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This study investigates uncertainty quantification in large language models (LLMs) for medical applications, emphasizing both technical innovations and philosophical implications. As LLMs become integral to clinical decision-making,…

Artificial Intelligence · Computer Science 2025-04-08 Zahra Atf , Seyed Amir Ahmad Safavi-Naini , Peter R. Lewis , Aref Mahjoubfar , Nariman Naderi , Thomas R. Savage , Ali Soroush

Pre-trained language models (PLMs) have been the de facto paradigm for most natural language processing (NLP) tasks. This also benefits biomedical domain: researchers from informatics, medicine, and computer science (CS) communities propose…

Computation and Language · Computer Science 2023-07-18 Benyou Wang , Qianqian Xie , Jiahuan Pei , Zhihong Chen , Prayag Tiwari , Zhao Li , Jie fu

We study the feasibility of identifying epistemic uncertainty (reflecting a lack of knowledge), as opposed to aleatoric uncertainty (reflecting entropy in the underlying distribution), in the outputs of large language models (LLMs) over…

Machine Learning · Computer Science 2024-02-28 Gustaf Ahdritz , Tian Qin , Nikhil Vyas , Boaz Barak , Benjamin L. Edelman

Incorporating domain knowledge into the modeling process is an effective way to improve learning accuracy. However, as it is provided by humans, domain knowledge can only be specified with some degree of uncertainty. We propose to…

Machine Learning · Computer Science 2012-05-14 Yi Mao , Guy Lebanon

Reliable uncertainty quantification is a first step towards building explainable, transparent, and accountable artificial intelligent systems. Recent progress in Bayesian deep learning has made such quantification realizable. In this paper,…

Computation and Language · Computer Science 2018-11-20 Yijun Xiao , William Yang Wang

Cutting edge techniques developed in the general NLP domain are often subsequently applied to the high-value, data-rich biomedical domain. The past few years have seen generative language models (LMs), instruction finetuning, and few-shot…

Computation and Language · Computer Science 2025-07-28 Aviv Brokman , Ramakanth Kavuluru

Large Language Models (LLMs) have been widely employed in programming language analysis to enhance human productivity. Yet, their reliability can be compromised by various code distribution shifts, leading to inconsistent outputs. While…

Software Engineering · Computer Science 2024-02-12 Yufei Li , Simin Chen , Yanghong Guo , Wei Yang , Yue Dong , Cong Liu

Deep Learning sets the state-of-the-art in many challenging tasks showing outstanding performance in a broad range of applications. Despite its success, it still lacks robustness hindering its adoption in medical applications. Modeling…

Computer Vision and Pattern Recognition · Computer Science 2019-09-19 Agnieszka Tomczack , Nassir Navab , Shadi Albarqouni

Pre-trained language models (PLMs) have gained increasing popularity due to their compelling prediction performance in diverse natural language processing (NLP) tasks. When formulating a PLM-based prediction pipeline for NLP tasks, it is…

Computation and Language · Computer Science 2022-10-17 Yuxin Xiao , Paul Pu Liang , Umang Bhatt , Willie Neiswanger , Ruslan Salakhutdinov , Louis-Philippe Morency

Large Language Models (LLMs) are increasingly used in clinical settings, where sensitivity to linguistic uncertainty can influence diagnostic interpretation and decision-making. Yet little is known about where such epistemic cues are…

Computation and Language · Computer Science 2025-12-01 Srivarshinee Sridhar , Raghav Kaushik Ravi , Kripabandhu Ghosh

Pre-trained transformer language models (LMs) have in recent years become the dominant paradigm in applied NLP. These models have achieved state-of-the-art performance on tasks such as information extraction, question answering, sentiment…

Computation and Language · Computer Science 2025-04-14 Aidan Mannion , Thierry Chevalier , Didier Schwab , Lorraine Geouriot

We study whether Large Language Models (LLMs) inherently capture domain-specific nuances in natural language. Our experiments probe the domain sensitivity of LLMs by examining their ability to distinguish queries from different domains…

Pretraining large neural language models, such as BERT, has led to impressive gains on many natural language processing (NLP) tasks. However, most pretraining efforts focus on general domain corpora, such as newswire and Web. A prevailing…

Computation and Language · Computer Science 2021-09-20 Yu Gu , Robert Tinn , Hao Cheng , Michael Lucas , Naoto Usuyama , Xiaodong Liu , Tristan Naumann , Jianfeng Gao , Hoifung Poon

Instruction-tuned Large Language Models (LLMs) can perform a wide range of tasks given natural language instructions to do so, but they are sensitive to how such instructions are phrased. This issue is especially concerning in healthcare,…

Neural Linear Models (NLM) are deep Bayesian models that produce predictive uncertainty by learning features from the data and then performing Bayesian linear regression over these features. Despite their popularity, few works have focused…

Machine Learning · Statistics 2021-06-25 Cooper Lorsung

While deep learning techniques have shown promising results in many natural language processing (NLP) tasks, it has not been widely applied to the clinical domain. The lack of large datasets and the pervasive use of domain-specific language…

Computation and Language · Computer Science 2019-06-20 Jiin Nam , Seunghyun Yoon , Kyomin Jung

There are many cases where LLMs are used for specific tasks in a single domain. These usually require less general, but more domain-specific knowledge. Highly capable, general-purpose state-of-the-art language models like GPT-4 or…

Machine Learning · Computer Science 2024-07-30 Tobias Kerner

In recent years, Large Language Models (LLMs) have become fundamental to a broad spectrum of artificial intelligence applications. As the use of LLMs expands, precisely estimating the uncertainty in their predictions has become crucial.…

Artificial Intelligence · Computer Science 2024-10-29 Mohammad Beigi , Sijia Wang , Ying Shen , Zihao Lin , Adithya Kulkarni , Jianfeng He , Feng Chen , Ming Jin , Jin-Hee Cho , Dawei Zhou , Chang-Tien Lu , Lifu Huang

LLMs are increasingly used to make or support high-stakes decisions under uncertainty, where alignment depends not only on factual accuracy but on how models weigh tradeoffs between different outcomes. We present an empirical pipeline for…

Machine Learning · Computer Science 2026-05-12 Khurram Yamin , Jingjing Tang , Eric Horvitz , Bryan Wilder

With the growing amount of text in health data, there have been rapid advances in large pre-trained models that can be applied to a wide variety of biomedical tasks with minimal task-specific modifications. Emphasizing the cost of these…

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