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With large training datasets and massive amounts of computing sources, large language models (LLMs) achieve remarkable performance in comprehensive and generative ability. Based on those powerful LLMs, the model fine-tuned with…

Computation and Language · Computer Science 2024-01-12 Xuyang Zhao , Qibin Zhao , Toshihisa Tanaka

Large language models (LLMs) are being explored for diagnostic decision support, yet their ability to estimate pre-test probabilities, vital for clinical decision-making, remains limited. This study evaluates two LLMs, Mistral-7B and…

The capabilities of large language models (LLMs) have expanded beyond natural language processing to scientific prediction tasks, including molecular property prediction. However, their effectiveness in in-context learning remains…

Injecting external domain-specific knowledge (e.g., UMLS) into pretrained language models (LMs) advances their capability to handle specialised in-domain tasks such as biomedical entity linking (BEL). However, such abundant expert knowledge…

Computation and Language · Computer Science 2021-06-01 Fangyu Liu , Ivan Vulić , Anna Korhonen , Nigel Collier

Recent studies show that deep learning models achieve good performance on medical imaging tasks such as diagnosis prediction. Among the models, multimodality has been an emerging trend, integrating different forms of data such as chest…

Machine Learning · Computer Science 2022-02-10 Haodi Zhang , Chenyu Xu , Peirou Liang , Ke Duan , Hao Ren , Weibin Cheng , Kaishun Wu

In many applications of LLMs, natural language responses often have an underlying structure such as representing discrete labels, numerical values, or graphs. Yet, existing decoding and uncertainty estimation methods operate only in…

Machine Learning · Computer Science 2026-05-25 Tim Tomov , Dominik Fuchsgruber , Stephan Günnemann

The non-humanlike behaviour of contemporary pre-trained language models (PLMs) is a leading cause undermining their trustworthiness. A striking phenomenon of such faulty behaviours is the generation of inconsistent predictions, which…

Computation and Language · Computer Science 2023-10-25 Myeongjun Erik Jang , Thomas Lukasiewicz

In the face of rapidly expanding online medical literature, automated systems for aggregating and summarizing information are becoming increasingly crucial for healthcare professionals and patients. Large Language Models (LLMs), with their…

Computation and Language · Computer Science 2024-03-07 Niraj Yagnik , Jay Jhaveri , Vivek Sharma , Gabriel Pila

Despite the growing demand for eliciting uncertainty from large language models (LLMs), empirical evidence suggests that LLM behavior is not always adequately captured by the elicitation techniques developed under the classical…

Artificial Intelligence · Computer Science 2026-03-12 Anita Yang , Krikamol Muandet , Michele Caprio , Siu Lun Chau , Masaki Adachi

Large language model (LLM) agents are increasingly deployed in structured biomedical data environments, yet they often produce fluent but overconfident outputs when reasoning over complex multi-table data. We introduce an uncertainty-aware…

Pre-trained Large Language Models (LLMs) often struggle on out-of-domain datasets like healthcare focused text. We explore specialized pre-training to adapt smaller LLMs to different healthcare datasets. Three methods are assessed:…

Computation and Language · Computer Science 2024-04-01 Niall Taylor , Dan Schofield , Andrey Kormilitzin , Dan W Joyce , Alejo Nevado-Holgado

The increasing use of tools and solutions based on Large Language Models (LLMs) for various tasks in the medical domain has become a prominent trend. Their use in this highly critical and sensitive domain has thus raised important questions…

Computation and Language · Computer Science 2024-01-09 Jean-Baptiste Excoffier , Tom Roehr , Alexei Figueroa , Jens-Michalis Papaioannou , Keno Bressem , Matthieu Ortala

The usual figure of merit characterizing the performance of neural networks applied to problems in the quantum domain is their accuracy, being the probability of a correct answer on a previously unseen input. Here we append this parameter…

Quantum Physics · Physics 2022-12-29 Jan Wasilewski , Tomasz Paterek , Karol Horodecki

One of the major aspects contributing to the striking performance of large language models (LLMs) is the vast amount of factual knowledge accumulated during pre-training. Yet, many LLMs suffer from self-inconsistency, which raises doubts…

Computation and Language · Computer Science 2024-10-07 Anastasiia Sedova , Robert Litschko , Diego Frassinelli , Benjamin Roth , Barbara Plank

As Large Language Models (LLMs) are increasingly integrated in diverse applications, obtaining reliable measures of their predictive uncertainty has become critically important. A precise distinction between aleatoric uncertainty, arising…

Recently natural language processing (NLP) tools have been developed to identify and extract salient risk indicators in electronic health records (EHRs). Sentiment analysis, although widely used in non-medical areas for improving decision…

Computation and Language · Computer Science 2019-04-09 Eben Holderness , Philip Cawkwell , Kirsten Bolton , James Pustejovsky , Mei-Hua Hall

Large language models (LLMs) have demonstrated dominating performance in many NLP tasks, especially on generative tasks. However, they often fall short in some information extraction tasks, particularly those requiring domain-specific…

Computation and Language · Computer Science 2023-09-22 Junyi Bian , Jiaxuan Zheng , Yuyi Zhang , Shanfeng Zhu

The impact of machine learning models on healthcare will depend on the degree of trust that healthcare professionals place in the predictions made by these models. In this paper, we present a method to provide people with clinical expertise…

Machine Learning · Computer Science 2021-03-05 Aniruddh Raghu , John Guttag , Katherine Young , Eugene Pomerantsev , Adrian V. Dalca , Collin M. Stultz

The development of Large Language Models (LLMs) in various languages has been advancing, but the combination of non-English languages with domain-specific contexts remains underexplored. This paper presents our findings from training and…

Computation and Language · Computer Science 2024-11-07 Kosuke Takahashi , Takahiro Omi , Kosuke Arima , Tatsuya Ishigaki

Uncertainty estimation is crucial for evaluating Large Language Models (LLMs), particularly in high-stakes domains where incorrect answers result in significant consequences. Numerous approaches consider this problem, while focusing on a…

Computation and Language · Computer Science 2025-03-04 Petr Sychev , Andrey Goncharov , Daniil Vyazhev , Edvard Khalafyan , Alexey Zaytsev