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The versatility of large language models (LLMs) has been explored across various sectors, but their application in healthcare poses challenges, particularly in the domain of pharmaceutical contraindications where accurate and reliable…

Artificial Intelligence · Computer Science 2025-08-11 Byeonghun Bang , Jongsuk Yoon , Dong-Jin Chang , Seho Park , Yong Oh Lee

Large Language Models (LLMs) have demonstrated substantial progress in biomedical and clinical applications, motivating rigorous evaluation of their ability to answer nuanced, evidence-based questions. We curate a multi-source benchmark…

Computation and Language · Computer Science 2025-09-16 Can Wang , Yiqun Chen

Large language models (LLMs) have shown impressive capabilities across a wide range of language tasks. However, their reasoning process is primarily guided by statistical patterns in training data, which limits their ability to handle novel…

Artificial Intelligence · Computer Science 2025-08-21 Hong Su

Large language models (LLMs) holds significant promise in achieving general medication recommendation systems owing to their comprehensive interpretation of clinical notes and flexibility to medication encoding. We evaluated both…

Information Retrieval · Computer Science 2025-08-05 Zihao Zhao , Chenxiao Fan , Junlong Liu , Zheng Wang , Xiangnan He , Chongming Gao , Juan Li , Fuli Feng

Large Language Models (LLMs), known for their versatility in textual data, are increasingly being explored for their potential to enhance medical image segmentation, a crucial task for accurate diagnostic imaging. This study explores…

Image and Video Processing · Electrical Eng. & Systems 2025-08-20 Gurucharan Marthi Krishna Kumar , Aman Chadha , Janine Mendola , Amir Shmuel

This paper explores the potential of using Large Language Models (LLMs) to automate the evaluation of responses in medical Question and Answer (Q\&A) systems, a crucial form of Natural Language Processing. Traditionally, human evaluation…

Computation and Language · Computer Science 2024-09-04 Jack Krolik , Herprit Mahal , Feroz Ahmad , Gaurav Trivedi , Bahador Saket

Large language models (LLMs) have made significant progress in various domains, including healthcare. However, the specialized nature of clinical language understanding tasks presents unique challenges and limitations that warrant further…

Computation and Language · Computer Science 2023-08-01 Yuqing Wang , Yun Zhao , Linda Petzold

This study presents a comprehensive analysis and comparison of two predominant fine-tuning methodologies - full-parameter fine-tuning and parameter-efficient tuning - within the context of medical Large Language Models (LLMs). We developed…

Background: Large language models (LLMs) show promise in medicine, but their deployment in hospitals is limited by restricted access to electronic health record (EHR) systems. The Model Context Protocol (MCP) enables integration between…

Artificial Intelligence · Computer Science 2025-09-22 Kanato Masayoshi , Masahiro Hashimoto , Ryoichi Yokoyama , Naoki Toda , Yoshifumi Uwamino , Shogo Fukuda , Ho Namkoong , Masahiro Jinzaki

The high incidence and mortality rates associated with respiratory diseases underscores the importance of early screening. Machine learning models can automate clinical consultations and auscultation, offering vital support in this area.…

Machine Learning · Computer Science 2024-10-10 Yuwei Zhang , Tong Xia , Aaqib Saeed , Cecilia Mascolo

Identifying disease phenotypes from electronic health records (EHRs) is critical for numerous secondary uses. Manually encoding physician knowledge into rules is particularly challenging for rare diseases due to inadequate EHR coding,…

Information retrieval systems are crucial for enabling effective access to large document collections. Recent approaches have leveraged Large Language Models (LLMs) to enhance retrieval performance through query augmentation, but often rely…

Information Retrieval · Computer Science 2025-04-15 Pengcheng Jiang , Jiacheng Lin , Lang Cao , Runchu Tian , SeongKu Kang , Zifeng Wang , Jimeng Sun , Jiawei Han

Large Language Models (LLMs) have recently demonstrated remarkable performance in various Natural Language Processing (NLP) applications, such as sentiment analysis, content generation, and personalized recommendations. Despite their…

Computation and Language · Computer Science 2024-12-10 Mahaman Sanoussi Yahaya Alassan , Jessica López Espejel , Merieme Bouhandi , Walid Dahhane , El Hassane Ettifouri

Medical retrieval-augmented generation (RAG) systems typically operate on text chunks extracted from biomedical literature, discarding the rich visual content (tables, figures, structured layouts) of original document pages. We propose…

Artificial Intelligence · Computer Science 2026-05-01 Xupeng Chen , Binbin Shi , Chenqian Le , Jiaqi Zhang , Kewen Wang , Ran Gong , Jinhan Zhang , Chihang Wang

Frontier large language models (LLMs), such as GPT-5, Claude 4.5, Gemini 3, Llama 4, and DeepSeek-R1, represent a transformative class of AI tools capable of revolutionizing various aspects of healthcare by generating human-like responses…

In the face of rapidly expanding online medical literature, automated systems for aggregating and summarizing information are becoming increasingly crucial for healthcare professionals and patients. Large Language Models (LLMs), with their…

Computation and Language · Computer Science 2024-03-07 Niraj Yagnik , Jay Jhaveri , Vivek Sharma , Gabriel Pila

Incorporating large language models (LLMs) in medical question answering demands more than high average accuracy: a model that returns substantively different answers each time it is queried is not a reliable medical tool. Online health…

Information Retrieval · Computer Science 2026-04-14 Avi-ad Avraam Buskila

Large language models (LLMs) have shown promise in medical question answering but often struggle with hallucinations and shallow reasoning, particularly in tasks requiring nuanced clinical understanding. Retrieval-augmented generation (RAG)…

Computation and Language · Computer Science 2025-08-25 Ziyu Wang , Elahe Khatibi , Amir M. Rahmani

Text ranking is a critical task in information retrieval. Recent advances in pre-trained language models (PLMs), especially large language models (LLMs), present new opportunities for applying them to text ranking. While supervised…

Information Retrieval · Computer Science 2024-06-04 Longhui Zhang , Yanzhao Zhang , Dingkun Long , Pengjun Xie , Meishan Zhang , Min Zhang

The remarkable ability of Large Language Models (LLMs) to understand and follow instructions has sometimes been limited by their in-context learning (ICL) performance in low-resource languages. To address this, we introduce a novel approach…

Computation and Language · Computer Science 2023-12-06 Xiaoqian Li , Ercong Nie , Sheng Liang
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