcai Gao , Zhi Tang , Baole Wei
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